Child and Adolescent Psychiatry and Mental Health
September 14, 2023
Xiaofeng Lan, Chengyu Wang, Fan Zhang et al.
22 citations
BACKGROUND: Ketamine and its enantiomer have rapid and robust effects on depressive symptom and suicidal ideation. Little is known about their cognitive effects in adolescents. We aimed to evaluate the short-term effect of esketamine on cognition in adolescents with major depressive disorder (MDD) and suicidal ideation. METHOD: In this randomized-controlled trial, 51 participants aged 13-18...
International Journal of Multidisciplinary Approach Research and Science
September 11, 2023
Nilamani Maharana, Rupashree Goswami, Deepak Kumar Behera
3 citations
Background of the study: Stress, anxiety, and depression are rather common during higher education time and have a bad effect on academic performance. There is evidence that mindfulness practices can enhance the mental health and exist over how stress, anxiety, and depression are affected. In this study, the post-graduate students of Odisha were assessed to see how well mindfulness treated...
American Journal of Psychiatry Residents Journal
September 8, 2023
Lawrence Canale, Dhvanit Raval, Preet Chatha et al.
Psychedelics as therapeutic agents have generated significant attention from clinicians and media sources in recent years. The authors provide an update to the psychiatric trainee on the evidence for psychedelics in the treatment of major depressive disorder and treatment-resistant depression. Many modern clinical trials of the classic, serotonergic psychedelics, such as psilocybin, ayahuasca,...
Acta Psychiatrica Scandinavica
September 8, 2023
Giacomo D’andrea, Mauro Pettorruso, T. Rhee et al.
8 citations
Depressive disorders represent a significant economic and health burden globally. This is particularly evident in treatment-resistant depression (TRD), commonly defined as the absence of a satisfactory response to at least two different antidepressant trials (as defined by the U.S. Food and Drug Administration/FDA and European Medicine Agencies/EMA). The foregoing TRD cases frequently manifest...
BMC Complementary Medicine and Therapies
September 8, 2023
Chuyuan Miao, Yun Gao, Xiaohua Li et al.
19 citations
Mindfulness yoga is a type of exercise that emphasizes the integration of mindfulness or meditation into yoga. The aim of this study was to determine the effectiveness of mindfulness yoga intervention on major depressive disorder (MDD) patients. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted by searching nine databases, including PubMed, EMBASE, Web...
Clinical Psychopharmacology and Neuroscience
September 6, 2023
Julia Vendrell-Serres, Oscar Soto-Angona, Amanda Rodríguez‐Urrutia et al.
8 citations
Objective: : Treatment Resistant Depression (TRD) is commonly defined as the lack of response to two or more anti-depressants with different mechanisms of action. Up to 30% of patients diagnosed with major depressive disorder might be considered to present TRD. The objective of this study was to assess the effectiveness and tolerability of esketamine in patients diagnosed with TRD, who were...
Psychedelic Medicine
September 6, 2023
Marc J. Weintraub, Jessica K Jeffrey, Charles S. Grob et al.
4 citations
The trial will provide preliminary data on the feasibility, safety, acceptability, and psychosocial effects of PA-CBT. Results will inform randomized clinical trials to test the effects of PA-CBT for patients with depression and other mental health conditions, as well as hypotheses concerning mediating mechanisms at the cognitive and affective levels. ClinicalTrials.gov ID: NCT05227612.
Media Ilmu Kesehatan
September 1, 2023
Nanik Lestari, Ferry Efendi, Nuzul Qur'aniati et al.
Background: Globally, there is an increase in mental health issues. The prevalence of mental health issues among 10 to 19-year-olds is estimated to be 1 in 7 (14%) globally, despite the fact that most of these conditions go undiagnosed and untreated. Mindfulness techniques have been employed consistently, and has suggested associated criteria for the treatment of depression. Objective: This...
Journal of Clinical Psychopharmacology
September 1, 2023
Philip R Wang, Mani Yavi, Holim Lee et al.
Abstract: Background: Approximately one third of individuals with major depressive disorder have treatment-resistant depression (TRD). Glutamatergic modulators such as the N-methyl-d-aspartate receptor antagonist ketamine have rapid and robust antidepressant effects, but their use has been limited by accessibility and route of administration. This open-label pilot study assessed the adjunctive...
The Brown University Psychopharmacology Update
September 1, 2023
Interim results from a Phase 3 study of esketamine nasal spray in patients with treatment‐resistant depression showed no emerging safety concerns and sustained improvement in depressive symptoms. Nearly half of study participants met criteria for remission at the end of the study's optimization/maintenance phase, the investigators reported. Study results were published online May 12, 2023, in...
