bioRxiv : the preprint server for biology
March 6, 2026
Natasha E Wade, Ryan M Sullivan, Alexander L. Wallace et al.
preprint
Adolescents experience extensive neurocognitive development, with cannabis use potentially impacting developmental trajectories. Here, we comprehensively assess the influence of adolescent cannabis use onset on neurocognitive trajectories and consider how recent delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may influence neurocognition. We use the large, diverse longitudinal...
Frontiers in adolescent medicine
2025
Alexander L. Wallace, Rachel E. Baca, Gianna Andrade et al.
The endocannabinoid (eCB) system is a regulatory mechanism that helps to maintain homeostasis in the brain. Cannabis use and circulating eCB disruptions have been linked with altered memory; however, this work has largely been done in animal models with minimal investigation into these relationships by sex. We aim to investigate how circulating eCB concentrations in cannabis using young adults...
Brain Sciences
February 24, 2022
Julia C. Harris, Alexander L. Wallace, Alicia M. Thomas et al.
Background. Numerous neuropsychological studies have shown that cannabis use during adolescence and young adulthood led to deficits in sustained and selective attention. However, few studies have examined functional connectivity in attentional networks among young cannabis users, nor have characterized relationships with cannabis use patterns following abstinence. Methods. Differences in...
NeuroImage: Clinical
April 8, 2021
Megan M. Ritchay, A. Huggins, Alexander L. Wallace et al.
Highlights • We examined resting state connectivity in the DMN in cannabis users and controls.• Cannabis users displayed abnormal connectivity compared to healthy controls.• Abnormal connectivity in cannabis users related to poorer cognitive performance.• Abnormal brain communication may remain after ≥ 3 weeks of cannabis abstinence.
Journal of the International Neuropsychological Society
April 20, 2020
Alexander L. Wallace, Natasha E Wade, Krista M. Lisdahl
Abstract Objectives: Previous research suggests recovery from cannabis-related deficits in verbal learning and memory functioning after periods of cannabis abstinence in adolescents. Here, we examine how cannabis cessation affects cognitive performance over 2 weeks of monitored abstinence compared to controls in adolescents and young adults. Methods: Seventy-four participants (35 cannabis...
Archives of Clinical Neuropsychology
September 22, 2018
Alexander L. Wallace, Natasha E Wade, Kelah Hatcher et al.
43 citations
OBJECTIVE: Research has demonstrated comorbidity between Attention-Deficit Hyperactivity Disorder (ADHD) and cannabis use, and some have proposed that subclinical ADHD symptoms may explain attentional deficits in cannabis users. Here we investigated whether subclinical ADHD symptoms and cannabis use independently or interactively predict performance on attention tasks in adolescents and young...