Journal of Visualized Experiments
May 29, 2026
Tommi Kiiso, Paula Partanen, Keyrstin Jacobs et al.
The default mode network (DMN) is a central, large-scale brain network implicated in a range of cognitive functions and neuropsychiatric disorders, such as major depressive disorder (MDD). Studying the DMN's complex dynamics in animal models provides invaluable insights into its function in both healthy and pathological states. However, performing stable, long-term, large-scale...
Journal of Visualized Experiments
January 9, 2026
Tingjun Zhang, Shujuan Yan, Hui Wang et al.
While perioperative esketamine use has grown increasingly prevalent, evidence supporting its efficacy and safety in elderly patients undergoing laparoscopic prostate cancer surgery remains limited. This retrospective study evaluated intravenous esketamine's performance in this population by analyzing 186 elderly patients treated between 2021 and 2024, divided into a control group (n = 91;...
Journal of Visualized Experiments
August 1, 2025
Kwang-Mook Jung, Alex Mabou Tagne, Heidi C Avalos et al.
Δ9-tetrahydrocannabinol (THC) is responsible for the intoxicating (psychotropic) effects of cannabis and cannabis-derived products currently available in the legal and illegal markets. The psychotropic effects of THC are produced via activation of CB1 cannabinoid receptors in the brain, which are normally engaged by endogenous cannabinoid (endocannabinoid) substances. Outside the brain, THC...
Journal of Visualized Experiments
July 14, 2023
Yan Yue, Min Deng, Shunqi Liao et al.
Diabetic peripheral neuropathy (DPN) is one of the most prevalent chronic complications of diabetes. One of its crucial therapy approaches is mind-body exercise. Recently, various exercise modalities, including stepping, resistance, aerobics, balance, and whole-body vibration, were investigated to construct the most suitable form of exercise for patients with DPN. The purpose of this study is...
Journal of Visualized Experiments
May 11, 2020
Erika Nyhus, William A. Engel, Tomas Donatelli Pitfield et al.
17 citations
Although there has been recent interest in how mindfulness meditation can affect episodic memory as well as brain structure and function, no study has examined the behavioral and neural effects of mindfulness meditation on episodic memory. Here we present a protocol that combines mindfulness meditation training, an episodic memory task, and EEG to examine how mindfulness meditation changes...
Journal of Visualized Experiments
March 8, 2019
Mai Minoura, Iori Tani, Takahiro Ishii et al.
How is our bodily self-consciousness acquired, and how does it affect cognition? To investigate this, we conducted an experiment using the squeeze machine, a device that provides pressure along the length of the user's whole body. The squeeze machine is used to help autistic people relax. The inventor of the machine, Dr. Temple Grandin says that the squeeze machine, beyond bringing her...
Journal of Visualized Experiments
January 22, 2018
Robert Carter, Kirtigandha Salwe Carter, John Holliday et al.
A pragmatic breath-based intervention to benefit human performance and stress management is timely and valuable to individuals seeking holistic approaches for emotional regulation and optimizing compensatory reserve mechanisms. This protocol is designed to not only teach mind-body awareness but also to provide feedback utilizing physiological data and survey results. The primary findings of...
Journal of Visualized Experiments
January 13, 2018
Andria Pelentritou, Levin Kuhlmann, John Cormack et al.
Anesthesia arguably provides one of the only systematic ways to study the neural correlates of global consciousness/unconsciousness. However to date most neuroimaging or neurophysiological investigations in humans have been confined to the study of γ-Amino-Butyric-Acid-(GABA)-receptor-agonist-based anesthetics, while the effects of dissociative...
Journal of Visualized Experiments
May 10, 2017
Hin Hung Sik, Junling Gao, Jicong Fan et al.
In both the East and West, traditional teachings say that the mind and heart are somehow closely correlated, especially during spiritual practice. One difficulty in proving this objectively is that the natures of brain and heart activities are quite different. In this paper, we propose a methodology that uses wavelet entropy to measure the chaotic levels of both electroencephalogram (EEG) and...
Journal of Visualized Experiments
July 9, 2016
Terrell Holloway, José L. Moreno, Javier González-Maeso
The heteromeric receptor complex between 5-HT2A and mGlu2 has been implicated in some of the behavioral phenotypes in mouse models of psychosis(1,2). Consequently, investigation of structural details of the interaction between 5-HT2A and mGlu2 affecting schizophrenia-related behaviors represents a powerful translational tool. As previously shown, the head-twitch response (HTR) in mice is...
Journal of Visualized Experiments
July 1, 2015
Maryanna Klatt, Beth Steinberg, Anne-Marie Duchemin
A pragmatic mindfulness intervention to benefit personnel working in chronically high-stress environments, delivered onsite during the workday, is timely and valuable to employee and employer alike. Mindfulness in Motion (MIM) is a Mindfulness Based Intervention (MBI) offered as a modified, less time intensive method (compared to Mindfulness-Based Stress Reduction), delivered onsite, during...
Journal of Visualized Experiments
December 28, 2010
Mark A Halko, Mark C Eldaief, Jared C Horvath et al.
The default mode network is a group of brain regions that are active when an individual is not focused on the outside world and the brain is at "wakeful rest." It is thought the default mode network corresponds to self-referential or "internal mentation". It has been hypothesized that, in humans, activity within the default mode network is correlated with certain pathologies (for instance,...