Human Brain Mapping
June 15, 2026
Adam Coates, Paul Sedlmayr, Anna Wastian et al.
The human claustrum is a small bilateral grey matter structure that is highly interconnected with cortical and subcortical regions. It has been implicated in different functions including sleep, multisensory integration, consciousness and attention, yet its exact function remains unclear. The primate claustrum is known to have distinct sensory regions, with the visual zone recently demonstrated...
Human Brain Mapping
June 1, 2026
Chenfei Ye, Ziyan Deng, Shiqing Cong et al.
The human brain exhibits inherent multistability, with Energy Landscape Analysis (ELA) providing effective frameworks for investigating this property through BOLD signals. However, traditional amplitude-based approaches fundamentally neglect critical phase synchronization dynamics that mediate large-scale neural coordination, while existing phase-based methods like Leading Eigenvector Dynamic...
Human Brain Mapping
April 1, 2026
Paweł Orłowski, Aleksandra Domagalik, Michał Bola
Classic psychedelics profoundly alter emotional states, inducing intense acute experiences lasting hours, followed by subtler, longer-lasting changes in emotional reactivity that can persist for weeks. While experimental and clinical studies document these prolonged effects, the highly context-dependent nature of psychedelic experiences leaves open the question of whether naturalistic,...
Human Brain Mapping
June 1, 2025
Wataru Sato, Takanori Kochiyama, Shota Uono
1 citation
Happiness is a subjective experience that can serve as the ultimate goal for humans. A recent study that employed resting-state functional magnetic resonance imaging (fMRI) reported that spontaneous fluctuation (fractional amplitude of low-frequency fluctuation: fALFF) in the precuneus is negatively associated with subjective happiness. However, little is known about the neural electrical...
Human Brain Mapping
April 1, 2025
Clayton R. Coleman, Kenneth Shinozuka, Robert Tromm et al.
4 citations
Lysergic acid diethylamide (LSD) is a classic serotonergic psychedelic that induces a profoundly altered conscious state. In conjunction with psychological support, it is currently being explored as a treatment for generalized anxiety disorder and depression. The dorsolateral prefrontal cortex (DLPFC) is a brain region that is known to be involved in mood regulation and disorders; hypofunction...
Human Brain Mapping
February 15, 2025
Harrison Watters, Aleah Davis, Abia Fazili et al.
1 citation
Early efforts to understand the human cerebral cortex focused on localization of function, assigning functional roles to specific brain regions. More recent evidence depicts the cortex as a dynamic system, organized into flexible networks with patterns of spatiotemporal activity corresponding to attentional demands. In functional MRI (fMRI), dynamic analysis of such spatiotemporal patterns is...
Human Brain Mapping
2025
Isaac N Treves, Aaron Kucyi, Madelynn Park et al.
8 citations
Trait mindfulness refers to one's disposition or tendency to pay attention to their experiences in the present moment, in a non-judgmental and accepting way. Trait mindfulness has been robustly associated with positive mental health outcomes, but its neural underpinnings are poorly understood. Prior resting-state fMRI studies have associated trait mindfulness with within- and between-network...
Human Brain Mapping
August 1, 2024
Mikki Schantell, Jason A John, Anna T Coutant et al.
Regular cannabis use is associated with cortex-wide changes in spontaneous and oscillatory activity, although the functional significance of such changes remains unclear. We hypothesized that regular cannabis use would suppress spontaneous gamma activity in regions serving cognitive control and scale with task performance. Participants (34 cannabis users, 33 nonusers) underwent an interview...
Human Brain Mapping
May 1, 2024
Saampras Ganesan, Winson F.z. Yang, Avijit Chowdhury et al.
23 citations
Advanced meditation such as jhana meditation can produce various altered states of consciousness (jhanas) and cultivate rewarding psychological qualities including joy, peace, compassion, and attentional stability. Mapping the neurobiological substrates of jhana meditation can inform the development and application of advanced meditation to enhance well-being. Only two prior studies have...
Human Brain Mapping
February 1, 2023
Siyang Li, Yali Chen, Peng Ren et al.
Despite that leading theories of consciousness make diverging predictions for where and how neural activity gives rise to subjective experience, they all seem to partially agree that the neural correlates of consciousness (NCC) require globally integrated brain activity across a network of functionally specialized modules. However, it is not clear yet whether such functional configurations...
Human Brain Mapping
January 30, 2023
Brandon Taraku, Roger P Woods, Michael Boucher et al.
23 citations
Ketamine produces fast‐acting antidepressant effects in treatment resistant depression (TRD). Though prior studies report ketamine‐related changes in brain activity in TRD, understanding of ketamine's effect on white matter (WM) microstructure remains limited. We thus sought to examine WM neuroplasticity and associated clinical improvements following serial ketamine infusion (SKI) in TRD. TRD...
Human Brain Mapping
July 29, 2022
Hang Zhang, Shiyou Yang, Yang Qiao et al.
27 citations
The low-frequency (<0.1 Hz) fluctuation in sustained attention attracts enormous interest in cognitive neuroscience and clinical research since it always leads to cognitive and behavioral lapses. What is the source of the spontaneous fluctuation in sustained attention in neural activity, and how does the neural fluctuation relate to behavioral fluctuation? Here, we address these questions by...
Human Brain Mapping
April 9, 2021
Obada Al Zoubi, Masaya Misaki, Jerzy Bodurka et al.
