Pharmaceutical science.
December 9, 2025
Marco Otto Toscano, Serena Chiara Civardi, Federico Durbano
Scientific interest in psychedelics, documented since the nineteenth century, has recently resurged after decades of prohibition. Contemporary research highlights their therapeutic potential in treatment-resistant psychiatric disorders, alongside their heuristic value for studying brain networks and consciousness. This chapter reviews the historical trajectory, traditional uses, mechanisms of...
Pharmaceutical science.
October 13, 2025
Berta Fumàs, David Pubill, Raúl López‐arnau et al.
Substance Use Disorder (SUD) is a chronic, relapsing mental health condition characterized by compulsive substance use despite harmful consequences. According to the World Health Organization, in 2021, approximately 39.5 million individuals worldwide suffered from drug use disorders, contributing to an estimated 600,000 deaths annually. Moreover, current pharmacological treatment, such as...
Pharmaceutical science.
August 27, 2025
Guilllermo Castaño-perez, Sara Isabel Castaño-ocampo
The resurgence of research on the use of psychedelic substances for the treatment of mental disorders and addictions has generated significant interest in the scientific and clinical communities. This chapter examines the current evidence on the efficacy, safety, and limitations of psychedelics in the treatment of these conditions. Studies investigating the use of psychedelics as monotherapy...
Pharmaceutical science.
August 19, 2025
Afshan Zeeshan Wasti
Psychedelics such as psilocybin and lysergic acid diethylamide upset the brain networks involved in self-awareness and emotion and may lead to altered perception, cognition, and social behaviour, although unsupervised use is still dangerous due to their unpredictable psychological and physiological effects. These drugs cause emotions to be amplified, the ego to dissolve, and sensory vividness...
Pharmaceutical science.
August 1, 2025
Melissa Ortega
Ayahuasca is a traditional Amazonian brew composed primarily of Banisteriopsis caapi and Psychotria viridis, drawing increasing interest for its psychedelic effects and potential therapeutic applications. Its pharmacological action is based on the synergistic combination of β-carbolines (harmine, tetrahydroharmine, and harmaline), which act as reversible inhibitors of monoamine oxidase A...