Page 2 of 8: studies 21 to 40 of 148, newest first. Back to the default mode network overview
bioRxiv August 19, 2026 preprint
Differential upregulation of metabolic demands and functional integration of the default mode network during stress
Asploro Journal of Biomedical and Clinical Case Reports August 18, 2026 Hiroshi Bando, Akiyo Yoshioka, Yu Nishikiori et al.
The default mode network (DMN) plays a crucial role in sensory perception. The primary roles of the DMN include preparing for crises, predicting future events, and organizing information and memories. It comprises brain regions such as the medial prefrontal cortex, posterior cingulate cortex, precuneus, and inferior parietal lobule. For the five senses, including visual, auditory, olfactory,...
Scientific Reports August 15, 2026 Morio Aki, Naoya Oishi, Sayaka Yoshimura et al.
Increasing multiculturalism and globalization have increased the discrepancies between socially-shared norms and personal values. This study examined whether the association between Cultural Estrangement (CE) and resting-state functional connectivity (FC) of the default mode network (DMN) is moderated by self-esteem (SE). In total, 170 healthy Japanese adults (20–70 years) were recruited, 70 of...
PsyArXiv August 8, 2026 preprint
Oscillation Dynamics and Default Mode Network Coupling: A Framework for Linguistic Semantic Diversity
Zenodo (CERN European Organization for Nuclear Research) August 7, 2026 Parviz Khataee preprint
The Default Mode Network (DMN) has been characterized since its formal description in 2001 as a resting-state network subserving autobiographical memory, social cognition, and prospective thinking. This paper challenges the foundational interpretive assumption of that characterization: that adult human DMN activity constitutes a normal or optimal cognitive baseline. We propose that the DMN, as...
Research Square August 7, 2026 preprint
Default Mode Network Connectivity Is Associated with Capture by a Distractor Dimension Carrying Learned Spatial Regularity
Brain Imaging and Behavior August 4, 2026
Effects of aging on the mechanisms of dynamic integration between the default mode network and other brain networks: evidence based on fMRI data with natural stimulation.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging August 2026 Sophia H. Blyth, Lauren D Hill, Anna Huang et al.
Adolescent substance use is associated with increased risk of suicide, overdose, and executive dysfunction. Alcohol and marijuana are the two most-used substances among young people. Substance use is associated with dysfunctional resting-state network connectivity between the default mode network (DMN), executive control network (ECN), and salience network (SN) and executive dysfunction. There...
Sleep August 1, 2026
The paradox of right dorsolateral prefrontal cortex targeting: why did low-frequency repetitive transcranial magnetic stimulation modulate default mode network but not frontoparietal network BOLD-CSF coupling in chronic insomnia?
Frontiers in Psychology July 29, 2026
From rest to meaning: default mode network neuroscience as a design constraint for early childhood education.
Progress in Neurobiology July 24, 2026 Oscar Woolnough, Elliot Murphy, Stanislas Dehaene et al.
As you read this sentence, you integrate meanings of individual words into complex, higher-order representations. In addition to the core language network (LN), this dynamic process recruits other domain-general networks such as the default mode network (DMN), with which it partially overlaps anatomically but segregates from functionally. To evaluate interactions between LN and DMN, we...
medRxiv July 22, 2026 Kenneth Shinozuka, Clayton Olash, Tracy Han et al. preprint
Preliminary evidence suggests that the combination of magnesium and ibogaine, an atypical psychedelic, may be a promising treatment for post-traumatic stress disorder (PTSD), opioid use disorder, and traumatic brain injury (TBI). The "mystical" experience elicited by ibogaine, which is characterized by feelings of awe, selflessness, and transcendence, is correlated with improvements in PTSD...
Alzheimer's Research & Therapy July 21, 2026 Sonia Bonnì, Romina Esposito, Lucia Mencarelli et al.
Patients with Alzheimer's disease (AD) exhibit early alterations in the Default Mode Network (DMN), a key brain network involved in episodic memory where the precuneus plays a central role. Precision-targeted, non-invasive brain stimulation represents a promising strategy to improve cognitive function in individuals with dementia. The DMN can be modulated through personalized non-invasive...
The Journal of Headache and Pain July 17, 2026 Siyuan Xie, Chenghui Pi, Kang Jin et al.
BACKGROUND: Migraine is highly heterogeneous, and patients exhibit substantial variability in their responses to preventive treatment. The dose-escalation strategy of topiramate further complicates early evaluation of therapeutic efficacy. Identifying neurobiological markers that can predict treatment response is therefore essential for individualized therapy. In this study, we constructed...
PsyArXiv Preprints July 16, 2026 preprint
This paper proposes a theoretical framework for interpreting immersive neurogastronomic experiences as a form of ambient cognitive modulation. The framework originates in the direct, informal observation of approximately 6,000 guests conducted by the first author over more than six years of operation at Sensorium — an eleven-seat neurogastronomic restaurant with a controlled multisensory...
medRxiv July 14, 2026 Kristian Stefanov, Joel T. Parkinson, Flavia Sunzini et al. preprint
Abstract Nociplastic pain represents a major burden across immune-mediated inflammatory diseases (IMIDs). It is hypothesised, but not yet demonstrated, that peripheral inflammation promotes nociplastic pain by bottom-up sensitisation of the central nervous system (CNS). In rheumatoid arthritis (RA), a prototypic IMID, we used ultra–high field (7T) brain resting-state functional MRI to evaluate...
bioRxiv (Cold Spring Harbor Laboratory) July 10, 2026 Joseph Giorgio, Thomas Morin, Hsiang-Yu Chen et al. preprint
Throughout the preclinical phase of Alzheimer's disease (AD) β-amyloid (Aβ) accumulates preferentially within the default mode network (DMN), yet the functional and behavioural consequences of this pathological burden remain poorly understood. Using task-based fMRI combined with Aβ, tau, and dopamine PET in cognitively normal older adults, we show that Aβ burden impairs learning independent of...
medRxiv July 10, 2026 Lada Kohoutová, Jevita Potheegadoo, Léa F Duong Phan Thanh et al. preprint
Background: Hallucinations, ranging from minor (MH) to structured, are a common non-motor symptom in Parkinson's disease (PD). Structured hallucinations have been associated with altered functional connectivity (FC) between dorsal/ventral attention (DAN, VAN) and default mode (DMN) networks. As structured hallucinations are linked to rapid cognitive decline and MH are often viewed as their...
Research Square July 7, 2026 Ioanna Spanou, Efstratios Karavasilis, Foteini Christidi et al. preprint
Abstract Background Migraine patients are prone to nocebo responses, that hinder treatment adherence. Identifying neurobiological markers of nocebo proneness could help predict and mitigate these adverse effects. Methods This prospective three-arm randomized explorative trial examined default mode network (DMN) connectivity changes during the interictal state and an anxiety-induced nocebo...
Communications Biology July 3, 2026 Fengkai He, Xiaojun Xu, Y Y Zhu et al.
Depression involves dysregulation across distributed cortico-limbic circuits, and ketamine is notable for its rapid antidepressant effects. Although depression and ketamine treatment have been linked to altered brain network topology, how within-frequency and cross-frequency coupling are jointly reorganized at the brain-wide level remains unclear. Here, we developed a frequency-varying...