Brain activation during autobiographical memory retrieval with special reference to default mode network.
Tadashi Ino, Ryusuke Nakai, Takashi Azuma, Toru Kimura, Hidenao Fukuyama
The open neuroimaging journal 2011 DOI: 10.2174/1874440001105010014 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational fMRI study Peer reviewed |
|---|---|
| Topics | Default mode network |
| Keywords | Autobiographical memory Functional MRI. Semantic memory |
| Key findings | Autobiographical memory retrieval engaged regions overlapping substantially with the default mode network, and regions specifically devoted to autobiographical memory were left-lateralized and mostly within that network. |
Abstract
Recent neuroimaging studies have suggested that brain regions activated during retrieval of autobiographical memory (ABM) overlap with the default mode network (DMN), which shows greater activation during rest than cognitively demanding tasks and is considered to be involved in self-referential processing. However, detailed overlap and segregation between ABM and DMN remain unclear. This fMRI study focuses first on revealing components of the DMN which are related to ABM and those which are unrelated to ABM, and second on extracting the neural bases which are specifically devoted to ABM. Brain activities relative to rest during three tasks matched in task difficulty assessed by reaction time were investigated by fMRI; category cued recall from ABM, category cued recall from semantic memory, and number counting task. We delineated the overlap between the regions that showed less activation during semantic memory and number counting relative to rest, which correspond to the DMN, and the areas that showed greater or less activation during ABM relative to rest. ABM-specific activation was defined as the overlap between the contrast of ABM versus rest and the contrast of ABM versus semantic memory. The fMRI results showed that greater activation as well as less activation during ABM relative to rest overlapped considerably with the DMN, indicating that the DMN is segregated to the regions which are functionally related to ABM and the regions which are unrelated to ABM. ABM-specific activation was observed in the left-lateralized brain regions and most of them fell within the DMN.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Dynamic reconfiguration of the default mode network during narrative comprehension Human subjects | 2016 | Experimental study | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis |
Citations in the library
Cites 7
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Human Brain Mapping January 24, 2008
- Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Journal of Cognitive Neuroscience July 6, 2009
- The default-mode, ego-functions and free-energy: a neurobiological account of Freudian ideas Brain February 28, 2010
- Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling Journal of Neuroscience November 18, 2009
and 2 more in the library