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Clinical Neuropsychopharmacology and Addiction

ISSN 3083-5070

7 papers in the library · 4 citations · publishing 2025-2026

Papers

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Patterns of Psychedelic Use in Italy: Insights from the Global Psychedelic Survey

Clinical Neuropsychopharmacology and Addiction September 1, 2026 Beatrice Dal Bianco, Matteo Buonarroti, Alessandro Lo Jacono et al.

Background: Epidemiological data on psychedelic use in Italy is limited. In this study, Italian responders in the Global Psychedelic Survey 2025 were subanalyzed to describe patterns of use, motivations, subjective experiences, and health correlates. Methods: Adults (≥21 years) with lifetime psychedelic exposure, residing in or born in Italy or San Marino, were surveyed in a web-based,...

Sex- and Age-Stratified Differences in Antidepressant Response to Intranasal Esketamine in Treatment-Resistant Depression: A Secondary Analysis of the REAL-ESK Study

Clinical Neuropsychopharmacology and Addiction June 25, 2026 Luca Persico, Giacomo D’andrea, Clara Cavallotto et al.

Background: Intranasal esketamine (ESK-NS) is an effective treatment for treatment-resistant depression (TRD), but whether antidepressant outcomes differ by sex and age remains insufficiently explored. Methods: This secondary analysis of the REAL-ESK study included 210 patients with TRD treated with ESK-NS in routine clinical practice and assessed at baseline (T0), one month (T1), and three...

Epigenetic Mechanisms of Psychedelics in Addiction: Emerging Evidence and Therapeutic Potential

Clinical Neuropsychopharmacology and Addiction April 17, 2026 Antonio Inserra, Francesca Zoratto, Mauro Pettorruso et al.

Scilight Press is an international academic publisher dedicated to open-access peer-reviewed journals and books. As a global multidisciplinary publisher, we provide a platform for researchers, scholars, and academics to disseminate their work across diverse fields of study. We are committed to advancing knowledge and fostering academic discourse.

Can Substance-Induced Psychoses (SIP) Shed Light on the Paradigm of Schizophrenia?

Clinical Neuropsychopharmacology and Addiction March 10, 2026 Filippo Maria Ferro, Alessio Mosca

Substance-induced psychoses (SIP) may offer a useful vantage point for exploring mechanisms underlying psychotic disorders and for examining the phenomenological specificities of schizophrenia. Clinical observations suggest that a clinically relevant subset of patients does not fully recover after an episode of substance-induced psychosis, raising the hypothesis of more persistent psychotic...

Ketamine-Related Deaths Registered in Scotland 2013–2024

Clinical Neuropsychopharmacology and Addiction January 4, 2026 Amira Guirguis, John Martin Corkery, Fabrizio Schifano

Background: Ketamine, a dissociative anaesthetic and non-competitive NMDA receptor antagonist, has legitimate medical applications. However, rising illicit use across the United Kingdom (UK) has been accompanied by growing reports of toxicity, dependence, and deaths. These have led to renewed policy discussions. Rationale and Aim: Previous national studies have reported ketamine-related deaths...

Novel perspectives for glutamatergic strategies, psychedelics and antipsychotic augmentation in Treatment Resistant Depression: A narrative review

Clinical Neuropsychopharmacology and Addiction September 25, 2025 Stefania Chiappini, Clara Cavallotto, Andrea Miuli et al. 2 citations

Introduction: Treatment-Resistant Depression (TRD) affects approximately 30–50% of patients with Major Depressive Disorder (MDD) who fail to respond to at least two adequate antidepressant trials. This condition presents substantial clinical and functional challenges, and no universally accepted treatment algorithm currently exists. Emerging therapeutic strategies, particularly glutamatergic...

The Cannabis-Psychosis Spectrum: Clinical Manifestations, Conversion Risk, and Therapeutic Strategies

Clinical Neuropsychopharmacology and Addiction August 6, 2025 Valerio Ricci 2 citations

Cannabis-induced psychosis (CIP) represents a significant public health concern in the context of increasing global cannabis use and potency. This review synthesizes current evidence on the epidemiology, neurobiological mechanisms, clinical features, and treatment approaches for cannabis-induced psychotic disorders. Recent epidemiological data indicate rising incidence rates of CIP, with...