Introduction: Work-related stress is a common concern in contemporary work environments, affecting employees physical and psychological health. It is essential to identify effective interventions to mitigate stress and its associated health risks. Mindfulness-based interventions (MBIs) have gained attention as promising methods for stress reduction and mental health improvement. This systematic...
Background: Opioid receptors are a commonly used target for treatment of pain conditions. Most opioids used in therapy are linked to adverse effects such as tolerance, dependence, and respiratory depression. Indole alkaloids acting on opioid receptors may provide a novel molecular mechanism to confer analgesic effects. Results: Indole alkaloids such as ibogaine and mitragynine act on μ-opioid...
The rapid expansion of psychedelic research has opened significant pathways of opportunity in treating mental health disorders. Participants in recent clinical trials consistently report mystical-type experiences during dosing sessions, and some scholars posit that such experiences themselves help mediate clinical improvements in depression, PTSD, anxiety, and substance use disorders. These...
To explore the effective bridging paths for consumers' "intention-behavior gap", this study constructs a theoretical model based on Value Theory and the Theory of Planned Behavior, with self-transcendence values as the independent variable, perceived behavioral control as the chain mediating variable, and the degree of intention-behavior alignment as the dependent variable. Four research...
Background: Major depressive disorder (MDD) is a highly prevalent and disabling psychiatric condition associated with substantial clinical, social, and economic burden [1,2]. Despite the availability of conventional antidepressants, their limited effectiveness, delayed onset of action, and high relapse rates have renewed interest in innovative therapeutic approaches [3,4,5]. Psilocybin-assisted...
Abstract In slogan form, the thesis of this chapter is that beliefs are self-verifying fictions: We make them up, but in so doing, they come to exist, and so the fiction of belief is in fact true. This picture of belief emerges from a combination of three independently motivated views: (1) a phenomenal intentionalist picture of intentionality, on which phenomenal consciousness is the basis of...
IMPORTANCE: As psychedelic-assisted therapies gain clinical legitimacy, their cultural portability remains underexamined. While promising results have emerged from trials on existential distress in life-limiting illness, most protocols reflect Euro-American values. The expansion of these therapies calls for a pivot toward cultural humility and renewed attention to what constitutes a "good...
Objectives The .b (“dot be”) mindfulness program aims to reduce both internalizing and externalizing risks and to enhance well-being among adolescents. A UK-based feasibility study (FS) reported significant improvements in depressive symptoms, stress, and well-being, whereas a large-scale randomized controlled trial—the UK-based MYRIAD study (MS) found no improvements and even some negative...
This review provides a systematic critique of the debate between two paradigms in the philosophy of mind—the Naturalist–Externalist Research Program (NERP) and the Phenomenal Intentionality Research Program (PIRP)—with particular focus on Uriah Kriegel’s reconciliation project. Following Kriegel’s view, attention is given to rational agents’ awareness of their mental states—a key issue since...
Psychedelic-assisted therapies (PATs) can produce rapid and sustained antidepressant effects, yet variability in response remains substantial. Identifying predictors and moderators is essential for optimising patient selection, preparation, and delivery. To map and synthesise the evidence on the predictors of antidepressant response to classic/serotonergic psychedelics administered with...