The purpose of the article: In recent years, a renewed interest has emerged in investigating the use of MDMA in the treatment of mental disorders. However, knowledge about the characteristics of recreational use of MDMA, its contexts and effects are limited. Methods: We recruited adult Norwegian participants aged 18 to 65 who reported having had a memorable experience after using MDMA. They...
Revista NeurociênciasSeptember 25, 2025Vinícius Nascimento Cavalcante Da Silva, Gisele Ferreira de Freitas, Julia Martins de Lima Moscatelli et al.
Introdução. Este trabalho investiga o potencial terapêutico do MDMA (N-Metil-3,4-Metilenodioxianfetamina) no tratamento do Transtorno Depressivo, condição psiquiátrica caracterizada por humor deprimido persistente e anedonia. A pesquisa parte da limitação dos tratamentos tradicionais, como os inibidores seletivos da recaptação da serotonina (ISRSs), que apresentam resposta lenta, podendo levar...
Psychedelics have recently grown in scientific interest, among this, there have been promising findings regarding its potential to treat a range of health problems (such as depression, anxiety, PTSD). Despite the growing research interest in psychedelics, there is little research investigating the effects of microdoses: tiny doses that produce sub-hallucinogenic effects. Additionally, there is...
Brain DisordersSeptember 23, 2025Matthew Halma, R. Levy, Joseph Varón2 citations
Clinicians and researchers are showing increased interest in psychedelic-assisted therapy for patients who don't show improvement from using conventional antidepressants. This updated review integrates recent developments, including data on lesser-studied compounds like DMT and 5-MeO-DMT, findings from large clinical trials, and evolving regulatory landscapes. In treatment-resistant depression,...
Abstract Background & Aims There are few effective treatments for methamphetamine use disorder, despite increasing global demand. Here, we assessed the safety and feasibility of outpatient psilocybin‐assisted psychotherapy for methamphetamine use disorder. Design Single arm, open label pilot study. Setting Outpatient public stimulant treatment program at St. Vincent's Hospital, Sydney,...
In recent years, the Mindfulness-Based Stress Reduction Program has been implemented in pregnant women to cope with mental problems such as anxiety and depression, reduce fear of childbirth, alleviate physical symptoms, strengthen the bond between mother and baby, increase self-compassion and self-efficacy levels, and reduce the risk of postpartum depression. Mindfulness involves paying...
Emergency department nurses face severe occupational stress leading to anxiety, depression, and burnout, which significantly impair their well-being and patient-care quality. This narrative review examined the role of mindfulness-based stress reduction (MBSR) in addressing these challenges. Rooted in nonjudgmental present-moment awareness, MBSR enhances emotional regulation and reduces...
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...
Background Depression and burnout, which are common among healthcare workers, were exacerbated by the COVID-19 pandemic. Mindfulness-Based Stress Reduction (MBSR) and psilocybin have been reported to reduce depressive symptoms, but the efficacy of the combination requires comparison to an active treatment control. We sought to evaluate the safety and preliminary efficacy of psilocybin and MBSR...