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JMIR Research Protocols

ISSN 1929-0748

52 papers in the library · 114 citations · publishing 2017-2026

Papers

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Promoting the Mental Health of Hospital Professionals Through a Workplace-Based Mindfulness Intervention: Protocol for a Randomized Controlled Pilot Trial With a Realist Evaluation (PROMIND)

JMIR Research Protocols August 18, 2026 Ludivine Nohales, Sandrine Touzet, Anne Termoz et al.

Abstract Background Hospital professionals face mental health challenges caused by the high demands of their work. Mindfulness meditation (MM) is a nonpharmacological practice with promising effects in promoting mental health and well-being across various hospital professionals. However, the benefits obtained from its implementation in the context of real work in hospital departments are...

The Effectiveness and Exploratory Cost-Effectiveness of Regular Meditation for Improving Quality of Life: Protocol for a Prospective Longitudinal Cohort Study.

JMIR Research Protocols July 17, 2026 Lillian Ofori Ward, Cate Bailey, Prai Wattanatakulchat et al.

In recent decades, millions of people globally have taken up Buddhist spiritual and secularized meditation practices, such as mindfulness, with the aim of improving their quality of life and well-being. Practitioners are recommended to continue meditating regularly for the long term; however, the effects of regular meditation practice after introductory instruction remain scientifically...

The Efficacy of Hypnotherapy in Reducing Burnout and Related Psychopathologies: Protocol for a Systematic Review and Meta-Analysis.

JMIR Research Protocols July 17, 2026 Santosha Veeramachaneni, Elizabeth Park, Jeffrey Martin et al.

Hypnosis is a focused state of consciousness that enhances concentration, attention, and responsiveness to suggestion. It has shown efficacy in treating psychiatric disorders such as depression, anxiety, and posttraumatic stress disorder (PTSD). However, its potential for addressing burnout and related symptoms remains underexplored. This systematic review and meta-analysis aims to assess the...

Evaluating an Abbreviated Version of Mindfulness-Based Cognitive Therapy Delivered via Telephone or Videoconferencing Compared to Enhanced Usual Care—Treatment for Migraine and Mood (TEAM-M) Study: Protocol for a Three-Arm Multisite Randomized Controlled Feasibility Trial

JMIR Research Protocols June 12, 2026 Chelsea J Siwik, Hallie Tankha, Jacob D Hill et al.

Abstract BackgroundMigraine ranks among the leading causes of disability worldwide. Comorbid depressive symptoms are highly prevalent in patients with migraine and are associated with worsened pain severity, greater migraine-related disability, and poorer migraine prognosis. Despite this burdensome comorbidity, the treatment of these co-occurring disorders has rarely been studied. While...

Telehealth-Delivered Mindfulness-Based Intervention: Protocol for a Randomized Clinical Trial for Individuals With Alcohol Use Disorder.

JMIR Research Protocols May 1, 2026 Megan Kirouac, Daniel S Otero, David I K Moniz-Lewis et al.

Background: Globally, approximately 8.6% of people will meet criteria for alcohol use disorder (AUD) in their lifetimes, with 2.2% meeting criteria for AUD in the past 12 months. In the United States, AUD prevalence is even greater, with 13.9% meeting criteria in the past 12 months. Effective treatments for AUD exist, although most people receive help through mutual support groups (ie,...

Treating Chronic Pain by Modulating Phenomenological and Psychophysiological Indices of Self-Transcendence: Single-Blind Randomized Controlled Clinical Trial Protocol.

JMIR Research Protocols April 23, 2026 Kennedi Childs, Carter Minnick, Geraldine Martorella et al.

Chronic musculoskeletal pain (CMP) imposes a significant psychological, physical, and emotional burden on millions of adults in the United States. A challenge in treating CMP is its tendency to become enmeshed with a person's sense of self. Mindfulness-based interventions (MBIs) offer a promising approach to help patients disentangle pain from their sense of self. However, rigorous research is...

