Mitochondrial fragmentation, which is closely linked to mitochondrial dysfunction, has emerged as a critical treatment target for cervical cancer. Ketamine, a well-known anesthetic, has shown potential in cancer therapy by inducing cytotoxicity, impairing mitochondrial function, and promoting apoptosis in tumor cells. Notably, the regulatory role of ketamine in mitochondrial network dynamics...
Abstract Psilocybin (4‐phosphoryloxy‐ N , N ‐dimethyltryptamine, 1 ) is the main indolethyl‐amine natural product of psychotropic (so‐called “magic”) mushrooms. The majority of 1 ‐producing species belongs to the eponymous genus Psilocybe , for which the biosynthetic events, beginning from l ‐tryptophan ( 2 ), and the involved enzymes have thoroughly been characterized. Some Inocybe (fiber cap)...
bioRxivSeptember 19, 2025Hengda He, B. G. Yazdi, Amir Sedaghat et al.
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While the hemodynamic response function (HRF) of the positive blood oxygenated level dependent (BOLD) signal is well characterized in the functional magnetic resonance imaging (fMRI) field, studies investigating the shape and properties of the negative BOLD HRF, often observed in the default mode network (DMN) regions, are rare. In this study, we first investigated the linearity of the...
Reactivation of waking neuronal activity during sleep holds a functional role in memory consolidation. Reprocessing of daytime memory in dreams might aid later memory performance in a similar way. Numerous findings hint at a link between dreaming and sleep-dependent memory processing; however, studies investigating day-residue incorporation in dreaming led to mixed results so far. In this...
This work explores the potential of Zen Buddhist practices such as meditation, mind-fulness, and acceptance of life's variability, examining their application in contemporary psychotherapeutic programs like Mindfulness-Based Stress Reduction (MBSR). The study employs a concise theoretical analysis of key Zen concepts, including emptiness (sunyata), satori (enlightenment), enso (circle...
Abstract Mindfulness-based interventions have been shown to be mild to moderately effective at decreasing the stress of parents raising children with behavior difficulties. However, questions surround whether mindfulness practices cause changes in specific mindfulness processes—present-moment awareness and responding with acceptance—and how these changes relate to decreased stress. This...
Delta-9-Tetrahydrocannabivarin (THCV), a naturally occurring cannabinoid and structural analog of THC, exhibits a dual pharmacological profile as a CB1 receptor agonist/antagonist and a partial CB2 agonist. This study evaluated the effects of THCV in a THC discrimination model in rats. Male Sprague-Dawley rats (n = 16, 300–340 g, PND60) were trained under a fixed ratio 20 (FR20) schedule to...
This essay explores how ketamine operates as an anesthetic and as an antidepressant through separate but linked mechanisms. Drug repurposing is the application of a drug for a new medical use different from its original purpose, as indicated by the FDA. By comparison of peer-reviewed research on PubMed, NCBI, and clinical trials of ketamine's pharmacology, we find that the mechanism of its use...
Background: Synthetic cannabinoid receptor agonists (SCRAs, commercially known as "Spice") have become a leading cause of substance-induced psychosis worldwide. These compounds show strong associations not only with acute psychotic episodes but also, in a subset of patients, with persistent or relapsing psychotic disorders, patterns that raise concern about progression to schizophrenia. Yet...
ABSTRACT Background NMDA receptor antagonists, such as ketamine, are widely used to model schizophrenia-related phenotypes in preclinical studies. While zebrafish have emerged as a promising model organism for neuropsychiatric research, few studies have characterized their behavioral responses to repeated ketamine exposure. Methods Three independent experiments were conducted to evaluate the...