Drawing on the comparative historical analysis of hunter-gatherer and forager lifeways alongside the science and art of tracking among hunter-gatherer communities in southern Africa, this paper examines the phenomenon of interspecies transference, or ontological assimilation of sentience, experienced during the practice of cross-species tracking. This paper aims to demonstrate that...
Abstract Psychedelics profoundly alter conscious experience, yet how they reshape the relationship between brain anatomy and function remains unclear. In particular, it is unknown whether psychedelic states reflect a global disruption of structure–function organization or a frequency– and network-specific reconfiguration of neural dynamics relative to the structural connectome. Here we address...
Abstract Psilocybin, a serotonergic psychedelic, can produce rapid and enduring antidepressant effects in patients with major depressive disorder (MDD)[1, 2], yet the neural mechanisms underlying these effects remain unclear. Negative affective biases are an important neuropsychological mechanism central to the development and perpetuation of MDD[3]. Using a translational rodent model, we...
Background: The Default Mode Network (DMN) is consistently implicated in self-referential thinking and rumination and shows altered functioning in depression and anxiety disorders. The Attention Training Task (ATT), a core technique in metacognitive therapy, aims to reduce internally directed attention by enhancing flexible attentional control. While previous neuroimaging studies have...
Time feels different depending on your mental state. It compresses when you're in the zone, stretches on psychedelics, and disappears completely under anesthesia. These distortions are well documented in neuroscience, but the major theories of consciousness don't generate quantitative predictions about them. This paper presents a formal framework that attempts to. It proposes that consciousness...
Consciousness is expressed across a spectrum of states, from shared sensory reality to deeply individuated, internally oriented experience. This paper develops a hypothesis for how consciousness may operate across this continuum. The central proposal is that beta and alpha oscillations support externally focused, intersubjective awareness through classical neural networks, whereas theta, delta,...
ChemRxivMarch 2, 2026William Charles Hosie, Artem Pyrozhok, Massimo Filgiomeni et al.
preprint
Clinical trials of psychedelics have shown preliminary promise for the treatment of psychiatric conditions such as major depressive disorder, substance use disorder, and treatment resistant depression.The most common psychedelic administration routes explored so far include intravenous injection, heated vapor inhalation, or a simple buffered salt solution administered to the nasal cavity.Given...
Major depressive disorder (MDD) is increasingly viewed as a disorder of impaired neural plasticity, yet the mechanisms underlying diverse antidepressant classes - glutamatergic (e.g., ketamine), monoaminergic (e.g., selective serotonin reuptake inhibitors (SSRIs)), and GABAergic (e.g., neurosteroids) - remain incompletely integrated. The objective of this study was to extend a...
Objective: While data on perceived availability of lysergic acid diethylamide (LSD) [paLSD] are collected annually in the United States, detailed investigations of recent trends in paLSD have not been published. Therefore, we sought to explore this topic. Method: Data were sourced from the 2015–2019 National Survey on Drug Use and Health (NSDUH) administrations. To identify factors associated...
Background: Psilocybin-assisted psychotherapy (PAP) may be an effective intervention for a range of mental disorders. However, there appears to be a relative lack of qualitative evidence to complement emerging quantitative findings. To our knowledge, no reviews have systematically mapped the literature on qualitative studies on PAP for the treatment of mental disorders with the intent to...