Journal of Psychopharmacology
June 19, 2025
David Weigner, Marvin Sören Meiering, Anne Weigand et al.
Neuroimaging studies have linked the beneficial effects of subanaesthetic ketamine doses in psychiatric conditions characterized by chronic stress pathology (CSP) to altered functional connectivity (FC) within the pregenual anterior cingulate cortex (pgACC). Previous research indicates a potential role of glutamate concentration in FC changes; however, the precise relationship between glutamate...
bioRxiv
May 21, 2025
Mariana Pereira, Paola Galdi, Ting Mei et al.
preprint
Dreaming represents a complex and universal aspect of human sleep, yet it remains an intriguing phenomenon, with the neural mechanisms underlying dream experiences and their frequency not fully understood. This study employs a multimodal neuroimaging approach, integrating quantitative multi-parameter mapping, diffusion tensor imaging, and resting-state functional MRI, to investigate the neural...
Translational Psychiatry
October 14, 2024
Marvin S Meiering, David Weigner, Matti Gärtner et al.
4 citations
Ketamine is a highly effective antidepressant (AD) that targets the glutamatergic system and exerts profound effects on brain circuits during negative emotional processing. Interestingly, the effects of ketamine on brain measures are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release. Examining the antagonistic effects of ketamine and lamotrigine on...
Translational Psychiatry
June 18, 2024
Matti Gärtner, Anne Weigand, Marvin Sören Meiering et al.
1 citation
Neuroimaging studies have identified the anterior cingulate cortex (ACC) as one of the major targets of ketamine in the human brain, which may be related to ketamine's antidepressant (AD) mechanisms of action. However, due to different methodological approaches, different investigated populations, and varying measurement timepoints, results are not consistent, and the functional significance of...
Neuropsychopharmacology
May 25, 2023
Matti Gärtner, Anne Weigand, Marvin Sören Meiering et al.
There is intriguing evidence suggesting that ketamine might have distinct acute and delayed neurofunctional effects, as its acute administration transiently induces schizophrenia-like symptoms, while antidepressant effects slowly emerge and are most pronounced 24 h after administration. Studies attempting to characterize ketamine's mechanism of action by using blood oxygen level dependent...
Neuropsychobiology
2023
Matti Gärtner, Anne Weigand, Christian Keicher et al.
Cognition and emotion are fundamentally integrated in the brain and mutually contribute to behavior. The relation between working memory (WM) and emotion is particularly suited to investigate cognition-emotion interaction since WM is an essential component of many higher cognitive functions. Ketamine affects not only WM but also has a profound impact on emotional processing. Effects of acute...
Journal of Neuroscience
March 2, 2011
Robert Leech, Salwa Kamourieh, Christian Beckmann et al.
801 citations
The posterior cingulate cortex (PCC) is a central part of the default mode network (DMN) and part of the structural core of the brain. Although the PCC often shows consistent deactivation when attention is focused on external events, anatomical studies show that the region is not homogeneous, and electrophysiological recordings in nonhuman primates suggest that it is directly involved in some...
N.C.J. Müller, Martin Dresler, G. Janzen et al.
preprint
Abstract In the last few years the involvement of the medial prefrontal cortex (mPFC) in memory processing has received increased attention. It is centrally involved when we use prior knowledge (schemas) to improve learning of new material. With the mPFC also being one of the core hubs of the default mode network (DMN) and the DMN’s role in memory retrieval, we decided to investigate whether...