39 citations
Abstract Floatation‐Reduced Environmental Stimulation Therapy (REST) is a procedure that reduces stimulation of the human nervous system by minimizing sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational, and proprioceptive channels, in addition to minimizing musculoskeletal movement and speech. Initial research has found that Floatation‐REST...
Human Brain Mapping
March 19, 2021
Andrea I. Luppi, Daniel Golkowski, Andreas Ranft et al.
72 citations
Abstract The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional...
Human Brain Mapping
August 21, 2020
Lukasz Smigielski, Michael Kometer, Milan Scheidegger et al.
42 citations
Abstract The concept of self and self‐referential processing has a growing explanatory value in psychiatry and neuroscience, referring to the cognitive organization and perceptual differentiation of self‐stimuli in health and disease. Conditions in which selfhood loses its natural coherence offer a unique opportunity for elucidating the mechanisms underlying self‐disturbances. We assessed the...
Human Brain Mapping
July 22, 2020
Ivar R. Kolvoort, Soren Wainio-Theberge, Annemarie Wolff et al.
92 citations
The self is a multifaceted phenomenon that integrates information and experience across multiple time scales. How temporal integration on the psychological level of the self is related to temporal integration on the neuronal level remains unclear. To investigate temporal integration on the psychological level, we modified a well-established self-matching paradigm by inserting temporal delays....
Human Brain Mapping
June 5, 2020
Elvis Dohmatob, G. Dumas, D. Bzdok
The default mode network (DMN) is believed to subserve the baseline mental activity in humans. Its higher energy consumption compared to other brain networks and its intimate coupling with conscious awareness are both pointing to an unknown overarching function. Many research streams speak in favor of an evolutionarily adaptive role in envisioning experience to anticipate the future. In the...
Human Brain Mapping
May 1, 2020
Joana R Loureiro, Amber M Leaver, Megha M Vasavada et al.
65 citations
Electroconvulsive therapy (ECT) and ketamine treatment both induce rapidly acting antidepressant effects in patients with major depressive disorder unresponsive to standard treatments, yet their specific impact on emotion processing is unknown. Here, we examined the neural underpinnings of emotion processing within and across patients (N = 44) receiving either ECT (N = 17, mean age: 36.8, 11.0...
Human Brain Mapping
December 6, 2019
Anna Forsyth, Rebecca McMillan, Doug Campbell et al.
19 citations
The pharmacological modulation of functional connectivity in the brain may underlie therapeutic efficacy for several neurological and psychiatric disorders. Functional magnetic resonance imaging (fMRI) provides a noninvasive method of assessing this modulation, however, the indirect nature of the blood-oxygen level dependent signal restricts the discrimination of neural from physiological...
Human Brain Mapping
October 21, 2019
Bhim M. Adhikari, Juergen Dukart, Joerg F. Hipp et al.
24 citations
Abstract Subanesthetic administration of ketamine is a pharmacological model to elicit positive and negative symptoms of psychosis in healthy volunteers. We used resting‐state pharmacological functional MRI (rsPhfMRI) to identify cerebral networks affected by ketamine and compared them to the functional connectivity (FC) in schizophrenia. Ketamine can produce sedation and we contrasted its...
Human Brain Mapping
September 18, 2019
Norman Zacharias, Francesco Musso, Felix Müller et al.
70 citations
In resting-state functional connectivity experiments, a steady state (of consciousness) is commonly supposed. However, recent research has shown that the resting state is a rather dynamic than a steady state. In particular, changes of vigilance appear to play a prominent role. Accordingly, it is critical to assess the state of vigilance when conducting pharmacodynamic studies with resting-state...
Human Brain Mapping
August 1, 2019
Yi-Chia Kung, Chia-Wei Li, Shuo Chen et al.
Nonrapid eye movement (NREM) sleep is associated with fading consciousness in humans. Recent neuroimaging studies have demonstrated the spatiotemporal alterations of the brain functional connectivity (FC) in NREM sleep, suggesting the changes of information integration in the sleeping brain. However, the common stationarity assumption in FC does not satisfactorily explain the dynamic process of...
Human Brain Mapping
May 7, 2019
Michiel van Elk, M. Andrea Arciniegas Gomez, Wietske van der Zwaag et al.
122 citations
Abstract In the present fMRI study, we aimed to obtain insight into the key brain networks involved in the experience of awe—a complex emotion that is typically elicited by perceptually vast stimuli. Participants were presented with awe‐eliciting, positive and neutral videos, while they were instructed to get fully absorbed in the scenery or to count the number of perspective changes. By using...
Human Brain Mapping
March 9, 2019
Anthony P Zanesco, Alea C. Skwara, Brandon G King et al.
Meditation practice is believed to foster states of mindful awareness and mental quiescence in everyday life. If so, then the cultivation of these qualities with training ought to leave its imprint on the activity of intrinsic functional brain networks. In an intensive longitudinal study, we investigated associations between meditation practitioners' experiences of felt mindful awareness and...
Human Brain Mapping
January 11, 2019
Dea Siggaard Stenbæk, Sara Kristiansen, Daniel Burmester et al.
11 citations
Abstract Recent research found lasting increases in personality trait Openness in healthy individuals and patients after administration of the serotonin 2A receptor (5‐HT 2A R) agonist psilocybin. However, no studies have investigated whether 5‐HT 2A R availability as imaged using positron emission tomography (PET) is associated with this trait. In 159 healthy individuals (53 females), the...