October 3, 2026Juliana Estévez, David Lameiras, Giancarlo Allocca et al.
preprint
This paper addresses a methodological disparity between meditation research and research involving psychoactive substances. Studies of meditation routinely apply established criteria to distinguish expert practitioners from novices, while research with psychoactive substances screens for safety rather than classifying expertise. We analyze current benchmarking practice in meditation research,...
AbstractBackgroundResearch has shown that psychedelics may have therapeutic potential in treating mental disorders like depression and anxiety. However, the mechanisms and actions underlying their effects are still not fully understood. Similarly, while the significance of mindset and setting in shaping psychedelic experiences and therapeutic outcomes is well established, information about the...
5-MeO-DMT is a short-acting psychedelic that is anecdotally reported to induce a radical disruption of the self and a paradoxical quality of aroused, waking awareness that is nevertheless devoid of any specific perceptual contents. Here, we conducted an exploratory observational study of the phenomenological and neuronal effects of this compound. We collected micro-phenomenological interviews,...