DOI: 10.2196/82362 (opens in new tab) Full text (opens in new tab) Chronic pain Mindfulness-based intervention Perception of pain Self-transcendence

Feasibility of Internet-Based Mind-Body Training for Adults With Subjective Cognitive Decline: Protocol for a Randomized Controlled Trial

JMIR Research Protocols April 20, 2026 Ruchika S Prakash, Madhura Phansikar, Megan Fisher et al.

Abstract BackgroundIn the United States, the prevalence of Alzheimer disease (AD) is projected to double over the next 30 years, with associated familial and societal costs estimated at US $1 trillion annually if current trends continue. Although pharmacological treatments of AD are showing promise, the adoption of healthy lifestyle behaviors, particularly during the preclinical phase of AD,...

Combining Digital Cognitive Behavioral Therapy With Mindfulness Training for Binge Eating Disorder: Protocol for a Feasibility Trial

JMIR Research Protocols April 17, 2026 Margaret Sala, Corey Roos, Dante Ascarrunz et al.

BackgroundCognitive behavioral therapy (CBT) is the most effective treatment for binge eating disorder (BED) but is limited by modest efficacy and low reach of in-person delivery. Combining mindfulness training with CBT could enhance efficacy by targeting emotion dysregulation, a key factor in BED that CBT does not adequately target. Digital delivery can enhance the reach of treatment....

Mindful Movement Programs in Community and University Preschools: Protocol for a Pilot Randomized Controlled Trial

JMIR Research Protocols August 29, 2025 Jacinda K Dariotis, Dana A Eldreth, Rachel Jackson-Gordon et al.

BackgroundChronic stress and emotional and cognitive regulation difficulties during early childhood are associated with risky behaviors and negative outcomes later in life. As preschoolers are at a developmental stage where their emotional and cognitive regulation skills are still emerging, they often rely on external support to manage their emotions and behaviors. Intervening early promotes...

Examining the Dose-Response Effects of Mindfulness Meditation Interventions on Well-Being: Protocol for a Randomized Controlled Trial.

JMIR Research Protocols July 29, 2025 Nicholas Bowles, Alexander Burger, Jonathan N. Davies et al.

Mindfulness meditation has demonstrated modest benefits for mental health and well-being, although the relationship between practice dose and outcomes is unclear. Meta-analyses and randomized controlled trials have shown mixed results so far, although such results may stem from methodological issues rather than reflecting the absence of an underlying effect. Research outside structured programs...

DOI: 10.2196/72786 (opens in new tab) Full text (opens in new tab) Mindfulness meditation mindfulness Practice time Courses Dose-response relationship dose-response +10

The Effectiveness of Virtual Reality-Based Mindfulness Interventions for Managing Stress, Anxiety, and Depression: Protocol for a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

JMIR Research Protocols June 30, 2025 Ravi Shankar, Anjali Bundele, Amartya Mukhopadhyay 8 citations

While traditional mindfulness-based interventions demonstrate effectiveness in improving mental health outcomes, their delivery methods face significant challenges related to accessibility and engagement. Geographic barriers to trained facilitators, time constraints for in-person sessions, and participant dropout rates of 15% to 30% due to perceived monotony limit intervention reach and...

Mindfulness-Based Cognitive Therapy for Life (MBCT-L) Versus Stress Reduction Psychoeducation (SRP) for the Improvement of Mental Well-Being in Health Care and Other Public Sector Staff: Protocol for the Well at Work Randomized Controlled Trial.

JMIR Research Protocols May 26, 2025 Elena Nixon, Shireen Patel, Priya Patel et al.

Mindfulness-based and stress reduction interventions have been recommended by the National Institute for Health and Care Excellence guidelines in England and Wales as effective preventive mental well-being interventions for health care and other public sector staff at risk of poor mental health. This trial aims to assess the effectiveness of the increasingly implemented Mindfulness-Based...

DOI: 10.2196/67695 (opens in new tab) Full text (opens in new tab) Mindfulness-based cognitive therapy Nhs National health service Stress reduction psychoeducation +4

Feasibility Testing a Meditation App for Professionals Working With Youth in the Legal System: Protocol for a Hybrid Type 2 Effectiveness-Implementation Pilot Randomized Controlled Trial.

