ABSTRACT The recent review of a new drug application for MDMA‐assisted therapy for posttraumatic stress disorder by the United States' Food and Drug Administration (FDA) highlighted epistemological and methodological challenges for evidence assessments. Similar challenges will also be faced in reviews of other compounds in early‐ and late‐stage development, like psilocybin for depression. The...
This paper examines the theological and existential tensions embedded in “Step 2” of the Alcoholics Anonymous 12- Step program within a clinical framework, particularly exploring the neurobiological, psychological, and spiritual dimensions of recovery from trauma, addiction, and chronic pain. Drawing on a multidisciplinary approach that integrates evidence from addiction medicine, Jungian...
A 14-year-old boy reported perceiving transparent colored light fields surrounding human and animal bodies. With drawings and verbal descriptions, he explained the phenomenon in detail. The left side of the body was covered with a transparent blue, and the right side was covered with transparent red, reaching 0.5–2 cm outside the skin. The blue field was attracted towards the north pole of a...
Purpose: The convergence of ancient metaphysical thought and modern scientific inquiry has increasingly drawn attention to the philosophical parallels between Advaita Vedanta, as expounded in the Upanishads, and modern quantum physics. Both systems, despite their distinct methodologies and epistemological foundations, challenge classical notions of reality, duality, and the role of the observer...
BACKGROUND: Findings from contemporary clinical trials suggest that psychedelics are generally safe and may be effective in the treatment of various psychiatric disorders. However, less is known about the risks associated with psychedelic use outside of medically supervised contexts, particularly in populations that are typically excluded from participation in clinical trials. METHODS:...
This article examines the question of whether living beings possess an innate, unchangeable nature or have the capacity for fundamental transformation a question with profound implications for treating addiction-related physical illness. By integrating diverse perspectives from religious and philosophical traditions, mystical thought, modern neuroscience, genetics, and clinical approaches to...
Abstract Background SAPAP3-knockout (SAPAP3-KO) mice develop excessive self-grooming behavior at 4-6 months of age, serving as a model for obsessive-compulsive disorder (OCD). Given that anxiety often precedes OCD diagnosis in humans, this study investigated whether juvenile SAPAP3-KO mice exhibit anxiety-like behaviors before developing the self-grooming phenotype, and whether such behaviors...
Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects. LSD modulates serotonin (5-HT2A) receptors, which, in turn, influence dysfunctional brain networks involved in emotional processing and cognition. It has also shown promise...
Abstract. Galay KV, Plimaco SMY. 2025. Mycochemical screening, antioxidant, and cytotoxic properties of Panaeolus cyanescens. Nusantara Bioscience 17: 137-154. This study focuses on exploring the subtleties of the hallucinogenic mushroom Panaeolus cyanescens Sacc., known for its psychoactive component psilocybin. The study focuses on exploring the phytochemical, antioxidant, and cytotoxic...
Medicine is taught as a science, but in reality, as with other areas that undergo much public scrutiny, it is often more of an art than a science. Particularly when dealing with controversial areas, physicians often attempt to employ the "standard of care" as a guide to practising medicine, and to protect themselves. However, the standard of care itself is often a reactive and temporary...