The paradox of right dorsolateral prefrontal cortex targeting: why did low-frequency repetitive transcranial magnetic stimulation modulate default mode network but not frontoparietal network BOLD-CSF coupling in chronic insomnia?
Sleep plays an important role in affective processing and affect regulation during wakefulness. Dreaming-the subjective experiences occurring during sleep-has been suggested to reflect, or even contribute to, waking affect regulation. However, the role of dream affect in waking affect regulation has rarely been studied directly. Here, we investigated how dream affect relates to waking affect...
Julia Maruani, Pierre A Geoffroy; Nightmare-Focused Interventions and Suicide Prevention: Clarifying the Role of Imagery Rehearsal Therapy and Prazosin, Sl
Abstract Introduction Psychedelic use and interest in its therapeutic potential are rapidly increasing; yet its relationship with insomnia remains poorly understood. This study aims to estimate differences in insomnia severity by type of psychedelic consumed among a cohort of 18-to-35-year olds. Methods Data are from the Herbal Heart Study - Sleep Ancillary (N=100) cannabis consumers....
Abstract Introduction Targeted Dream Incubation (TDI) is the process of giving an individual auditory cues (i.e., “think of a tree”) while they are falling asleep, with the goal of shaping dream content (into something such as a tree). Recent research has demonstrated TDI may be able to increase dream self-efficacy (DSE) and influence other mental health outcomes. Thus, our study explored how...
Abstract Introduction Exploding head syndrome (EHS) is characterized by the perception of a sudden loud noise or explosion in the head that occurs as the patient is falling asleep or waking up, typically associated with fear. The sensation is painless, lasts a few seconds, and may be associated with a flash of light or myoclonic jerk. Report of case(s) A 63-year-old-man with diabetes and...
SleepMay 1, 2026Holland Doise, A. Gonzalez Quesada, Garrett Baber et al.
Abstract Introduction Nightmares are associated with more severe posttraumatic stress disorder (PTSD). The advent of large language models (LLM) offers unique advantages to efficiently code affective dream content over human methods, which can be resource intensive and prone to error. This study tested whether dream affect (DA), measured via self-report, human-rated narrative coding, and LLM...
Nightmares are repeated and lengthy dreams, extremely dysphoric, with clear memory, typically involving life-threatening threats to safety or physical integrity. These nightmares lead to significant distress upon awakening and may substantially impact daytime functioning. Both the experience of these dreams and the sleep disruption produced by the ensuing awakening cause significant impairment...
Reactivation of waking neuronal activity during sleep holds a functional role in memory consolidation. Reprocessing of daytime memory in dreams might aid later memory performance in a similar way. Numerous findings hint at a link between dreaming and sleep-dependent memory processing; however, studies investigating day-residue incorporation in dreaming led to mixed results so far. In this...
The preoptic area of the hypothalamus is key for the control of sleep onset and sleep homeostasis. Although traditionally considered exclusively somnogenic, recent studies identified a group of preoptic glutamatergic neurons that promote wakefulness. Specifically, our previous investigations demonstrated that chemogenetic stimulation of glutamatergic neurons within the medial-lateral preoptic...
SleepMay 19, 2025Emily Feldman, Rebecca Essien, Danya Husein et al.
Abstract Introduction Dream recall frequency (DRF), or how often individuals remember and report dreams, is influenced by factors such as family dynamics, mental health, and cultural norms. Women tend to report higher DRF and greater distress from nightmares, while individuals with psychiatric conditions often exhibit reduced DRF. This study examined the relative contributions of childhood...
SleepMay 19, 2025Otis Eads, John Richmond Sy, Ruth Brombach et al.
Abstract Introduction Lucid Dreaming, defined by a preserved sense of insight, thought, and control while dreaming, has been previously linked to internal locus of control, resilience and problem-solving. Lucid Dreaming may be important for individuals to exert a sense of agency in both dreams and daily life. This study therefore investigates how locus of control relates to lucid dreaming...
Abstract Introduction Dream reports provide unique insights into emotional processing during sleep. While self-reports are the gold standard for assessing dream affect, natural language processing (NLP) tools like ChatGPT may offer scalable alternatives. This study evaluated ChatGPT’s ability to estimate positive and negative affect from dream reports, comparing its performance against...
