BMC Psychiatry
October 16, 2026
Morfeas Koumas, Markos Apostolakis, Evanthia Bella et al.
Abstract Background Opioid use disorder (OUD) is a chronic relapsing condition associated with substantial mortality. Although medications for opioid use disorder (MOUD) can be effective in reducing opioid use and improving treatment outcomes, relapse to drug use remains common, highlighting the need for adjunctive interventions that address relapse-relevant symptoms not fully targeted by MOUD...
Advances in Therapy
October 14, 2026
Ahmed I Anwar, Abdul-Rahman A Hegazi, M Farris Sawaya et al.
Substance use disorders (SUDs) are a major global health burden, and psychedelic-assisted therapies are now gaining scientific interest, with ibogaine being considered as a candidate for anti-addictive effects across multiple substance classes. Ibogaine is a multi-target indole alkaloid acting on opioid, glutamatergic, serotonergic, and sigma systems with potential to rapidly reduce withdrawal...
Journal of Psychopharmacology
October 8, 2026
Gianluca A. Florineth, Anna L. Boeker, Tobias Bracht et al.
Background: Psilocybin-assisted therapy (PAT) has emerged as a promising intervention for alcohol use disorder (AUD), yet contemporary clinical evidence has not been systematically synthesized to validate its clinical utility and safety profile. Methods: Contemporary clinical trials of PAT for AUD were identified systematically from PubMed, PsycINFO, and Scopus by two independent reviewers....
Research Square
September 30, 2026
Merve Mollaahmetoglu, Joy Krecké, Charlie Oldfield et al.
preprint
Abstract Ketamine is known to have anti-depressant effects and is suggested to reduce substance use. However, little is known about the mechanism of these effects. Given evidence from studies in depression of a greater therapeutic effect in those with a family history of AUD, this latter factor was also investigated as a moderating factor. We used data from the KARE trial, a randomised...
Pharmacology, Biochemistry, and Behavior
September 30, 2026
Camila Pasquini De Souza, Vinicius Theiss De Rosso, Daiane Momo Daneluz et al.
Rats emit 50-kHz ultrasonic vocalizations (USVs), a widely used measure of drug-induced motivational and affective effects and dopaminergic activity. Although psychedelic drugs are promising for addiction treatment, the effects of ayahuasca (AYA) on 50-kHz ultrasonic vocalizations (USVs) remain unclear. We investigated whether acute AYA treatment attenuates lisdexamfetamine (LDX)-induced USVs,...
medRxiv
September 28, 2026
Celia J. A. Morgan, David Nutt
preprint
In the KARE trial, 96 adults with severe alcohol use disorder, abstinent following detoxification, were randomised in a 2×2 factorial design to 3 weekly infusions of ketamine (0.8 mg/kg) or saline, each combined with mindfulness-based psychological support (PS) or alcohol psychoeducation (PE). We re-expressed the trial data on endpoints acceptable to regulators and compared the most and least...
PhilPapers (PhilPapers Foundation)
September 18, 2026
preprint
This paper proposes the Self-Foundation Model by reconsidering the structure of self-worth and psychological fulfillment through a basic question: Where does a person place the value of the self? External conditions such as approval from others, intimate relationships, social status, occupational success, achievement, and income are important sources of enrichment in life. However, when...
Personality and Individual Differences
September 10, 2026
Soufiane Mouatassim, Stacey Callahan, J. F. Chassagne
We analyzed the associations between dispositional mindfulness, the Big Five personality traits, and social media addiction, while investigating whether dispositional mindfulness acts as a moderator in these relationships. The research sample comprised 692 nonclinical French young adults (18–30 years old). The following measurement tools were used: the Five Facet Mindfulness Questionnaire-Short...
The International Journal of Neuropsychopharmacology
September 9, 2026
Todd M Solomon, Robert Barrow, Daniel R Karlin et al.
Abstract Background Effective and well-tolerated pharmacotherapies for generalized anxiety disorder (GAD), which is one of the most common psychiatric disorders, are needed. Aims & Objectives To determine the dose-response relationship of MM120 (lysergide D-tartrate) in adults with moderate to severe GAD. Method This phase 2b, multicenter, randomized, double-blind, placebo-controlled study...
The International Journal of Neuropsychopharmacology
September 9, 2026
Orla Mallon
Abstract Background Opioid Use Disorder (OUD) is associated with substantial morbidity and mortality, with relapse remaining common despite the availability of opioid agonist and antagonist pharmacotherapies. Scotland continues to experience a disproportionate burden of drug-related deaths relative to other parts of the United Kingdom and Europe, reflecting the ongoing clinical and public...