JMIR Research Protocols April 24, 2025 Ashley D Kendall, Emily Pela, Danielle Amonica et al.

Probation officers and other professionals who work with youth in the legal system often experience high chronic workplace stress, which can contribute over time to elevations in anxiety, depression, and workplace burnout. Emotion dysregulation appears to function as a common mechanism underlying these elevations, and growing evidence suggests it can be improved with mindfulness meditation....

DOI: 10.2196/71867 (opens in new tab) Full text (opens in new tab) Meditation Digital mental health Emotion regulation Juvenile legal system +19

Brief Mobile App-Based Mindfulness Intervention for Indonesian Senior High School Teachers: Protocol for a Pilot Randomized Controlled Trial.

JMIR Research Protocols October 23, 2024 Gede Rasben Dantes, Nice Maylani Asril, Andrian Liem et al. 6 citations

The COVID-19 pandemic has increased the level of anxiety among Indonesian senior high school teachers, who face challenges to treat their mental disorder symptoms that arise during their working hours, as mental health services in Indonesia are limited. Therefore, it is vital to equip schoolteachers in Indonesia with early interventions that are easily available, private, and affordable, and 1...

DOI: 10.2196/56693 (opens in new tab) Full text (opens in new tab) Anxiety Digital mental health Feasibility study Life satisfaction +6

Mindful Self-Compassion Smartphone Intervention for Worker Mental Health in Japan: Protocol for a Randomized Controlled Trial.

JMIR Research Protocols July 15, 2024 Takumu Kurosawa, Koichiro Adachi, Ryu Takizawa 6 citations

Mental health problems among workers cause enormous losses to companies in Japan. However, workers have been considered to have limited access to psychological support because of time constraints, which makes it difficult for them to engage in face-to-face psychological support interventions. This study aimed to present an intervention protocol that describes a randomized controlled trial to...

DOI: 10.2196/53541 (opens in new tab) Full text (opens in new tab) Mental health Mindfulness meditation Mobile phone Preventive intervention +7

Web-Based Mindfulness-Based Cognitive Therapy for Adults With a History of Depression: Protocol for a Randomized Controlled Trial.

JMIR Research Protocols June 18, 2024 Mohammad Hooshmand Zaferanieh, Lu Shi, Meenu Jindal et al. 1 citation

Depression poses a major threat to public health with an increasing prevalence in the United States. Mindfulness-based interventions, such as mindfulness-based cognitive therapy (MBCT), are effective methods for managing depression symptoms and may help fortify existing efforts to address the current disease burden. The in-person group format of MBCT, however, incurs barriers to care such as...

DOI: 10.2196/53966 (opens in new tab) Full text (opens in new tab) Mbct Rct Controlled trials Depressive symptoms +9

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: Protocol for a Pilot Randomized Controlled Trial.

JMIR Research Protocols April 17, 2024 Akash Goel, Bhavya Kapoor, Hillary Chan et al. 2 citations

Chronic pain affects approximately 8 million Canadians (~20%), impacting their physical and mental health while burdening the health care system with costs of upwards of US $60 billion a year. Indeed, patients are often trialed on numerous medications over several years without reductions to their symptoms. Therefore, there is an urgent need to identify new therapies for chronic pain to improve...

DOI: 10.2196/54406 (opens in new tab) Full text (opens in new tab) Psychedelic therapy 3-arm parallel group Cognitive behavior therapy Ketamine hydrochloride +8

Mobile Mindfulness Meditation for Cancer-Related Anxiety and Neuropathy: Protocol for a Randomized Controlled Trial.

JMIR Research Protocols February 12, 2024 Ariel Siritorn Orasud, Mai Uchiyama, Ian Pagano et al. 3 citations

Anxiety- and cancer-related neuropathy are two persistent effects related to treatment for cancer. Mindfulness meditation has been used with substantial impact as a nonpharmacologic intervention to mitigate side and late effects of treatment. Mobile apps are ubiquitous for most of the general population, yet have a particular relevance for cancer survivors, given that physical and geographic...

