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Chittaranjan Andrade

7 papers in the library · 88 citations · publishing 2010-2026

Papers

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Oral ketamine for rapid reduction of suicidal ideation in major depressive disorder: A midazolam-controlled randomized clinical trial.

Asian Journal of Psychiatry April 1, 2025 Asif Seraj, Mohammed Reyazuddin, R K Gaur et al. 11 citations

The simplest, most convenient, and least expensive way to treat depressed and suicidal patients with ketamine is to administer racemic ketamine by the oral route. We describe the first active-controlled randomized clinical trial of oral racemic ketamine for suicidal ideation associated with depression. Adult patients with major depressive disorder and expressed suicidal ideation were randomized...

Randomized Controlled Trials of Psilocybin‐Assisted Therapy in the Treatment of Major Depressive Disorder: Systematic Review and Meta‐Analysis

Acta Psychiatrica Scandinavica December 3, 2024 Vikas Menon, Parthasarathy Ramamurthy, Sandesh Venu et al. 15 citations

ABSTRACT Introduction There is growing interest in the use of psychedelic‐assisted therapy (PAT) for major depressive disorder (MDD), including treatment‐resistant depression. We used randomized controlled trial (RCT) data to compare summary estimates of change in depression ratings with PAT versus comparator treatments in MDD. We also compared response and remission rates, and adverse effects....

A randomised, open-label, pragmatic pilot comparison of oral and intravenous ketamine in treatment-resistant depression.

Asian Journal of Psychiatry September 1, 2024 Pn Suresh Kumar, Vikas Menon, Chittaranjan Andrade 12 citations

For depression, ketamine is more conveniently administered by oral than by intravenous (iv) routes. The relative antidepressant efficacy of oral vs iv ketamine is unknown. To assess the acute efficacy and the persistence of improvement with open-label oral versus iv ketamine in outpatients with treatment-resistant depression (TRD). Adults with TRD were randomized to oral (N=30) or IV (N=31)...

Ketamine vs Electroconvulsive Therapy for Major Depressive Episode

JAMA Psychiatry June 1, 2023 Vikas Menon, Natarajan Varadharajan, Abdul Faheem et al. 50 citations

ImportanceThe relative efficacy of ketamine and electroconvulsive therapy (ECT) in adults with major depressive episode (MDE) needs clarification.ObjectiveTo compare depression rating outcomes with ketamine vs ECT in adults with MDE and to compare response and remission rates, number of sessions to response and remission, and adverse effects.Data SourcesTwo investigators independently...

Innovative approaches to treatment - refractory depression: The ketamine story

Indian Journal of Psychiatry April 1, 2010 T. Rao, Chittaranjan Andrade

Byline: T.S. Rao, Chittaranjan. Andrade Antidepressant drugs have traditionally addressed the monoamine triumvirate: serotonin, noradrenaline, and dopamine. There have been predominantly two mechanisms recruited in drug action - inhibition of monoamine reuptake and inhibition of intravesicular monoamine catabolism. Tianeptine, which increases the synaptic reuptake of serotonin, and mirtazapine,...