BACKGROUND AND PURPOSE Cannabinoids, including Δ9-tetrahydrocannabinol (THC) and synthetic CB1 agonists elicit acute psychotropic effects that undergo tolerance with repeated exposure. In contrast, the effects of prolonged cannabinol (CBN) use are unknown. This study examined (1) the effects of repeated CBN administration on classic cannabimimetic outcomes, (2) whether these effects undergo...
Health science reportsSeptember 2026Shadi Dashtbani, Hadi Ramesh, Narges Norouzkhani et al.
Mindfulness-Based Relapse Prevention (MBRP) combines mindfulness practice with relapse-prevention strategies and has demonstrated efficacy in improving psychological well-being among individuals with substance use disorders. This pilot study evaluated quality-of-life changes following an audio-based mobile MBRP application delivered as an adjunct to methadone maintenance treatment (MMT) among...
This study was conducted to identify factors associated with phubbing and to investigate the mediating role of mindfulness in the relationship between digital game addiction and phubbing. A cross-sectional design with mediation analysis was adopted. The study was completed with 2013 voluntary adolescents. The data were collected via paper questionnaires that included validated Turkish versions...
Background: Alcohol use disorder (AUD) remains a leading contributor to global morbidity, yet conventional treatments often yield suboptimal outcomes and high relapse rates. Psilocybin-assisted therapy has re-emerged as a potential intervention for substance use disorders, but its effectiveness and safety in AUD specifically remain to be comprehensively evaluated. Objective: To review and...
Bennett Gilbert asks how interdependence grounds moral obligation, testing panpsychism against the slow work of forming community with other forms of life.
Objectives Smartphone addiction among adolescents is an emerging public health concern affecting psychological well-being and physiological health. Limited research studies exist on integrated, low-cost, school-based interventions addressing both domains. This study helps to evaluate the effectiveness of laughter yoga and mindfulness on psychological well-being and physiological parameters...
Background: Psychedelic-assisted psychotherapy (PAP) shows promise for substance use disorders (SUDs), yet the respective contributions of pharmacological, experiential, psychotherapeutic, and contextual factors remain insufficiently understood. Objective: To synthesize contemporary clinical evidence on PAP for SUDs, with particular attention to therapeutic frameworks, dosing strategies,...
This manuscript develops the Principle of Structural Dependence (PSD) as a general organisational constraint for theories and empirical models of awareness and cognitive capacities. PSD proposes that measurable differences in a capacity require corresponding differences in the organisation relevant to supporting that capacity. The principle is deliberately modest: it does not specify what...
Substance use disorders represent a significant public health concern in Pakistan, with methamphetamine showing increasing prevalence, particularly among adults. In light of the escalating incidence of methamphetamine-type stimulant (MTS) consumption observed in Pakistan, this research endeavor sought to assess the efficacy of Mindfulness integrated cognitive behavior therapy (MICBT) for...
BACKGROUND AND AIMS: This study qualitatively explored psychological change processes as described by participants and therapists within a phase 2a clinical trial evaluating the safety, tolerability, and preliminary efficacy of a single dose of intranasal 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT; BPL-003) administered alongside psychological support and manualised cognitive behavioural...
Psychiatry ResearchAugust 1, 2026C. Bharat, Xin-Tong Huang, G. Campbell et al.
BACKGROUND Interest in cannabinoids for mental and substance use disorders is increasing. We examined experimental and observational evidence for treating these disorders and their symptoms. METHODS Systematic review and meta-analysis (PROSPERO CRD42023467536). We searched CENTRAL, MEDLINE, Embase and PsycINFO to May 2025 for studies of cannabinoids in adults (≥18 years) with ADHD, anxiety,...
Background: Adolescents’ life now revolves around social media, which offers them chances for amusement, education, and communication. But extreme use can effect in social media addiction (SMA), which is marked by obsessive use, lack of control, withdrawal symptoms, and interference with day-to-day activities. Adolescents (ages 10 to 19) are especially vulnerable because of social,...
Addictive BehaviorsAugust 1, 2026Sarret Seng, Chizimuzo T C Okoli, Lovoria B Williams et al.
Metacognition - the capacity to monitor, interpret, and regulate cognitive processes - is essential for adaptive behavioral regulation. Evidence on how substance use relates to metacognitive functioning remains heterogeneous across substances and study designs. This systematic review synthesized evidence examining the relationship between substance use and metacognition among adults. Following...
The present study examined the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) in reducing emotion dysregulation among patients with SUD. A randomized controlled trial with a pre-test and post-test design was conducted at Umeed-e-Shifa Rehabilitation Centre, Bani Gala. Forty male participants aged 20–40 years meeting DSM-5-TR criteria for SUD were selected through purposive sampling and...
Mindfulness is defined as nonjudgmental, nonreactive, metacognitive attention focused on the experience of the present moment, without being caught up in thoughts about the past or future (Garland, 2007). Mindfulness-based interventions are gaining growing interest in the field of clinical psychology. This third-wave cognitive behavioral therapy (CBT) has been shown to be effective in the...
Since the introduction of disulfiram in 1951 (the first ever Food and Drug Administration (FDA)-approved medication for substance use disorders (SUDs)) (1), only seven other individual medications have been approved for the treatment of SUDs. While the repurpose of medications and different formulations increase the total number of FDA-approved medicines (Table 1 and(2)), the arsenal of...
Introduction Substance use disorder (SUD) is a major global health issue, contributing significantly to the disease burden. Despite this, effective treatments for SUD remain limited. Ketamine has shown potential as a treatment, yet no meta-analysis has assessed its efficacy for SUD. This study aimed to evaluate the efficacy and safety of ketamine in treating SUD. Methods Multiple databases were...
Substance use disorders (SUDs) affect the lives of more than 35 million people worldwide, according to 2019 data from the United Nations Office on Drugs and Crime. Current evidence suggests that MBIs may mitigate the harmful psychosocial effects associated with SUDs. Although MBIs have been extensively studied for efficacy, there remains a growing need to synthesize evidence from relevant...
Background and Purpose: Ketamine has emerged as a promising treatment candidate for alcohol use disorder (AUD), yet whether its S- and R-enantiomers differentially regulate ongoing binge-like alcohol self-administration remains unknown. We compared the acute and repeated effects of S- and R-ketamine in a chronic binge-like, front-loaded operant alcohol self-administration paradigm. Experimental...