19 papers in the library · 3,948 citations · publishing 2007-2026
BJPsych Open May 13, 2026 Zeina Beidas, Anya Ragnhildstveit, Adam Blackman et al.
Microdosing psilocybin for major depressive disorder: study protocol for a phase II double-blind placebo-controlled randomised partial crossover trial - CORRIGENDUM.
Research Square February 23, 2026 Rotem Petranker, Norman A. S. Farb, Omer A. Syed et al.
Abstract IMPORTANCE Microdosing psilocybin may be a novel treatment for major depressive disorder (MDD). OBJECTIVE Assessing the antidepressant effects and safety of repeated low doses of psilocybin in participants diagnosed with MDD. DESIGN This was a Phase II, randomized, double-blind, placebo-controlled clinical trial. SETTING The trial was conducted from July 2022 to December 2024 at two...
BJPsych Open February 16, 2026 Zeina Beidas, Anya Ragnhildstveit, Adam Blackman et al. 1 citation
BACKGROUND: Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting roughly 322 million people. Recently, doses of psilocybin have shown promise in treating mood disorders, sparking interest in other dosing practices. According to anecdotal reports and observational studies, microdosing psilocybin yields benefits to mental health; however, rigorously controlled...
November 16, 2025 Zeina Beidas, Anya Ragnhildstveit, Adam Blackman et al. preprint
Background: Major depressive disorder (MDD) is the leading cause of disability worldwide, affecting roughly 322 million people. Recently, doses of psilocybin have shown promise in treating mood disorders, sparking interest in other dosing practices. According to anecdotal reports and observational studies, microdosing psilocybin yields benefits to mental health; however, rigorously controlled...
Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Saampras Ganesan, Fernando A Barrios, Ishaan Batta et al. 6 citations
Meditation is a family of ancient and contemporary contemplative mind-body practices that can modulate psychological processes, awareness, and mental states. Over the last 40 years, clinical science has manualized meditation practices and designed various meditation interventions that have shown therapeutic efficacy for disorders including depression, pain, addiction, and anxiety. Over the past...
Biological psychiatry. Cognitive neuroscience and neuroimaging April 1, 2025 Clemens C C Bauer, Daniel A Atad, Norman A. S. Farb et al. 3 citations
The observer effect (OE), the idea that observing a phenomenon changes it, has important implications across scientific disciplines involving measurement and observation. While often viewed as a confounding variable to control for, this paper argues that the OE should be seriously accounted for, explored, and systematically leveraged in research and clinical settings. Specifically, mindfulness...
PLoS One September 7, 2022 Geissy Lainny de Lima-Araújo, Geovan Menezes de Sousa, Thatiane Aparecida Mendes et al. 64 citations
Interoception is a collection of different representations of signals originating within the body. The way of perceiving these signals seems to be related to both emotion regulation and dysregulation, and its dysfunction is implicated across a variety of affective disorders. There is a growing body of research investigating the relationship between mindfulness meditation practices and...
NeuroImage Clinical 2022 Norman A. S. Farb, Philip A. Desormeau, Adam K. Anderson et al. 15 citations
BACKGROUND: Neural reactivity to dysphoric mood induction indexes the tendency for distress to promote cognitive reactivity and sensory avoidance. Linking these responses to illness prognosis following recovery from Major Depressive Disorder informs our understanding of depression vulnerability and provides engagement targets for prophylactic interventions. METHODS: A prospective fMRI...
UNC Libraries November 8, 2020 Norman A. S. Farb, Philippe R. Goldin, Barbara L. Fredrickson et al.
Contemporary scholarship on mindfulness casts it as a form of purely non-evaluative engagement with experience. Yet, traditionally mindfulness was not intended to operate in a vacuum of dispassionate observation, but was seen as facilitative of eudaimonic mental states. In spite of this historical context, modern psychological research has neglected to ask the question of how the practice of...
Frontiers in Psychology July 10, 2020 Rotem Petranker, Thomas Anderson, Norman A. S. Farb 66 citations
Psychedelics have a checkered past, alternately venerated as sacred medicines and vilified as narcotics with no medicinal or research value. After decades of international prohibition, a growing dissatisfaction with conventional mental health care and the pioneering work of the Multidisciplinary Association for Psychedelic Science (MAPS) and others has sparked a new wave of psychedelic...
