Granger causal influence predicts BOLD activity levels in the default mode network.
Qing Jiao, Guangming Lu, Zhiqiang Zhang, Yuan Zhong, Zhengge Wang, Yongxin Guo, Kai Li, Mingzhou Ding, Yijun Liu
Human Brain Mapping 2011 DOI: 10.1002/hbm.21065 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational fMRI study Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Nerve net Neurons Humans Magnetic resonance imaging Brain mapping Image processing, computer-assisted Adult Female |
| Key findings | Activity levels across seven default-mode network nodes showed a consistent hierarchy, highest in posterior cingulate/precuneus and lowest in left inferior temporal gyrus. Activity levels correlated significantly with In-Out degrees of Granger causal information flow, suggesting Granger causal influences can predict BOLD activity levels. |
Abstract
Although the brain areas in the default-mode network (DMN) act in a coordinated way during rest, the activity levels in the individual areas of the DMN are highly heterogeneous. The relation between the activity levels and the pattern of causal interaction among the DMN areas remains unknown. In the present fMRI study, seven nodes of the DMN were identified and their activity levels were rank-ordered based on a power spectral analysis of the resting blood oxygenation level-dependent (BOLD) signals. Furthermore, the direction of information flow among these DMN nodes was determined using Granger causality analysis and graph-theoretic methods. We found that the activity levels in these seven DMN nodes had a highly consistent hierarchical distribution, with the highest activity level in the posterior cingulate/precuneus cortices, followed by ventral medial prefrontal cortex and dorsal medial prefrontal cortex, and with the lowest level in the left inferior temporal gyrus. Importantly, a significant correlation was found between the activity levels and the In-Out degrees of information flow across the DMN nodes, suggesting that Granger causal influences can be used to predict BOLD activity levels. These findings shed light on the dynamical organization of cortical neuronal networks and may provide the basis for characterizing network disruption by brain disorders.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cited by 7
- Impact of meditation training on the default mode network during a restful state Social Cognitive and Affective Neuroscience March 24, 2012
- Posteromedial cortex glutamate and GABA predict intrinsic functional connectivity of the default mode network Neuroimage September 18, 2012
- Impact of sample size and regression of tissue‐specific signals on effective connectivity within the core default mode network Human Brain Mapping September 15, 2023
- Effect of mindfulness meditation on the neural substrates of emotion processing and resting state in experienced and beginner meditators Papyrus : Institutional Repository (Université de Montréal) July 1, 2011
- Altered dynamic effective connectivity of the default mode network in type 2 diabetes Frontiers in Neurology January 15, 2024
and 2 more in the library
Cites 5
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Human Brain Mapping January 24, 2008
- Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling Journal of Neuroscience November 18, 2009
- Spontaneous Brain Activity in the Default Mode Network Is Sensitive to Different Resting-State Conditions with Limited Cognitive Load PLoS One May 28, 2009
- Functional connectivity in the resting brain: A network analysis of the default mode hypothesis Proceedings of the National Academy of Sciences December 27, 2002