An emerging approach called California Sober (CS) has gained attention for promoting abstinence of all intoxicating substances except cannabis and potentially, psychedelics. Cannabis legalization and the expansion of cannabis products have introduced new complexities in addiction recovery, challenging traditional abstinence-based frameworks such as Alcoholics Anonymous (AA), which define...
Background The prevalence of short video addiction is rising among college students, potentially exerting detrimental effects on their physical and mental wellbeing. Medical students, who experience relatively higher levels of academic stress, may be particularly susceptible to the adverse consequence of short video addiction. However, the specific factors influencing this addiction and the...
Summary This case report presents the case of a 25-year-old woman who developed ketamine addiction following a single sub-anaesthetic dose of intranasal ketamine in a pilot study investigating intranasal racemic ketamine for acute suicidality. She had a history of depression, obsessive–compulsive disorder, autism spectrum disorder and anorexia nervosa, and she had sporadically used alcohol and...
JMIR Research ProtocolsMay 1, 2026Megan Kirouac, Daniel S Otero, David I K Moniz-Lewis et al.
Background: Globally, approximately 8.6% of people will meet criteria for alcohol use disorder (AUD) in their lifetimes, with 2.2% meeting criteria for AUD in the past 12 months. In the United States, AUD prevalence is even greater, with 13.9% meeting criteria in the past 12 months. Effective treatments for AUD exist, although most people receive help through mutual support groups (ie,...
Many people use cannabis to self-medicate for pain. Little is known about the impact of pain on tolerance and spontaneous withdrawal to delta-9-tetrahydrocannabinal (THC), the primary psychoactive compound in cannabis. Our previous research with the opioid morphine suggests persistent pain will increase the magnitude and duration of THC withdrawal. Male and female Sprague-Dawley rats were...
A number of proposals across different fields have suggested incorporating "independent" actors into the research process as a way to manage potential bias. For example, in response to allegations of bias in psychedelic science, some have suggested the idea of independent auditors for adverse events, as well as the incorporation of independent researchers into the research teams of psychedelic...
Recent years have witnessed an “interactive turn” in the cognitive sciences, increasingly foregrounding real-time social interaction and organism–environment dynamics. Yet, even the interactive turn often stops short of its own implications, leaving an individual-first explanatory order largely intact. Taking these implications seriously points toward an explanatory reversal: human...
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AddictionApril 30, 2026Ka Tsun Ting, Ivan Chun Him Leung, Dicken Cheong-Chun Chan et al.
Background and aims: Mindfulness-based relapse prevention (MBRP) has been shown to be beneficial to individuals with substance use disorder (SUD) in the West. The current pilot study aimed at testing the feasibility of MBRP in a Chinese population. Design: This pilot study adopted a design of randomized controlled trial comparing MBRP with treatment-as-usual group (TAU). Setting: Participants...
Psychedelic drugs are serotonergic hallucinogens that can be divided into two types: naturally occurring (psilocybin, psilocin, and N,N-dimethyltryptamine) and synthetic (LSD, MDMA, 2,5-dimethoxy-4-iodoamphetamine, and ketamine). Psychedelics generally work on 5-hydroxytryptamine receptors and might be useful in cognitive enhancement, brain connectivity, neuroplasticity, and neuronal...
This study aimed to examine the impact of a mindfulness-based psychoeducation program on university students' levels of mindfulness, digital well-being, and digital addiction. The current study examined the effects of an 8-week mindfulness-based psychoeducation program on university students' mindfulness, digital well-being, and digital addiction levels. The study group consists of 310...
Polysubstance use involving psychostimulants and opioids is increasingly prevalent and associated with elevated overdose risk, relapse vulnerability, and poor treatment outcomes. However, the neurobehavioral consequences of opioid-stimulant use remain poorly understood. We evaluated whether repeated methamphetamine-fentanyl polysubstance treatment disrupts social preference during withdrawal,...
Objectives: The psychometric properties of the Spanish versions of the Quiet Ego Scale (QES), the Nondual Awareness Dimensional Assessment (NADA), and the Ontological Addiction Scale (OAS‑24) were examined. Methods: The analyzed sample was composed of 242 adults from the Spanish general population. Factor structure, internal consistency, and convergent validity were tested, along with...
BMC NursingApril 18, 2026Yanqing Yan, Qiuxian Ye, Taiping Li et al.
BACKGROUND: Internet addiction (IA) has become an increasingly prevalent behavioral health concern among university students, with previous studies reporting substantial levels of problematic internet use among nursing students, including a multicenter study in China that found a prevalence of 23.3%. Because problematic internet use may be associated with poorer quality of life (QL), QL...
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Background Methamphetamine (MA) addiction is a chronic relapsing disorder that impairs physical health, induces mental distress (e.g., anxiety), and triggers abnormal inflammatory and neurotransmitter responses, all contributing to high relapse rates. Mindfulness and yoga interventions may alleviate psychological distress and improve physical well-being in substance users; however, few studies...
Nicotine addiction is a major contributor to preventable morbidity and mortality globally, forming the biological basis of the tobacco pandemic. Despite the availability of nicotine replacement therapies and behavioral interventions, relapse rates remain high due to nicotine’s profound impact on neurochemical reward pathways. To explore and review novel and emerging treatment modalities that...
Abstract Background Contemporary research indicates that psychedelics induce notable neurophysiological changes, some lasting weeks to months after a single dose. However, most evidence derives from acute administration studies and limited post-acute follow-ups. Long-term naturalistic psychedelic users remain critically underexamined, yet may exhibit distinct neurobiological profiles informing...
Quality in SportApril 2, 2026Milena Majchrzyk, Weronika Walendziak, Magdalena Ostaszewska et al.
Introduction and aim of the study. Substance use disorders, including opioid, cocaine, and alcohol dependence, represent a significant global health challenge with high relapse rates despite existing treatments. Ibogaine, a naturally occurring indole alkaloid derived from Tabernanthe iboga, has attracted increasing scientific interest due to its reported ability to reduce withdrawal symptoms...
This piece is a personal and evidence-informed perspective on the current status and future direction of addiction psychiatry in the UK, based on my 30 years as a clinical academic addiction psychiatrist. Alcohol and drug addictions are associated with immense burdens to the individual and society, and this is likely to endure. Challenges facing addiction services to overcome include...