BACKGROUND: Non-suicidal self-injury (NSSI) is highly prevalent among individuals with borderline personality disorder (BPD) and a robust predictor of future suicide attempts and death. Access to comprehensive treatments such as dialectical behaviour therapy remains limited. METHODS: This exploratory study evaluated the feasibility and preliminary outcomes of a brief, group-based...
Abstract Background and aims Ibogaine, one of the oldest psychedelic alkaloids introduced to Western society and medicine, has a largely overlooked history prior to Howard Lotsof's accidental identification of its anti-addictive properties in the 1960s. This manuscript explores some previously hidden aspects of ibogaine, with a focus on the entangled cultural, colonial, and scientific histories...
Chronic ischemic stroke survivors experience cognitive, emotional, and participation-related limitations that affect reintegration into the community and life satisfaction. Mindfulness-Based Stress Reduction (MBSR) and Cognitive Rehabilitation Therapy (CRT) may aid in the recovery process of stroke survivors. These rehabilitation programs may act through different mechanisms. However, little is...
Abstract The notion of qualia is often seen as a suspicious philosophical invention that bears no relevance to the research of psychological and cognitive mechanisms that govern our behavior. The idea of “ineffable” phenomenal qualities has been criticized, inter alia, as unscientific and empirically unsupported. Against that popular conception, it is here argued that some complex human...
This article explores the processes that led to the inclusion of psychedelics under the 1971 Convention on Psychotropic Substances, a cornerstone of international drug control. Drawing on archival records, we analyze the narratives and dynamics that shaped this decision. Despite limited scientific evidence of public health dangers, concerns about psychedelics were amplified by sensationalized...
Neurobiological advances-from Global Neuronal Workspace (GNW) and Integrated Information Theory (IIT) to predictive processing-have transformed how we model conscious access, integration, and inference. These frameworks primarily explain capacities and mechanisms (how information becomes globally available, is integrated, or is prediction-driven), not what is experienced in a situation nor what...
Adolescents experience extensive neurocognitive development, with cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal...
Bipolar disorder (BD) is a prevalent mood disorder that can be associated with serious personal, societal, and economic costs. Growing attention is being paid to the importance of including the experiences of people living with BD in research and healthcare system advancement. However, there is still much to be learned about what people with BD are prioritizing, and where their needs are not...
This chapter explores a simple but provocative idea: What if “information” is not just what we write down about the world but part of the world’s load-bearing architecture? We begin with consciousness as lived fact—how it feels to be aware—and set that alongside scientific accounts, from global workspace theory and integrated information theory to carefully framed quantum proposals. We then...
Schizophrenia is a serious neuropsychiatric disorder marked by oxidative stress, immune system changes, and neurochemical imbalances. Current treatments are constrained by inconsistent effectiveness and side effects. This study evaluates the neuroprotective effects of sabinene, a monoterpene, in a mouse model of ketamine-induced schizophrenia. Male mice received ketamine (20 mg/kg/day, i.p.)...