Iranian Journal of Psychiatry and Behavioral Sciences
September 23, 2015
Narges Shams-Alizadeh, Azad Maroufi, Karim Nasseri et al.
34 citations
BACKGROUND: One of the shortcomings of the available treatments for major depressive disorder (MDD) is the time delay between starting the treatment and achieving an antidepressant response. OBJECTIVES: We aimed to determine the effect of Ketamine as a synergistic antidepressant and anesthetic agent on MDD in electroconvulsive therapy (ECT). PATIENTS AND METHODS: Twenty-two patients with MDD...
International Journal of Environmental Research and Public Health
September 16, 2015
Ginette G Ferszt, Robin J Miller, Joyce E Hickey et al.
Incarcerated women enter the prison setting with remarkable histories of trauma, mental health and substance abuse issues. Given the stress of incarceration and separation from their children, families, and significant others, it is not surprising that many women experience increased anxiety, depression, and problems with sleep. Due to these negative outcomes, it is imperative to find efficient...
Journal of Affective Disorders
September 15, 2015
Wei Lin Toh, Neil Thomas, Susan L. Rossell
Auditory verbal hallucinations (AVHs) are not uncommon in bipolar disorder (BD) and major depressive disorder (MDD), but there has been scant research in the area. The current paper aims to draw together and provide a critical overview of existing studies of AVHs in BD and MDD. A systematic review was undertaken using the search terms 'hallucinations' or 'hearing voices' in conjunction with...
Irish Journal of Psychological Medicine
September 2015
T Kingston, S Collier, D Hevey et al.
Mindfulness-based cognitive therapy (MBCT) is a group-based intervention similar to mindfulness-based stress reduction, but which includes cognitive therapy techniques. This study investigates its usefulness in the treatment of depressive, anxiety and stress/distress symptoms in cancer patients referred to a psycho-oncology service. It also examines whether effect on depression is mediated by...
Journal of Affective Disorders
September 1, 2015
Fangfang Chen, Xueyu Lv, Jiliang Fang et al.
Meditation has been increasingly evaluated as an important complementary therapeutic tool for the treatment of depression. The present study employed resting-state functional magnetic resonance imaging (rs-fMRI) to examine the effect of body-mind relaxation meditation induction (BMRMI) on the brain activity of depressed patients and to investigate possible mechanisms of action for this complex...
Pharmacological Research
September 2015
R Rajkumar, J Fam, E Y M Yeo et al.
Depression and suicide are known to be intricately entwined but the neurobiological basis underlying this association is yet to be understood. Ketamine is an N-methyl d-aspartate (NMDA) receptor antagonist used for induction and maintenance of general anaesthesia but paradoxically its euphoric effects lead to its classification under drugs of abuse. The serendipitous finding of rapid-onset...
Journal of Consulting and Clinical Psychology
August 24, 2015
Thorsten Barnhofer, Catherine Crane, Kate Brennan et al.
Objective: In patients with a history of suicidal depression, recurrence of depressive symptoms can easily reactivate suicidal thinking. In this study, we investigated whether training in mindfulness, which is aimed at helping patients “decenter” from negative thinking, could help weaken the link between depressive symptoms and suicidal cognitions. Method: Analyses were based on data from a...
Psychiatria Danubina
August 20, 2015
Kim Rod
BACKGROUND People whose chronic pain limits their independence are especially likely to become anxious and depressed. Mindfulness training has shown promise for stress-related disorders. METHODS Chronic pain patients who complained of anxiety and depression and who scored higher than moderate in Hamilton Depression Rating Scale (HDRS) and Hospital Anxiety and Depression Scale (HADS) as well as...
Indian Journal of Pharmacology
July 1, 2015
Girish H. Banwari, Prutha B Desai, P. Patidar
There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or...
Biological Psychiatry
July 1, 2015
Peter Nagele, Andreas Duma, Michael Kopec et al.
N-methyl-D-aspartate receptor antagonists, such as ketamine, have rapid antidepressant effects in patients with treatment-resistant depression (TRD). We hypothesized that nitrous oxide, an inhalational general anesthetic and N-methyl-D-aspartate receptor antagonist, may also be a rapidly acting treatment for TRD. In this blinded, placebo-controlled crossover trial, 20 patients with TRD were...
