76 papers in the library · 23 citations · publishing 2018-2026
bioRxiv September 3, 2026 preprint
EEG Oscillations in Guided Mindfulness versus Mind-Wandering in Young Adults: Effects of Auditory Task Instruction and Naturalistic Video
bioRxiv August 20, 2026 Ilknur Kayikcioglu Bozkir, Ryan Lashin, Tiecheng Liu et al. preprint
Psilocybin is a psychedelic which has been shown to induce neural plasticity through activation of intracellular serotonergic 5-HT2A receptors. It also produces brain-wide changes in structural and functional connectivity and holds promise as a therapeutic compound for treating anxiety and depression. Despite links between psilocybin-induced plasticity, the psychedelic experience, and reduction...
bioRxiv August 19, 2026 D. Momi, Y. Nahas, D. Wyrick et al. preprint
Psilocybin produces rapid and lasting therapeutic effects, yet how 5-HT2A receptor activation reshapes brain-wide circuit dynamics during acute drug administration remains poorly understood. Using simultaneous multi-region Neuropixels recordings of 46,360 single units from 35 mice, together with scalp electroencephalography (EEG), pupillometry, and locomotion monitoring, we provide a...
bioRxiv August 19, 2026 preprint
Differential upregulation of metabolic demands and functional integration of the default mode network during stress
bioRxiv August 18, 2026 preprint
Tuning in together: LSD enhances inter-brain synchrony and felt connectedness in romantic couples
bioRxiv August 18, 2026 preprint
Brain dynamics exhibit scale-dependent reversibility during consciousness transitions
bioRxiv August 12, 2026 preprint
Near-critical brain dynamics track effortlessness during meditation
bioRxiv August 12, 2026 preprint
Investigating the Effects of Psilocybin on Cognitive Flexibility in Touchscreen and Naturalistic Variations of the Probabilistic Reversal Learning Task
bioRxiv August 6, 2026 Mizuki Yamamoto, Hiroto Inoue, Kazuko Hayashi et al. preprint
Background and Purpose Serotonergic psychedelics affect behavior and physiology, but the relationships among these effects remain poorly understood. In rodents, the head-twitch response is used as a measure of psychedelic-like activity, yet it does not capture changes in physiological state or the performance of learned behaviors. Here, we investigated the acute effects of the 5-HT2A receptor...
bioRxiv August 5, 2026 A. Callara, Francesco Bossi, Jampa Soepa et al. preprint
Seven EEG recordings over thirteen months revealed highly stereotyped transitions between distinct brain dynamics in an advanced meditator, providing a rare experimental window onto large-scale brain-state dynamics. We report an intensive longitudinal EEG case study of an experienced Tibetan tantric practitioner recorded across seven different measurement sessions, including concentrative and...
bioRxiv July 23, 2026 W. J. Tyler, E. Sellers, M. McDonnell preprint
Repeated low-dose psilocybin is being developed as a scalable outpatient treatment for mood and anxiety disorders, but chronic exposure raises concern because psilocin binds the cardiac serotonin 5-HT2B receptor, whose sustained agonism causes drug-induced valvular heart disease (VHD). We evaluated this risk using an exposure–response model that incorporates functional efficacy and exposure...
bioRxiv July 22, 2026 preprint
The “dark magic mushroom” co-produces amatoxins and psilocybin
bioRxiv July 9, 2026 Christine Liu, Ellie M. Ho, Alexander S. Enos et al.
Psychedelic drugs show remarkable potential for treating psychiatric disorders, but the mechanisms underlying their therapeutic effects remain relatively unknown. Here, we demonstrate that psilocybin can powerfully ameliorate deficits in cognitive flexibility, but this effect depends on the specific circuit-level cause of those deficits. Using optogenetic models of cognitive inflexibility in...
bioRxiv July 1, 2026 Alena Lemeshova, Feysal Abdirahaman, Haney Haidari et al.
