Psychedelics as therapeutic agents have generated significant attention from clinicians and media sources in recent years. The authors provide an update to the psychiatric trainee on the evidence for psychedelics in the treatment of major depressive disorder and treatment-resistant depression. Many modern clinical trials of the classic, serotonergic psychedelics, such as psilocybin, ayahuasca,...
Sleep paralysis is a parasomnia that occurs when the muscle atonia of rapid eye movement sleep extends into wakefulness and can be accompanied by intense fear and hallucinations. The primary neurophysiological processes that lead to sleep paralysis are well known and include alterations in the gamma-aminobutyric acid, glycine, orexin, and serotonin systems. Despite a universal...