The International Journal of Neuropsychopharmacology
September 9, 2026
David Erritzøe
Abstract Background Recent clinical and neuroscientific work has revived interest in psychedelic-assisted therapies as promising treatments for a range of psychiatric conditions. Mechanistically, classical psychedelics and atypical agents such as ketamine appear to act as catalysts of neural and psychological flexibility, disrupting entrenched patterns of activity in “stuck” brain networks and...
Journal of Psychopharmacology
September 7, 2026
Torsten Passie, Michiel van Elk
Common wisdom in the psychedelic literature suggests that early controlled trials of psychedelic therapy were methodologically flawed. In this review we challenge this view and discuss 11 controlled studies that were conducted in the United States and Canada between 1965 and 1977 to evaluate psychedelic (peak) therapy for individuals suffering from alcohol and opioid use disorder and...
Frontiers in Psychiatry
September 3, 2026
Mary R. Shen, Kwadwo Owusu-Boaitey, Zackari D. Murphy et al.
IntroductionOpioid use disorder (OUD) remains a major public health crisis despite evidence-based medications, including methadone, buprenorphine, and naltrexone. Persistent challenges with treatment retention, access, stigma, and incomplete response highlight the need for adjunctive pharmacotherapies targeting neurobiological systems beyond the mu-opioid receptor.MethodsWe conducted a...
Current Addiction Reports
September 2, 2026
Kathryn Fletcher, Jack Freestone, Nadine Ezard et al.
Abstract Purpose of Review Psychedelic-assisted therapy (PAT) has re-emerged as a potential intervention for substance use disorders (SUDs), yet the psychological mechanisms underlying behaviour change remain poorly synthesised. This scoping review mapped and evaluated proposed psychological processes underpinning PAT in adults with SUDs. Recent Findings Peer-reviewed English-language empirical...
International Journal of Sanskrit Research
September 1, 2026
Authors Names Swapan Samanta
Every contemplative discipline begins because something in the practitioner requires cultivation. This paper asks what becomes of the practitioner's dependence on the cultivating instrument once cultivation succeeds. It proposes the Ceiling Theorem: a pathway of practice becomes a ceiling when the integration it has helped to cultivate grows increasingly contingent on the preservation of that...
Drug and Alcohol Dependence
September 1, 2026
S. Vanegas, J. Marusich, J. Maturano et al.
BACKGROUND AND PURPOSE Cannabinoids, including Δ9-tetrahydrocannabinol (THC) and synthetic CB1 agonists elicit acute psychotropic effects that undergo tolerance with repeated exposure. In contrast, the effects of prolonged cannabinol (CBN) use are unknown. This study examined (1) the effects of repeated CBN administration on classic cannabimimetic outcomes, (2) whether these effects undergo...
Health science reports
September 2026
Shadi Dashtbani, Hadi Ramesh, Narges Norouzkhani et al.
Mindfulness-Based Relapse Prevention (MBRP) combines mindfulness practice with relapse-prevention strategies and has demonstrated efficacy in improving psychological well-being among individuals with substance use disorders. This pilot study evaluated quality-of-life changes following an audio-based mobile MBRP application delivered as an adjunct to methadone maintenance treatment (MMT) among...
European Journal of Pediatrics
August 31, 2026
Neslihan Köse-Kabakcıoğlu, Sultan Ayaz-Alkaya
This study was conducted to identify factors associated with phubbing and to investigate the mediating role of mindfulness in the relationship between digital game addiction and phubbing. A cross-sectional design with mediation analysis was adopted. The study was completed with 2013 voluntary adolescents. The data were collected via paper questionnaires that included validated Turkish versions...
Psychoactives
August 30, 2026
Laura Schäffert, Human-Friedrich Unterrainer
Background: Alcohol use disorder (AUD) remains a leading contributor to global morbidity, yet conventional treatments often yield suboptimal outcomes and high relapse rates. Psilocybin-assisted therapy has re-emerged as a potential intervention for substance use disorders, but its effectiveness and safety in AUD specifically remain to be comprehensively evaluated. Objective: To review and...
August 24, 2026
Bennett Gilbert
Bennett Gilbert asks how interdependence grounds moral obligation, testing panpsychism against the slow work of forming community with other forms of life.