DOI: 10.2196/47745 (opens in new tab) Full text (opens in new tab) Anxiety Rct Cancer survivorship Clinical trials +10

Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep in Individuals With Insomnia Symptoms: Protocol for a Double-Blind Randomized Controlled Trial

JMIR Research Protocols January 26, 2024 Lindsey L Hildebrand, Alisa Huskey, Natalie S Dailey et al.

Background Cortical hyperarousal and ruminative thinking are common aspects of insomnia that have been linked with greater connectivity in the default mode network (DMN). Therefore, disrupting network activity within the DMN may reduce cortical and cognitive hyperarousal and facilitate better sleep. Objective This trial aims to establish a novel, noninvasive method for treating insomnia through...

A Mindfulness-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain Injury Transitioning Out of Critical Care: Protocol for an Open Pilot Trial.

JMIR Research Protocols October 25, 2023 Alexander Mattia Presciutti, Emily C Woodworth, Elizabeth A Rochon et al.

Background: Caregivers of patients with severe acute brain injuries (SABI) that lead to coma and require intensive care unit (ICU) treatment often experience chronic emotional distress. To address this need, we developed the Coma Family (COMA-F) program, a mindfulness-based resiliency intervention for these caregivers. Objective: We will conduct an open pilot trial of COMA-F (National...

Mindfulness-Based App to Reduce Stress in Caregivers of Persons With Alzheimer Disease and Related Dementias: Protocol for a Single-Blind Feasibility Proof-of-Concept Randomized Controlled Trial.

JMIR Research Protocols October 13, 2023 Emily C Woodworth, Ellie A Briskin, Evan Plys et al.

Background: Informal caregivers (ie, individuals who provide assistance to a known person with health or functional needs, often unpaid) experience high levels of stress. Caregiver stress is associated with negative outcomes for both caregivers and care recipients. Mindfulness-based interventions (MBIs) show promise for improving stress, emotional distress, and sleep disturbance in caregivers...

DOI: 10.2196/50108 (opens in new tab) Full text (opens in new tab) Mindfulness Dementia Protocol Randomized controlled trial +2

Technology-Enabled Intervention to Enhance Mindfulness, Safety, and Health Promotion Among Corrections Professionals: Protocol for a Prospective Quasi-Experimental Trial.

JMIR Research Protocols September 22, 2023 Diane Elliot, Kerry Kuehl, Carol DeFrancesco et al.

Background: Correction professionals are a highly stressed workforce with heightened risks for depression, suicide, obesity, cardiovascular disease, and injury. These professionals, largely hidden from view, have received little study concerning means to improve their safety, health, and well-being. In other settings, mindfulness has resulted in lowered stress, along with other benefits. We...

App-Based Mindfulness Meditation for People of Color Who Experience Race-Related Stress: Protocol for a Randomized Controlled Trial

JMIR Research Protocols August 28, 2023 Giovanni Ramos, Adrian Aguilera, Amanda K Montoya et al.

BackgroundPeople of color (POC) who experience race-related stress are at risk of developing mental health problems, including high levels of stress, anxiety, and depression. Mindfulness meditation may be especially well suited to help POC cope, given its emphasis on gaining awareness and acceptance of emotions associated with discriminatory treatment. However, mindfulness meditation rarely...

Effectiveness of Mindfulness-Based Cognitive Therapy With Follow-Up Sessions for Pharmacotherapy-Refractory Anxiety Disorders: Protocol for a Feasibility Randomized Controlled Trial

JMIR Research Protocols August 28, 2023 Mitsuhiro Sado, Akira Ninomiya, Maki Nagaoka et al.

BackgroundAugmented mindfulness-based cognitive therapy (MBCT) with treatment as usual (mainly pharmacotherapy) is reported to be effective after treatment for anxiety disorders. However, whether its effectiveness persists in the long term is unclear. ObjectiveThis study aims to examine the feasibility, acceptability, and effectiveness of a follow-up program by conducting a feasibility...