Smoked cannabis is known to have effects on cognitive function. The use of edibles is on the rise yet there are few studies of the effects of edibles on cognitive function. Further, most studies of cannabis used fixed laboratory doses which may not capture some of the nuances of more naturalistic doses. Delta-9-tetrahydrocannabinol (THC) is the psychoactive component of cannabis yet the...
Cannabis constituents, including Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD), show distinct pharmacological profiles with therapeutic relevance for neurological and psychiatric conditions. THC exerts euphoric effects primarily via CB1 receptor activation, while CBD displays non-euphoric properties affecting various pathways. This study evaluated the effects of THC, CBD, and their...
Polysubstance use of opioids and stimulants is increasingly common among individuals with a substance use disorder, yet most researchers examine these substances in isolation. This gap limits our understanding of the effects of polysubstance use and how these differ from single substance use. Here, we examined the impact of single versus polysubstance exposure of fentanyl and methamphetamine on...
Classical psychedelic drugs show promise as a treatment for major depressive disorder and related psychiatric disorders. This therapeutic efficacy stems from long-lasting psychedelic-induced neuroplasticity onto prefrontal cortical neurons and is thought to require the postsynaptic expression of serotonin 2A receptors (5-HT_2AR). However, other cortical regions such as the granular...
Background: Psychedelic therapies are gaining attention as tools to alleviate anxiety and depression across various clinical populations. However, the mechanisms behind psychedelics' therapeutic efficacy and the potential differences in how patients with certain diagnoses experience their subjective effects remain unknown. One commonly suggested mediator of positive outcomes across psychedelics...
Psychedelics have emerged as potential therapeutics for substance use disorders, yet preclinical data validating their efficacy remain limited. Here, we investigated the effects of a clinically inspired dose-escalation protocol of psilocybin and ibogaine on extinction and cue-induced reinstatement in Wistar male rats following intravenous cocaine self-administration (IVSA). Rats were trained on...
Psychedelic compounds such as LSD and Psilocybin have historically been classified alongside illicit substances and widely regarded with skepticism. However, emerging neuroscientific evidence suggests that certain psychedelics may function as “psychoplastogens”- compounds capable of promoting structural and functional neural plasticity. Recent preclinical and early clinical studies indicate...
Ayurveda describes health as a state of dynamic balance between Sharira(body), Indriya (Sensory and motor systems), Manas (Mind), and Atma (Conscious self), and places strong emphasis on the role of Manas in both the origin and recovery of disease. Classical texts identify Rajas (Hyperarousal) and Tamas (Hypoarousal) as manasika dosha (mental regulatory patterns) and explain Prajnaparadha...
Scientific ReportsFebruary 28, 2026Patryk Główczyński, Paweł Dębski, Karina Badura-Brzoza
Spirituality and religiosity are increasingly examined as factors relevant to mental health, yet less is known about individualized nonreligious forms of spiritual practices. In this cross-sectional study, we investigated associations between spirituality, religious affiliation, non-religious forms of spiritual practices (NFSP) and symptoms of anxiety and depression in 1240 young adults aged...
Death StudiesFebruary 28, 2026Xiuxin Wang, Xiaohan Hu, Mengyao Tian et al.
In contrast to the established link between death anxiety and reduced meaning in life, this study proposes that death reflection is positively related to meaning, and examines its differentiated pathways to the presence of and search for meaning via self-transcendence and authentic-self pursuit. A cross-sectional study with 501 participants assessed the variables. Results indicated that death...