Farmacja PolskaDecember 30, 2025Ewa Niedzielska-Andres, Angelika Ziaja, Stanisław Zielinski et al.
Przedmiot badań: W ostatnich latach obserwuje się rosnące zainteresowanie wykorzystaniem naturalnych halucynogenów w leczeniu zaburzeń psychicznych, uzależnień czy bólu. Substancje takie jak psylocybina, ayahuasca, ibogaina czy meskalina poddawane są ocenie w badaniach klinicznych, które wskazują na ich potencjał terapeutyczny, zwłaszcza w leczeniu depresji lekoopornej, zespołu stresu...
Distinguishing metabolite isomers often relies on comparing relative data, such as relative chromatographic retention times and ion mobility arrival time orders, or relative product ion abundances. These approaches necessitate the need for quality reference data and/or chemical standards. An ideal method for differentiating isomers would leverage one of the absolute physiochemical properties of...
N,N-dimethyltryptamine (DMT) is a fast-acting psychedelic drug that induces a radical reorganization of conscious contents and brain dynamics. However, our understanding of how brain dynamics support psychedelic-induced conscious states remains unclear. We therefore present a repeated-measures dose-dependent study of the subjective and neural dynamics induced through DMT under naturalistic...
Objective: This study aimed to characterize changes in estimated past-year lysergic acid diethylamide (LSD) use among sexual minorities in the United States using nationally representative data and to compare correlates of LSD use between lesbian, gay, and bisexual individuals (LGB) and heterosexual individuals. Method: Using National Survey on Drug Use and Health data on adults from 2015 to...
Major depressive disorder (MDD) is a multifactorial mental health condition involving genetic, environmental, and neurobiological factors. Conventional antidepressants such as fluoxetine, a selective serotonin reuptake inhibitor, require weeks to exert therapeutic effects, whereas ketamine and esketamine act rapidly via glutamatergic modulation. These drugs may also converge on the inhibition...
Pharmacological ResearchDecember 29, 2025Martina Colognesi, Daniela Gabbia, Anna Signor et al.3 citations
The therapeutic potential of low, non-psychedelic doses of psilocybin, a fungal tryptamine alkaloid, was investigated in metabolic disorders including obesity, type 2 diabetes mellitus (T2DM), and liver steatosis. Mice fed a high-fat/high-fructose diet received chronic treatment with psilocybin (0.05 mg/kg) for 12 weeks. Body weight, liver histology, insulin sensitivity, and skeletal muscle...
The revelation thesis, namely the claim that introspection or phenomenal concepts reveal the full essence of conscious states, has recently become a central topic in the philosophy of mind. On the one hand, many argue that the plausibility of anti‐physicalist arguments (such as conceivability arguments) depends on it. On the other hand, the revival of panpsychism has also invoked the revelation...
What happens to a unified conscious field when its physical implementation straddles a black hole event horizon? This paper addresses that question for integration-based theories, including Integrated Information Theory, Global Workspace Theory, and Predictive Processing. These views share a structural commitment: unity requires a single strongly connected component (SCC) in an effective causal...
A ayahuasca é uma bebida psicoativa de origem amazônica, tradicionalmente utilizada por povos indígenas e por religiões de matriz brasileira, cuja composição combina plantas ricas em N,N-dimetiltriptamina (DMT) e alcaloides β-carbolínicos. Nas últimas décadas, observa-se crescente interesse científico acerca de seus potenciais efeitos terapêuticos, especialmente no campo da saúde mental, bem...
Abstract It has been proposed that both conscious and unconscious perception are associated with a feedforward sweep of oscillatory activity in the gamma band (>40 Hz), while conscious perception also requires recurrent feedback via beta band ($\sim$20 Hz) oscillations. To investigate the causal relationship between these oscillations and (un)conscious visual perception, we assessed the effect...