Neuroimage
December 17, 2009
Zhigang Qi, Xia Wu, Zhiqun Wang et al.
328 citations
Mild cognitive impairment (MCI) is the transitional, heterogeneous continuum from healthy elderly to Alzheimer's disease (AD). Previous studies have shown that brain functional activity in the default mode network (DMN) is impaired in AD patients. However, altering DMN activity patterns in MCI patients remains largely unclear. The present study utilized resting-state functional magnetic...
Journal of Neuroscience
November 18, 2009
Angela R. Laird, Simon B. Eickhoff, Karl Li et al.
577 citations
The default mode network (DMN) comprises a set of regions that exhibit ongoing, intrinsic activity in the resting state and task-related decreases in activity across a range of paradigms. However, DMN regions have also been reported as task-related increases, either independently or coactivated with other regions in the network. Cognitive subtractions and the use of low-level baseline...
Neuroimage
October 29, 2009
Stefan J. Teipel, Arun L.w. Bokde, Thomas Meindl et al.
205 citations
Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional connectivity pattern is still widely unexplored. We combined fractional anisotropy measures of fiber tract integrity derived from diffusion tensor imaging (DTI) and resting...
Biological Psychiatry
October 15, 2009
Yvette I. Sheline, Marcus E. Raichle, Abraham Z. Snyder et al.
608 citations
BackgroundImportant functional connections within the default mode network (DMN) are disrupted in Alzheimer's disease (AD), likely from amyloid-beta (Abeta) plaque-associated neuronal toxicity. Here, we sought to determine if pathological effects of Abeta amyloid plaques could be seen, even in the absence of a task, by examining functional connectivity in cognitively normal participants with...
Journal of Neuroscience
September 1, 2009
Kurt E Weaver, Andrew G Richardson
The medial prefrontal cortex (mPFC), which encompasses the anterior paracingulate cortex and extends rostrally along the medial frontal wall, has recently received a considerable amount of scientific inquiry as a distinct subregion of the frontal lobe. This is, in part, because the mPFC is involved
Journal of Cognitive Neuroscience
July 6, 2009
R. Nathan Spreng, Cheryl L. Grady
1,023 citations
The ability to rise above the present environment and reflect upon the past, the future, and the minds of others is a fundamentally defining human feature. It has been proposed that these three self-referential processes involve a highly interconnected core set of brain structures known as the default mode network (DMN). The DMN appears to be active when individuals are engaged in...
PLoS One
June 30, 2009
Dardo G. Tomasi, Nora D. Volkow, Ruiliang Wang et al.
Background Dopamine and dopamine transporters (DAT, which regulate extracellular dopamine in the brain) are implicated in the modulation of attention but their specific roles are not well understood. Here we hypothesized that dopamine modulates attention by facilitation of brain deactivation in the default mode network (DMN). Thus, higher striatal DAT levels, which would result in an enhanced...
Proceedings of the National Academy of Sciences
June 19, 2009
Silvina G. Horovitz, Allen R. Braun, Walter S. Carr et al.
706 citations
The recent discovery of a circuit of brain regions that is highly active in the absence of overt behavior has led to a quest for revealing the possible function of this so-called default-mode network (DMN). A very recent study, finding similarities in awake humans and anesthetized primates, has suggested that DMN activity might not simply reflect ongoing conscious mentation but rather a more...
PLoS One
May 28, 2009
Chao‐gan Yan, Dongqiang Liu, Yong He et al.
315 citations
BACKGROUND: Recent functional MRI (fMRI) studies have demonstrated that there is an intrinsically organized default mode network (DMN) in the resting brain, primarily made up of the posterior cingulate cortex (PCC) and the medial prefrontal cortex (MPFC). Several previous studies have found that the DMN is minimally disturbed during different resting-state conditions with limited cognitive...
Cortex
May 18, 2009
Jiongjiong Yang, Xuchu Weng, Yufeng Zang et al.
Recent neuroimaging studies have shown that several brain regions--namely, the posterior cingulate cortex (PCC), ventral medial prefrontal cortex (vmPFC), and the bilateral angular gyrus--are more active during resting states than during cognitive tasks (i.e., default mode network). Although there is evidence showing that the default mode network is associated with unconscious state, it is...