Abstract Introduction Recent studies and anecdotal reports suggest that sleep-onset hypnagogic dreams can contain creative insights, in some cases leading to Nobel prizes. While such reports are rare, targeted dream incubation (TDI) can induce dreams on pre-selected topics, such as “a tree,” in 70% of dream reports collected shortly after sleep onset, as well as a subsequent increase in...
Abstract Introduction Targeted Dream Incubation (TDI) is the process of utilizing verbal cues (such as, “while you try to fall asleep, try and think of a tree”) during pre-sleep stages in order to directly shape dream content. Preliminary results have demonstrated that TDI may be able to increase dreaming self-efficacy (DSE). Our study aimed to replicate and extend initial findings by examining...
Abstract Introduction Research on psychedelic use and sleep satisfaction remains unclear despite increased use. This study examines the psychedelic use and sleep satisfaction among 18-to-35-year-olds enrolled in the Herbal Heart Study. Methods The exposure variables were lifetime self-reported use of any psychedelic (LSD, psilocybin, peyote, mescaline, ayahuasca/DMT) and psilocybin-alone. Sleep...
SleepMay 1, 2025Michael J. Thorpy, Jennifer M Mundt, Sally Ibrahim et al.
Abstract Introduction Limited information is available to quantify hypnagogic/hypnopompic hallucination (HH) events people with narcolepsy (PWN) may experience. This post hoc analysis from the phase 3 REST-ON trial evaluated individual HH types. Methods REST-ON (NCT02720744) participants (age ≥16 years) with narcolepsy were randomized 1:1 to once-nightly sodium oxybate (ON-SXB) (week 1, 4.5 g;...
SleepMay 1, 2025April Roper, Chase A. Stratton, Janeese A. Brownlow
Abstract Introduction Approximately 12% of U.S. adults report having used any type of psychedelic at some point in their lives, making it one of the most widely used recreational drugs. There exists a need for a better understanding of the consequences of use on objective sleep habits. Research on psychedelics effects on sleep indicate increased sleep duration, increased REM latency, and...
SleepMay 1, 2025Serge Onyper, Joseph Mocerine, G. Cote et al.
Breathwork techniques such as box breathing and paced breathing have been gaining popularity in clinical mental health settings as means to manage stress and enhance well-being. This study explored the impact of a novel controlled breathwork method, cyclic breathing, on sleep in college students. Cyclic breathing involves a double inhale (the first inhale being longer than the second) followed...
SleepMay 1, 2025Mika Hirata, Heba A Afaneh, Ishana Kapoor et al.
Perinatal women are highly vulnerable to insomnia and depression. High cognitive arousal (e.g., worry, rumination) at night is a key risk factor for developing insomnia and depression during this period. However, mindfulness skills have been proposed to reduce risk for negative health outcomes by protecting individuals against the harmful effects of cognitive arousal. This prospective study...
Many studies involving the relationship between personality and nightmare frequency (NF), common in cross-sectional data, have only looked at neuroticism in isolation, assumed a linear relationship, or did not include nightmare disorder index (NDI) to determine if personality traits might predict NDI over NF. While neuroticism is the personality trait most commonly associated with nightmares,...
There is currently no consensus on the definition of nightmares. Most participants define nightmares as “bad dreams” with intense, distressing emotions. Per the DSM-5, nightmares are distressing dreams, but to be diagnosed with nightmare disorder, the dreams must awaken the dreamer. Surprisingly, research has not evaluated the characteristics dreamers use to categorize their nightmares....
Nightmare disorder (NDO) is a significant but often under-recognized condition, especially within the military population. We previously reported that 31.2% of patients referred to our military sleep disorders center have NDO, yet only 3.9% were referred for NDO. Despite the general population’s NDO prevalence (2-8%), our center had no referrals for NDO from June 1 to August 31, 2024. This...
Nightmare Disorder (NDO) is estimated to impact at least 4% of the US adult population yet is reported to be much higher among service members (SMs). Our Center has previously reported 31.2% of referred SMs had probable NDO based on screening measures, yet only 3.9% reported nightmares as a reason for evaluation. No quality measures report on the rate of confirmed diagnosis, and more...