Frontiers in Human Neuroscience 2020 Helen Y. Weng, Jarrod A Lewis-Peacock, Frederick M Hecht et al. 9 citations
Meditation practices are often used to cultivate interoception or internally-oriented attention to bodily sensations, which may improve health via cognitive and emotional regulation of bodily signals. However, it remains unclear how meditation impacts internal attention (IA) states due to lack of measurement tools that can objectively assess mental states during meditation practice itself, and...
Journal of Consulting and Clinical Psychology February 1, 2019 Z. Segal, A. Anderson, T. Gulamani et al.
Background: To investigate whether usage of treatment-acquired regulatory skills is associated with prevention of depressive relapse/recurrence. Method: Remitted depressed outpatients entered a 24-month clinical follow up after either 8 weekly group sessions of cognitive therapy (CT; N = 84) or mindfulness-based cognitive therapy (MBCT; N = 82). The primary outcome was symptom return meeting...
Psychopharmacology January 2, 2019 Thomas Anderson, Rotem Petranker, Daniel Rosenbaum et al. 171 citations
RationaleMicrodosing psychedelics-the regular consumption of small amounts of psychedelic substances such as LSD or psilocybin-is a growing trend in popular culture. Recent studies on full-dose psychedelic psychotherapy reveal promising benefits for mental well-being, especially for depression and end-of-life anxiety. While full-dose therapies include perception-distorting properties,...
Psychological Inquiry October 2, 2015 Eric L Garland, Norman A. S. Farb, Philippe R. Goldin et al. 228 citations
Over the past several decades, a corpus of research has emerged detailing the therapeutic outcomes and processes of mindfulness. The emergence of the field of contemplative science has given rise t...
Frontiers in Psychology June 9, 2015 Norman A. S. Farb, Jennifer Daubenmier, Cynthia Price et al. 630 citations
Interoception can be broadly defined as the sense of signals originating within the body. As such, interoception is critical for our sense of embodiment, motivation, and well-being. And yet, despite its importance, interoception remains poorly understood within modern science. This paper reviews interdisciplinary perspectives on interoception, with the goal of presenting a unified perspective...
Social Cognitive and Affective Neuroscience June 11, 2012 Norman A. S. Farb, Zindel V. Segal, Adam K. Anderson 566 citations
One component of mindfulness training (MT) is the development of interoceptive attention (IA) to visceral bodily sensations, facilitated through daily practices such as breath monitoring. Using functional magnetic resonance imaging (fMRI), we examined experience-dependent functional plasticity in accessing interoceptive representations by comparing graduates of a Mindfulness-Based Stress...
The Canadian Journal of Psychiatry February 1, 2012 Norman A. S. Farb, Adam K. Anderson, Zindel V. Segal 361 citations
Mindfulness involves nonjudgmental attention to present-moment experience. In its therapeutic forms, mindfulness interventions promote increased tolerance of negative affect and improved well-being. However, the neural mechanisms underlying mindful mood regulation are poorly understood. Mindfulness training appears to enhance focused attention, supported by the anterior cingulate cortex and the...
Emotion February 1, 2010 Norman A. S. Farb, Adam K. Anderson, Helen S. Mayberg et al. 523 citations
Recovery from emotional challenge and increased tolerance of negative affect are both hallmarks of mental health. Mindfulness training (MT) has been shown to facilitate these outcomes, yet little is known about its mechanisms of action. The present study employed functional MRI (fMRI) to compare neural reactivity to sadness provocation in participants completing 8 weeks of MT and waitlisted...
Social Cognitive and Affective Neuroscience August 13, 2007 Norman A. S. Farb, Zindel V. Segal, Helen S. Mayberg et al. 1,305 citations
It has long been theorised that there are two temporally distinct forms of self-reference: extended self-reference linking experiences across time, and momentary self-reference centred on the present. To characterise these two aspects of awareness, we used functional magnetic resonance imaging (fMRI) to examine monitoring of enduring traits ('narrative' focus, NF) or momentary experience...