Ketamine， a non-competitive N-methyl-D-aspartate （NMDA） receptor antagonist， has gained increasing attention for its rapid antidepressant effects in treatment-resistant depression （TRD） and suicidal ideation. Its mechanisms include NMDA receptor blockade， AMPA receptor activation， and upregulation of BDNF/mTOR signaling. Its enantiomers， esketamine and R-ketamine， as well as its metabolites，...
BackgroundChronic obstructive pulmonary disease （COPD） is a common chronic respiratory disease， and patients with COPD often experience substantially emotional difficulties， such as anxiety and depression， all of which may cause serious detriment to the prognosis of patients. As a non-pharmacological intervention in clinical practice， group mindfulness-based stress reduction therapy （MBSR） is...
ObjectiveTo analyze the effects of mindfulness-based childbirth on procedural fear， pain and pregnancy outcome in pregnant women， so as to provide references for clinical application of mindfulness-based childbirth.MethodsA total of 100 pregnant women in the Third Hospital of Mianyang from January 2018 to January 2019 were selected， and divided into experimental group and control group by...