The emergence of microdosing introduced a novel approach to consuming classic psychedelic substances, such as LSD (lysergic acid diethylamide) and psilocybin mushrooms, in ways previously unconventional. Whereas traditional illicit substance use often seeks euphoric experiences, microdosing deliberately avoids such effects in favor of perceived self-enhancing benefits. Increasingly common in...
Despite its promising potential, the efficacy and safety of psilocybin in the treatment of BD depression remain unclear, and future research is essential to clarify its therapeutic value in BD.
Our results suggest that NMDAR antagonism improves alpha and beta cell function and viability, which may have translational relevance to comorbid metabolic dysfunction in depression. These mechanisms may subserve the antidepressant effects of select NMDA antagonists (e.g., ketamine/esketamine, dextromethorphan). Further research should aim to investigate the effects of subanesthetic doses of...
Adolescent depression is a significant public health concern, yet treatment options remain limited, particularly due to age- and sex-related differences in antidepressant efficacy. This study explored for the first time the potential antidepressant-like response of psilocybin in adolescence by examining acute, repeated and persistent effects in Sprague-Dawley rats of both sexes, as measured...
Os transtornos de ansiedade e a compulsão alimentar representam desafios significativos para a saúde pública global, frequentemente associados a altos índices de resistência aos tratamentos convencionais. Diante desse cenário, este estudo tem como objetivo revisar as evidências científicas sobre o uso terapêutico de plantas psicodélicas — ayahuasca, psilocibina e jurema preta — no manejo da...
Background: Senior college students face a heightened risk of mental health problems, indicating the need for effective interventions. Mindfulness-based music therapy (MBMT) has been shown to improve mental health outcomes across various populations, yet evidence of its effectiveness in senior college students remains scarce. This randomized controlled trial aimed to test the efficacy of MBMT...
There has been a renewed interest in the use of various psychedelic agents as potential therapies for multiple psychiatric conditions, including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), generalized anxiety disorder (GAD), to name a few. This follows the recent accumulation of evidence for ketamine pharmacotherapy and a rapid proliferation of clinics/programs...
BACKGROUND: Nightmares are a type of sleep disorder characterised by vivid and distressing dreams that cause abrupt awakenings, leading to significant discomfort. In adults, recurrent nightmares can negatively impact quality of life, daytime functioning, and overall mental health. In this context, it is essential to have valid, reliable, and culturally appropriate psychological instruments that...
Background: Psychedelic-assisted therapies show promise for MDD, PTSD, and addiction, yet mechanisms are often framed as 5-HT2A-centric, despite evidence of GABAergic pathology in these conditions.Hypothesis (Author Perspective): As a chemist examining psychedelic pharmacology, I propose that inhibitory-circuit modulation acts as a necessary systems-level gate converting transient 5-HT2A...
It is 60 years since ketamine was first tested in humans as an alternative but safer anaesthetic to PCP (phencyclidine) (Corssen and Domino 1966). It became widely used as the “buddy drug” for combatants in the Vietnam War: because of its great safety margin, it could be injected into wounded personnel by their buddies to relieve pain before the arrival of the medical team. Because of...