Indian Journal of Pharmacology
July 1, 2025
J V Ashwin, Mohit Kumar Shahi, Astha Singh et al.
This network meta-analysis evaluated the efficacy and safety of the dextromethorphan-bupropion combination (AXS-05) in treating major depressive disorder (MDD). Data were retrieved from multiple databases, including PubMed, Embase, Scopus, Google Scholar, and ClinicalKey, yielding 60 records. After removing duplicates and excluding irrelevant studies, such as reviews, case reports, posters, and...
Indian Journal of Pharmacology
July 1, 2015
Girish H. Banwari, Prutha B Desai, P. Patidar
There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or...
Indian Journal of Pharmacology
November 1, 2008
Drug development is an activity that is long, complex and expensive. In 2004, attrition in the drug development paradigm prompted the US Food and Drug Administration (FDA) to introduce its 'Critical Path' document, which highlighted the serious discordance between major scientific advances and limited drug development process. One issue addressed was that of microdosing. The concept of...
Indian Journal of Pharmacology
April 1, 1994
Stephen E.D. Nsimba, J.P. Kelly, B.e. Leonard
Phencyclidine (PCP). a psychotomimetic drug, interferes with glutamate transmission at the N-methyl-D-aspartate receptors in the central nervous system and precipitates psychotic reaction in humans which are similar to schizophrenia. The present study investigates whether surgical removal of the olfactory bulbs (0B) in rats could produce an effect or a deficit in the NMDA receptors in the...