PURPOSE/BACKGROUND: Chronic insomnia causes malaise and is associated with depression, irritability, cognitive impairment, impaired alertness, and substance abuse. Individuals with posttraumatic stress disorder (PTSD) often have both inadequate and fragmented sleep, putting them at elevated risk for these consequences. Sleep abnormalities in patients with PTSD include frequent trauma-related...
International altruism is crucial for promoting global stability and peaceful development. Thus, it is vital to identify factors that can enhance international altruism. Building upon the revised small-self hypothesis, we investigated whether dispositional awe affects international altruism, as well as the mediating roles of self-transcendence and identity with all humanity (IWAH), in different...
There is growing interest in novel approaches to treating posttraumatic stress disorder (PTSD), including the use of psychedelic substances combined with psychotherapy, often referred to as psychedelic-assisted therapy, to better meet the needs of patients who do not prefer or respond to traditional evidence-based treatments. Among these treatments, 3,4-methylenedioxymethamphetamine...
Psychedelic compounds such as psilocybin, Lysergic Acid Diethylamide (LSD), N,Ndimethyltryptamine (DMT), and 3,4-methylenedioxymethamphetamine (MDMA) are emerging as novel therapeutics for neuropsychiatric disorders, including depression, Post-Traumatic Stress Disorder (PTSD), and addiction. Acting primarily through serotonin 5-HT2A receptor agonism, they activate intracellular cascades...
Esketamine (ESK), the dextrorotatory enantiomer of ketamine, is an antagonist of the N-methyl-D-aspartic acid (NMDA) receptor. ESK is considered an effective anesthetic because of its ability to mitigate postoperative pain and opioid use. Recently, it has attracted significant research attention for its fast-acting antidepressant effects. Given the advantages of ESK in both perioperative and...
FigshareMarch 11, 2026Jenna Houff, Andrew Williams, Obie Allen et al.
preprint
Clinical trials suggest that a single dose of psilocybin may be an effective treatment for substance use disorders. Choice impulsivity is a value-based decision-making bias that predicts drug-intake escalation and is commonly associated with substance use disorders. The dorsomedial prefrontal cortex regulates choice impulsivity and is enriched with 5-HT2A receptors that mediate effects of...
Given the increasing availability of high-potency Δ9-tetrahydrocannabinol (Δ9-THC) products, understanding potency-related effects of Δ9-THC on driving performance is an important public safety issue. This randomized, double-blind, placebo-controlled, within-subjects trial examined the effects of smoked cannabis with varying Δ9-THC concentrations on simulated driving. Adults aged 19–45 who...
El craving constituye un fenómeno central en los trastornos por uso de sustancias, actuando como predictor de recaída y perpetuando el ciclo adictivo. Las intervenciones basadas en mindfulness han emergido como estrategias prometedoras para su abordaje terapéutico. En este sentido, el objetivo de la presente revisión sistemática fue evaluar la eficacia de las intervenciones basadas en...
Substance-induced psychoses (SIP) may offer a useful vantage point for exploring mechanisms underlying psychotic disorders and for examining the phenomenological specificities of schizophrenia. Clinical observations suggest that a clinically relevant subset of patients does not fully recover after an episode of substance-induced psychosis, raising the hypothesis of more persistent psychotic...
BACKGROUND: Non-suicidal self-injury (NSSI) is highly prevalent among individuals with borderline personality disorder (BPD) and a robust predictor of future suicide attempts and death. Access to comprehensive treatments such as dialectical behaviour therapy remains limited. METHODS: This exploratory study evaluated the feasibility and preliminary outcomes of a brief, group-based...