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Journal of Biochemical and Molecular Toxicology

ISSN 1099-0461

2 papers in the library · 2 citations · publishing 2025

Papers

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S100B+ Astrocytes Are Altered in the Mouse Brain Upon Ketamine Challenge: Implications for the Symptoms of Schizophrenia.

Journal of Biochemical and Molecular Toxicology December 1, 2025 Nimmi Varghese, Aadithye Ravikumar Nair, Parayil Sobha Anumol et al.

Schizophrenia is a complex neuropsychiatric disorder characterized by positive, negative and cognitive symptoms. The pathophysiology of schizophrenia is largely unknown, but it is understood that this mental disorder is a manifestation of genetic, environmental and biological factors. Herein, we focus on S100B, a family of calcium binding cytosolic proteins that play a profound role in glial...

Ketamine Induces Mitochondrial Fission and Dysfunction in Cervical Cancer Cells via RhoA‐Dependent DRP‐1 Activation

Journal of Biochemical and Molecular Toxicology September 21, 2025 Yanfang Zhou, Guangming Chen, Ye Zhu 2 citations

Mitochondrial fragmentation, which is closely linked to mitochondrial dysfunction, has emerged as a critical treatment target for cervical cancer. Ketamine, a well-known anesthetic, has shown potential in cancer therapy by inducing cytotoxicity, impairing mitochondrial function, and promoting apoptosis in tumor cells. Notably, the regulatory role of ketamine in mitochondrial network dynamics...