This methodological preprint presents a neurophenomenological calibration protocol for first-person validation of contemplative practices. The core hypothesis: the cognitive register "where am I?" combined with a somatic anchor (Nabho-mudra: tongue to soft palate) switches attention from narrative self-referential processing (DMN) to configurational, non-evaluative presence (SN/CEN balance)....
Biological Quantum-Analogous Cognition (BQAC) is a theoretical framework proposingthatconsciousnessisbestunderstoodasabiologicallyevolvedprocessformanagingunresolvedpossibilities under conditions of uncertainty. BQAC does not claim that the brain is literallyquantum mechanical, that cognition depends on macroscopic quantum computation, or thatconsciousness requires exotic physical substrates....
Consciousness is often theorized as a property of the brain's instantaneous information-processing architecture. We argue that this "snapshot" approach systematically fails to account for the feeling of mineness and temporal continuity that characterize conscious experience. We propose the Judge-Adjudication Model (JAM), in which consciousness is a dynamic structure: the Judge is a...
Aging is associated with chronic, low-grade inflammation ("inflammaging"), which contributes to neuropsychiatric and neurodegenerative disorders such as depression, Alzheimer's disease, and Parkinson's disease. Conventional pharmacotherapies often provide limited benefit in older adults and are further complicated by polypharmacy and drug-drug interactions. Psilocybin, a serotonergic...
Background The Indian Knowledge Systems (IKS) and the traditions of yoga provide us with a complete insight into the mind, cognition, and consciousness. Nevertheless, the frameworks are not very connected with the modern neuroscience, which restricts their scientific integration and use in cognitive and mental health studies. Objective The objective of the paper is to come up with a composite...
This paper explores how meditation serves as a tool to modulate and reconfigure the cognitive boundary between the subjective self and objective reality. By integrating Cognitive Constructivism (CC)—which views the mind as a "prediction machine" that constructs experienced reality—with Existential Realism (ER)—which emphasizes the primacy of the immediate "now"—the study examines the...
Resuscitation PlusMay 1, 2026José Alonso Ruiz, Mayte Rodríguez-González-Moro, Tomás Segura et al.
This observational study examined brain activation patterns when people relive their memories of recalled experiences of death (REDs), also known as authentic near-death experience (NDE) memories, using structural and functional MRI under normal cerebral perfusion in participants with clinically documented life-threatening events and loss of consciousness. Fifteen participants (7 women, 8 men;...
Ketamine produces rapid antidepressant effects in a subset of patients with treatment-resistant depression, yet neuroimaging findings have been difficult to integrate because studies differ in imaging modality, analytic approach, task context, and post-infusion timing. To address this, we conducted a multimodal synthesis of functional magnetic resonance imaging (fMRI) and positron emission...
Ancient contemplative traditions offer sophisticated technologies for cultivating stable states of consciousness underlying sustainable well-being. This integrative review synthesizes empirical and theoretical literature on Patañjali’s Sanyam—the integrated practice of Dharana (concentration), Dhyana (meditative absorption), and Samadhi (non-dual awareness)—and its Zen parallel, Joriki...
Methamphetamine (MA) use disorder is associated with widespread disruption of large-scale brain networks involved in cognitive control, attention, and salience processing. Resting-state functional MRI (rs-fMRI) provides a means to characterize these alterations; however, little is known about the capacity for functional network reorganization following targeted intervention. The purpose of this...