Effect of LSD on Human Pregnancy
JAMA June 1, 1970 DOI: 10.1001/jama.1970.03170220039005 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 121 |
| Population | Human pregnancies following medically administered LSD |
| Dose | low doses |
| Topics | LSD |
| Keywords | Obstetrics Pregnancy Incidence geometry Induced abortions Gynecology Family planning Research methodology Population |
| Citations | 40 |
| Key findings | Spontaneous abortion, premature birth, and birth defect rates were normal after low medical LSD doses, but a higher abortion rate was seen with mixed medical and nonmedical use, and maternal exposure was associated with more abortions than paternal exposure alone. |
Abstract
The frequencies of spontaneous abortions, premature births, and birth defects in 121 human pregnancies following relatively infrequent, low doses of medically administered lysergic acid diethylamide are within the normal ranges. The incidence of spontaneous abortions was above average for a small sample of 27 pregnancies where LSD was ingested under both medical and nonmedical conditions. Spontaneous abortions occurred significantly more frequently when the mother received LSD as opposed to the father only; however, the data do not permit the establishment of a clear causal relationship.
Comparable studies
Other observational and cohort studies on LSD, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution. Human participants | 2016 | Observational cohort | |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Classic psychedelic use is associated with reduced psychological distress and suicidality in the United States adult population. USA adult respondents from the National Survey on Drug Use and Health (2008-2012) | 2015 | Observational cohort | n = 190,000 |
| Psychedelics not linked to mental health problems or suicidal behavior: A population study Randomly selected United States adults | 2015 | Observational cohort | n = 135,095 |
| Whole-Brain Multimodal Neuroimaging Model Using Serotonin Receptor Maps Explains Non-linear Functional Effects of LSD. Healthy human participants | 2018 | Observational study with computational modeling |
Citations in the library
Cited by 7
- LSD and Genetic Damage Science April 30, 1971
- LSD Revisited Archives of General Psychiatry 1971
- Possible Reproductive Detriment in LSD Users JAMA December 11, 1972
- Does LSD induce chromosomal damage and malformations? A review of the literature Teratology August 1, 1972
- Genetic toxicology of lysergic acid diethylamide (LSD-25) Mutation Research/Reviews in Genetic Toxicology 1977
and 2 more in the library
Cites 9
- In Vivo and in Vitro Chromosomal Damage Induced by LSD-25 New England Journal of Medicine November 16, 1967
- Lysergic Acid Diethylamide: Effect on Embryos Science September 15, 1967
- Congenital Malformations Induced by Mescaline, Lysergic Acid Diethylamide, and Bromolysergic Acid in the Hamster Science October 13, 1967
- LSD in Mice: Abnormalities in Meiotic Chromosomes Science June 14, 1968
- Chromosomal Damage in LSD Users JAMA April 15, 1968
and 4 more in the library