Cell Reports
July 25, 2023
Gal Vishne, Edden M Gerber, Robert T. Knight et al.
Instances of sustained stationary sensory input are ubiquitous. However, previous work focused almost exclusively on transient onset responses. This presents a critical challenge for neural theories of consciousness, which should account for the full temporal extent of experience. To address this question, we use intracranial recordings from ten human patients with epilepsy to view diverse...
Tijdschrift voor Geneeskunde
July 24, 2023
E. Geleyn, Kim P. C. Kuypers, Mathieu Seynaeve et al.
Classic psychedelics: safety, side effects and medication interactions Given the growing scientific and social interest in the use of classic psychedelics for psychiatric disorders, physicians are increasingly confronted with patients resorting to these drugs. To this date, treatment with classic psychedelics within a medical framework is non-existent. Patients could seek such a treatment...
Preprints.org
July 21, 2023
Fran Hancock, Fernando E. Rosas, Mengsen Zhang et al.
16 citations
preprint
Healthy brain functioning depends on balancing stable integration between brain areas for effective coordinated functioning, with bursts of desynchronisation to allow subsystems to reconfigure and express functional specialisation. Metastability, a concept originated in statistical physics and dynamical systems theory, has been proposed as a key signature that characterises this balance....
Religions
July 21, 2023
Federico Divino
7 citations
This article investigates the challenge of personal crisis during deep meditation, as observed in an ethnographic inquiry into mindfulness and traditional contemplative practices. The study distinguishes between the “crisis of presence” in contemporary mindfulness practices, and the dissolution of the subject-object distinction in traditional Buddhist meditation. By analyzing Ernesto De...
World drug report
July 20, 2023
4 citations
The therapeutic use of psychedelic substances such as LSD and psilocybin has been researched by psychologists and psychiatrists for a range of psychiatric disorders, including substance use disorders. Most of the early research around the therapeutic use of psychedelics was based on case studies or clinical trials that did not meet the contemporary standards of randomized clinical trials, e.g....
Entropy
July 19, 2023
Andrea Buccellato, Yasir Çatal, Patrizia Silvia Bisiacchi et al.
3 citations
Time delays are a signature of many physical systems, including the brain, and considerably shape their dynamics; moreover, they play a key role in consciousness, as postulated by the temporo-spatial theory of consciousness (TTC). However, they are often not known a priori and need to be estimated from time series. In this study, we propose the use of permutation entropy (PE) to estimate time...
Research Square
July 18, 2023
Sanah Malomile Nkadimeng, L. Hay, Christiaan Ml Steinmann et al.
1 citation
preprint
Abstract Background Psilocybin-containing mushrooms induce antidepressant and momentary increase in blood pressure (BP) with potential risk to users with cardiovascular diseases. Irregularities in nitric oxide (NO) levels play a key role in endothelial dysfunctions leading to increases in BP. Mushrooms species show large variation in potency which may potentially induce different outcomes and...
Pharmaceuticals
July 17, 2023
Glorister A. Altê, Ana Lúcia S Rodrigues
17 citations
Ketamine, a racemic mixture of esketamine (S-ketamine) and arketamine (R-ketamine), has received particular attention for its rapid antidepressant and antisuicidal effects. NMDA receptor inhibition has been indicated as one of the main mechanisms of action of the racemic mixture, but other pharmacological targets have also been proposed. This study aimed to explore the possible multiple targets...
BMC Complementary Medicine and Therapies
July 17, 2023
Jojo Yan Yan Kwok, Man Auyeung, Shirley Yin Yu Pang et al.
6 citations
Between 40 and 50% of patients with Parkinson's disease (PD) experience anxiety and depression, associated with impaired physical function, high care dependency and mortality. Recently, the United States National Institutes of Health has urged the implementation of mindfulness practices in chronic illness care. Most research to date has examined the effects on chronically ill patients of...
European Chemical Bulletin
July 13, 2023
Lalit Singh
preprint
This review article explores the potential of N,N-Dimethyltryptamine (DMT) as an antipsychotic drug, acknowledging its therapeutic potential while addressing the controversies and potential risks associated with its use. DMT has distinctive effects on fast brain plasticity and functions as a serotonin agonist hallucinogen, primarily at the 5-HT2A receptor, immune-modulation, and in influencing...