BioMed Research International
June 7, 2015
Alessandro Grecucci, Edoardo Pappaianni, Roma Siugzdaite et al.
The purpose of this paper is to review some of the psychological and neural mechanisms behind mindfulness practice in order to explore the unique factors that account for its positive impact on emotional regulation and health. After reviewing the mechanisms of mindfulness and its effects on clinical populations we will consider how the practice of mindfulness contributes to the regulation of...
Mindfulness
June 1, 2015
Stuart J. Eisendrath, Erin P Gillung, Kevin L. Delucchi et al.
Major depressive disorder (MDD) is the leading cause of disability in the developed world, yet broadly effective treatments remain elusive. The primary aim of this pilot study was to investigate the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) monotherapy, compared to sertraline monotherapy, for patients with acute MDD. This open-label, nonrandomized controlled trial examined a MBCT...
Journal of Religion and Health
June 1, 2015
Lisa Miller, Yakov A Barton
Diagnosis of depression has low reliability (kappa = 0.28) due to "covert heterogeneity," making the identification of sub-types a focus of research. Very high rates of moderate or sub-threshold depression among adolescents (35-45 % beyond the 20-25 % with MDD), prompt consideration of a potential sub-type of moderate sub-threshold depression, linked to adolescent development. Previously,...
Psikiyatride Güncel Yaklaşımlar
May 31, 2015
Feride Karacaer
Standart antidepressants are needed for the many individuals with major depressive disorder. However they do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent studies show that subanesthetic dose of ketamine is efficacy and safety for the treatment of depression. Antidepressant effects of ketamine have been found to be...
May 6, 2015
S. Best
Treatment resistant depression (TRD) is a major public health issue, with comorbid OCD contributing to the general medical costs and severity associated with TRD. Recent research has investigated the efficacy of transcranial magnetic stimulation (TMS and its variant rTMS) in ameliorating the symptoms of depression and OCD. Most studies have used TMS to facilitate electromagnetic stimulation of...
Current Molecular Medicine
May 4, 2015
Yuta Ohgi, Takashi Futamura, Kenji Hashimoto
109 citations
Glutamate, a major excitatory neurotransmitter, plays important roles in synaptic plasticity, such as long-term potentiation (LTP) and new synapse formation. Growing evidence suggests that glutamate signaling is involved in the neurobiology of psychiatric disorders, including schizophrenia, major depressive disorder (MDD) and bipolar disorder (BP). Postmortem brain studies demonstrated altered...
The Journal of Clinical Psychiatry
May 2015
Chittaranjan Andrade
Intranasal drug delivery (INDD) systems offer a route to the brain that bypasses problems related to gastrointestinal absorption, first-pass metabolism, and the blood-brain barrier; onset of therapeutic action is rapid, and the inconvenience and discomfort of parenteral administration are avoided. INDD has found several applications in neuropsychiatry, such as to treat migraine, acute and...
American Journal of Lifestyle Medicine
May 1, 2015
Nicole D. White
Mindfulness-based cognitive therapy (MBCT) teaches the patient to recognize a deteriorating mood with the goal of avoiding self-perpetuating patterns of ruminative, negative thoughts and thus depressive disorders. MBCT was initially conceived as an intervention to prevent relapse of major depression, but it has since been studied in patients with current episodes of depression. MBCT has been...
Psychiatry Research
April 30, 2015
Alberto Chiesa, Vittoria Castagner, Costanza Andrisano et al.
Mindfulness-based cognitive therapy (MBCT) showed efficacy for currently depressed patients. However, most of the available studies suffer from important methodological shortcomings, including the lack of adequate control groups. The present study aims to compare MBCT with a psycho-educational control group designed to be structurally equivalent to the MBCT program but excluding the main...
Psychological Trauma: Theory, Research, Practice and Policy
April 27, 2015
Autumn M Gallegos, Megan C Lytle, Jan A Moynihan et al.
This study examined the effects of a mindfulness-based stress reduction (MBSR) program on psychological functioning and inflammatory biomarkers in women with histories of interpersonal trauma. The 8-week MBSR program was conducted at a community-based health center and participants (N = 50) completed several measures of psychological functioning at study entry as well as 4 weeks, 8 weeks, and...