Serotonergic psychedelics have shown promise in clinical trials for treating an array of mental health disorders, including depression, anxiety, and post-traumatic stress disorder. Despite these findings, our understanding of how these drugs mechanistically exert their therapeutic effects remains incomplete. While researchers have regularly employed rodent preclinical models to assess such...
Background: Prana Vidya, an ancient yogic science rooted in Vedic, Tantric, and Ayurvedic traditions, emphasizes the cultivation, regulation, and application of Prana—the vital life force considered essential for sustaining physiological, psychological, and spiritual health. It represents a subtle energy-based discipline that harmonizes mind–body interactions through breath control, awareness,...
Abstract Objectives Emotional distress, encompassing stress, anxiety, and depression, is highly prevalent and associated with substantial personal and societal burden. While Mindfulness-Based Cognitive Therapy (MBCT) is an established intervention, its accessibility is often limited by program length, delivery format, and resource demands. Brief, minimally guided, internet-delivered MBCT...
Scientific ReportsSeptember 9, 2025Bogoan Kim, Dayoung Jeong, Yoonseon Choi et al.
The increasing prevalence of depression has highlighted Mindfulness-Based Cognitive Therapy (MBCT) as an effective treatment. However, conventional MBCT has several limitations, including barriers to access, the need for trained professionals, and inconsistent levels of participant engagement. The feasibility of using Virtual Reality (VR) for MBCT has emerged as a promising solution, but...
Remaja merupakan masa peralihan dari masa anak-anak dan masa dewasa. Depresi pada remaja bukan sekadar perasaan sedih atau stres biasa, melainkan kondisi serius yang permanen dan memengaruhi perilaku, emosi, serta cara berpikir mereka. MBCT dapat melatih remaja mengembangkan metacognitive awareness, yaitu kemampuan untuk mengamati pikiran sebagai peristiwa mental yang sementara, bukan sebagai...
AbstractBackgroundResearch has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the...
Abstract Mindfulness-based programmes (MBPs) have proven effective in enhancing mental health outcomes among non-clinical populations, yet they face significant attrition rates. The role of virtual reality (VR) in improving engagement and effectiveness within this context remains uncertain. To explore the potential acceptability and effectiveness of VR-based mindfulness interventions for mental...
Ketamine， a non-competitive N-methyl-D-aspartate （NMDA） receptor antagonist， has gained increasing attention for its rapid antidepressant effects in treatment-resistant depression （TRD） and suicidal ideation. Its mechanisms include NMDA receptor blockade， AMPA receptor activation， and upregulation of BDNF/mTOR signaling. Its enantiomers， esketamine and R-ketamine， as well as its metabolites，...
Psychedelic drugs, known for their profound effects on perception, cognition, and emotion, have long captivated scientific, cultural, and therapeutic interest. Following the discovery of LSD’s psychoactive properties in 1943, research surged into its therapeutic potential and the nature of consciousness. However, the integration of psychedelics into the 1960s counterculture led to moral panic,...
Tropane alkaloids and their derivatives represent a diverse class of small molecules with a broad range of therapeutic applications. Many tropanes regulate synaptic levels of neuromodulators by interacting with monoamine transporters such as dopamine (DAT) and serotonin (SERT) transporters. While DAT inhibition plays an important role in the addictive potential of tropanes such as cocaine,...