Mindfulness-based interventions (MBIs) are widely used to promote psychological and physical health, yet their efficacy among individuals with histories of adverse childhood experiences (ACEs) has been mixed. While most conceptualizations attribute the cultivation of nonjudgmental awareness as a primary mechanism of MBI-related benefits, individuals with stress-regulatory systems that were...
Consciousness in Zen meditation has garnered considerable interest in psychology and neuroscience, particularly in relation to its association with enhanced self-awareness. Zen meditation fosters social harmony by addressing mental and social conflicts, linking individuals to various societal aspects through the practice. This meditation, rooted in Buddhism, aims to perceive thoughts without...
The psychedelic psilocybin has shown therapeutic potential, yet underlying neural mechanisms remain poorly understood. We investigated the impact of psilocin-the active metabolite of psilocybin-on basal activity and reactivity within the paraventricular nucleus of the thalamus (PVT) and PVT projections to central amygdala (CeA) in rats. Psilocin administration increased PVT c-Fos expression and...
To some, purposiveness is the core of the enactive approach. Others, however, view the notion of purposes as a pre-scientific crutch – one that will eventually be replaced by mathematical analyses of the kind of dynamical systems that we are. Yet advances in cognitive neuroscience have not vanquished the problem of purpose, only driven it underground. Rather than explicitly confronting this...
David Cronenberg’s The Fly (1986) is examined as a philosophical allegory that explores key dimensions of corporeality, identity, and the boundaries of the human. The article focuses on the bodily metamorphosis of the protagonist, Seth Brundle, as a result of a technological experiment that leads to his hybridization with an insect. The author considers how bodily transformation challenges the...
Research indicates that first‐episode psychosis (FEP) with cannabis use disorder (CUD) carries a substantial disease burden, but more granular clinical trajectories of cannabis‐related psychoses remain unclear. This study examines the clinical trajectories of first clinically diagnosed FEP&CUD and cannabis‐induced psychosis (CIP) in comparison with FEP without substance use disorder (SUD).
CureusApril 8, 2026Christian David Galindo, Victor Agudelo, Ivan Ramirez Blanco et al.
Trance and possession disorder (TPD) is a complex and culturally influenced condition characterized by alterations in consciousness, identity, and behavior, often posing diagnostic challenges in clinical psychiatry. We report the case of a young woman who presented with a 12-hour history of visual and auditory hallucinations, disorganized speech, and aggressive behavior toward her partner,...
Scientific objectivity is traditionally understood as a regulative ideal achieved through methodological rigor,intersubjective verification, and empirical testing. However, this conception presupposes relatively stable cognitive conditions under which observation and interpretation occur. Drawing on insights from cognitive neuroscience, predictive processing, and contemplative research, this...
The present publication does not introduce a new model; instead, it establishes a conceptual foundation for future research on the potential multiplicity of hypnopompic windows within a single night. Preliminary observations—addressed in a forthcoming publication—suggest that under certain conditions the hypnopompic window may appear twice, each instance associated with a distinct block of...
To the Editor, Autism spectrum disorder (ASD) is a neurodevelopmental state in which there are early emerging problems in social communication along with fixed behavior patterns. Social difficulties in ASD are characterized by difficulty in interpretation of interpersonal signals such as facial expressions, tone of voice, and body language. Individuals with ASD often present with social...