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
September 2023
Chan Li, Jiping Zhang, Hanhe Liu et al.
Depression is a multifactorial syndrome with a variety of underlying pathological mechanisms. While ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, exhibits a rapid antidepressant action in the central never system (CNS), the potential addiction and psychotomimetic adverse effects of ketamine limit its chronic use in clinical practice. Therefore, it is necessary to discover an...
The Brown University Psychopharmacology Update
September 1, 2023
A large‐scale open‐label trial conducted at electroconvulsive therapy (ECT) clinics has found that twice‐weekly dosing of ketamine was noninferior to three sessions a week of ECT in patients with treatment‐resistant major depression. Relapse rates during a 6‐month follow‐up period after the initial 3‐week treatment period were higher among patients receiving ECT than patients receiving...
European Journal of Investigation in Health, Psychology and Education
September 1, 2023
Monique L Mefrouche, Eva-Maria Siegmann, Stephanie Böhme et al.
15 citations
Introduction. Pregnancy is a unique time in a woman's life that can be both exciting and challenging. It is also a period that can be associated with significant stress, anxiety, and depression, which can have negative consequences for both the mother and the baby. Mindfulness interventions are known to be a well-suited treatment and prevention method for psychiatric symptoms in pregnancy, and...
International Clinical Psychopharmacology
September 1, 2023
Nicolas Garel, Michka Nazon, Kamran Naghi et al.
7 citations
Medical Aid in Dying (MAiD) is the act of a healthcare provider ending a patient's life, at their request, due to unbearable suffering from a grievous and incurable disease. Access to MAiD has expanded in the last decade and, more recently, it has been made available for psychiatric illnesses in a few countries. Recent studies have found that such psychiatric requests are rapidly increasing and...
OMEGA - Journal of Death and Dying
September 1, 2023
Hatice Karabuga Yakar, Banu Yılmaz, Emine Çelik et al.
13 citations
Mental health problems were found to be more common than physical health problems in cancer caregivers in palliative care units. This is a quasi-experimental study planned to determine the effect of the meditation based mandala programme on distress, anxiety and depression in caregivers of cancer patients in a palliative care unit. Planned as a single-group pre-test/post-test design, with a...
Pharmacology, Biochemistry, and Behavior
September 1, 2023
Yixue Qin, Haoxuan Li, Yuqi Zhang et al.
6 citations
Ketamine has been increasingly used as a rapid-onset antidepressant in specific clinical settings. However, as a psychedelic reagent, the potential of physical and psychological dependence limits its clinical use. Here, we added retigabine, a KCNQ channel opener, as an adjunctive treatment to observe its effect on ketamine's antidepressant property in a forced swim test in both male and female...
Mindfulness
September 1, 2023
Blair T Johnson, Rebecca L. Acabchuk, Elisabeth A George et al.
45 citations
Universities increasingly offer mindfulness-based programs (MBPs) to improve student health and reduce their impact on overburdened psychological services. It is critical for evidence-based policy to determine for what health outcomes mindfulness programs are effective and under what conditions. Objectives were to: (a) perform a comprehensive analysis of the effects of mindfulness interventions...
Psychiatry and Clinical Neurosciences Reports
September 1, 2023
Chisato Tanaka, Kenta Wakaizumi, Akira Ninomiya et al.
3 citations
The coronavirus disease 2019 (COVID-19) pandemic has caused unprecedented stress. Mindfulness-based interventions (MBIs) are known to be effective in reducing stress. However, it is unclear how long-term outcomes differ between those who continue mindfulness practice after MBIs and those who do not. In this study, we hypothesized that those who continued mindfulness practice would have higher...
Journal of Pain and Symptom Management
September 1, 2023
Benjamin R. Lewis, Eric L Garland, Kevin Byrne et al.
60 citations
Psilocybin-assisted psychotherapy shows promise in treating depression and existential distress in people with serious medical illness. However, its individual-based methodology poses challenges for scaling and resource availability. The HOPE trial (A Pilot Study of Psilocybin Enhanced Group Psychotherapy in Patients with Cancer) is an Institutional Review Boards-approved open-label feasibility...
Neuropsychopharmacology
September 1, 2023
Guy M. Goodwin, Megan Croal, David Feifel et al.
166 citations
Psilocybin is being investigated as a treatment in adults with treatment-resistant depression (TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for taking part in trials of psilocybin due to the possibility of ongoing antidepressant drugs altering the psychedelic effect. This phase II, exploratory, international, fixed-dose, open-label study explored the safety,...