Acute ketamine treatment produces long-term anxiolytic effects despite increasing oxidative stress in female Wistar Kyoto rats
bioRxiv June 29, 2026
Partitioning away consciousness: an equal and cross-frequency connectivity analysis from the integration-segregation perspective
bioRxiv June 3, 2026 Shuo Yang, Ling-Jun Wang, Yunxiang Sun et al.
Abstract A deeper understanding of the targets and mechanisms of fast-acting antidepressants, exemplified by ketamine, remains indispensable for better therapeutic strategies and understanding depression. Beyond the canonical neuron-centric NMDAR inhibition hypothesis, brain opioid system and glia-mediated processes are increasingly implicated in ketamine’s antidepressant efficacy, yet their...
bioRxiv June 3, 2026 Camilo Espinosa-Curilem, L. Uhrig, Jordie Tasserie et al. preprint
Understanding how consciousness depends on large-scale brain interactions is key for both the neuroscience of consciousness and clinical translation. However, it requires moving beyond classical pairwise descriptions of functional connectivity, which cannot capture the collective dependencies emerging across multiple brain regions. Here, we use multivariate information theory measures to...
bioRxiv June 3, 2026 Yanxia Liang, Lingjun Wang, Yajie Li et al. preprint
Ketamine produces rapid antidepressant effects but is constrained by psychotomimetic properties and abuse potential. The ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) shows antidepressant-like efficacy without N-methyl-D-aspartate receptor (NMDAR) blockade, yet its upstream targets remain unclear. Here we show that HNK potentiates hippocampal excitatory transmission and reverses...
bioRxiv May 29, 2026 Aurora Savino, Carla Liaci, Ilaria Bertani et al.
Summary Psychedelic compounds such as lysergic acid diethylamide (LSD) are increasingly studied for their neuroplastic effects and potential relevance to brain aging and neurodegeneration. However, the molecular mechanisms linking psychedelic-induced plasticity to age-associated cognitive decline remain unclear. Brain aging and dementia are characterized by coordinated transcriptional programs...
bioRxiv May 18, 2026 Kyna Conn, Ngok Wong, Serenay Sunnetci et al.
Abstract Psilocybin has emerged as a promising therapeutic agent for psychiatric disorders characterised by cognitive rigidity and disrupted reward processing, including anorexia nervosa. While its pro-cognitive effects have been mechanistically probed almost exclusively through serotonin receptor subtype antagonism, the downstream contributions of dopaminergic systems to these outcomes remain...
bioRxiv May 6, 2026
Remembered event features shape default mode network engagement during emotional memory recall
bioRxiv May 4, 2026 Tomás Ariel D’amelio, Tomás Gil Garbagnoli, Jerónimo Rodríguez Cuello et al.
ABSTRACT Serotonergic psychedelics induce altered states of consciousness characterised by profound changes in emotional experience. Although psychedelics modulate autonomic arousal, sympathetic engagement during their affective effects remains poorly characterised. We recorded cardiac, electrodermal, and respiratory activity in 19 participants following inhalation of 20 or 40 mg of freebase...
bioRxiv April 27, 2026
Default Mode Network Connectivity Is Associated with Capture by Distractors Assigned to Learned Spatial Regularities
bioRxiv April 23, 2026 S. Kajimura, K. Okano, Senkei Ueno et al. preprint
Dissociative identity disorder (DID) remains debated because identity-state phenomena are privately experienced and may be attributed to suggestion, simulation or role enactment. Most neuroimaging studies rely on symptom provocation or traumatic recall, which complicates interpretation and is poorly suited to co-conscious presentations where simultaneous awareness should make state differences...
bioRxiv April 22, 2026
Abstract Conscious experience is associated with both sufficient cerebral metabolic support and preserved large-scale neural integration, yet these two constraints have largely been studied in isolation. Whether consciousness requires their joint satisfaction — and whether either alone is sufficient — remains an open question. Here, we test the prediction that conscious states occupy a joint...