Cerebral Cortex
March 7, 2011
Elizabeth C. Mormino, Andre Smiljic, Amynta O. Hayenga et al.
349 citations
Although beta-amyloid (Aβ) deposition is a characteristic feature of Alzheimer's disease (AD), this pathology is commonly found in elderly normal controls (NC). The pattern of Aβ deposition as detected with Pittsburgh compound-B positron emission tomography (PIB-PET) imaging shows substantial spatial overlap with the default mode network (DMN), a group of brain regions that typically...
Journal of Neuroscience
March 2, 2011
Robert Leech, Salwa Kamourieh, Christian Beckmann et al.
801 citations
The posterior cingulate cortex (PCC) is a central part of the default mode network (DMN) and part of the structural core of the brain. Although the PCC often shows consistent deactivation when attention is focused on external events, anatomical studies show that the region is not homogeneous, and electrophysiological recordings in nonhuman primates suggest that it is directly involved in some...
Brain and Cognition
March 2011
Andrew A Fingelkurts, Alexander A Fingelkurts
Based on the theoretical analysis of self-consciousness concepts, we hypothesized that the spatio-temporal pattern of functional connectivity within the default-mode network (DMN) should persist unchanged across a variety of different cognitive tasks or acts, thus being task-unrelated. This supposition is in contrast with current understanding that DMN activated when the subjects are resting...
Cerebral Cortex
February 17, 2011
Philipp G. Sämann, Renate Wehrle, David Hoehn et al.
408 citations
Falling asleep is paralleled by a loss of conscious awareness and reduced capacity to process external stimuli. Little is known on sleep-associated changes of spontaneously synchronized anatomical networks as detected by resting-state functional magnetic resonance imaging (rs-fMRI). We employed functional connectivity analysis of rs-fMRI series obtained from 25 healthy participants, covering...
Neurology
January 13, 2011
Jeffrey R. Petrella, Forrest Sheldon, Steven E. Prince et al.
291 citations
OBJECTIVE: Dysfunction of the default mode network (DMN) has been identified in prior cross-sectional fMRI studies of Alzheimer disease (AD) and mild cognitive impairment (MCI); however, no studies have examined its utility in predicting future cognitive decline. METHODS: fMRI scans during a face-name memory task were acquired from a cohort of 68 subjects (25 normal control, 31 MCI, and 12 AD)....
Frontiers in Computational Neuroscience
2011
Romero Eduardo
Event Abstract Back to Event A Multi-Scale Analysis to set the Default Mode Network in noisy fMRI data Katherine Baquero1*, Francisco Gómez2, Andrea Soddu2, Audrey Vanhaudenhuyse2, Athena Demertzi2, Jean-Flory Tshibanda3, Olivia Gosseries2, Quentin Noirhomme2, Steven Laureys2 and Eduardo Romero1* 1 National University of Colombia, Biomedical Engineering, Colombia 2 University of Liege,...
Behavioural Neurology
2011
Nathan B Danielson, Jennifer N Guo, Hal Blumenfeld
The default mode network has been hypothesized based on the observation that specific regions of the brain are consistently activated during the resting state and deactivated during engagement with task. The primary nodes of this network, which typically include the precuneus/posterior cingulate, the medial frontal and lateral parietal cortices, are thought to be involved in introspective and...
Human Brain Mapping
2011
Qing Jiao, Guangming Lu, Zhiqiang Zhang et al.
Although the brain areas in the default-mode network (DMN) act in a coordinated way during rest, the activity levels in the individual areas of the DMN are highly heterogeneous. The relation between the activity levels and the pattern of causal interaction among the DMN areas remains unknown. In the present fMRI study, seven nodes of the DMN were identified and their activity levels were...
The open neuroimaging journal
2011
Tadashi Ino, Ryusuke Nakai, Takashi Azuma et al.
Recent neuroimaging studies have suggested that brain regions activated during retrieval of autobiographical memory (ABM) overlap with the default mode network (DMN), which shows greater activation during rest than cognitively demanding tasks and is considered to be involved in self-referential processing. However, detailed overlap and segregation between ABM and DMN remain unclear. This fMRI...
Journal of Visualized Experiments
December 28, 2010
Mark A Halko, Mark C Eldaief, Jared C Horvath et al.
The default mode network is a group of brain regions that are active when an individual is not focused on the outside world and the brain is at "wakeful rest." It is thought the default mode network corresponds to self-referential or "internal mentation". It has been hypothesized that, in humans, activity within the default mode network is correlated with certain pathologies (for instance,...