Apollo (University of Cambridge)
July 3, 2026
Tim Dalgleish
Kuyken et al’s1 individual participant data (IPD) meta-analysis of mindfulness-based cognitive therapy (MBCT) for the prevention of depressive relapse/recurrence has supported MBCT’s dissemination as a frontline treatment for depression. MBCT is now recommended in multiple clinical guidelines including the National Institute for Health and Care Excellence in the United Kingdom and is widely...
Stress and health : journal of the International Society for the Investigation of Stress
December 1, 2025
Maris Vainre, Tim Dalgleish, Tia Bendriss-Otiko et al.
2 citations
Employers and universities globally subsidise access to mindfulness-based programmes (MBPs) for their employees and students to improve work performance, despite unclear evidence. This paper offers the highest quality synthesis of MBPs' impact on work performance in academic and occupational settings to date (PROSPERO #191756). On 2nd August 2024, we searched eight databases. The primary...
JCPP Advances
October 7, 2025
Carolina Guzman Holst, Simona Skripkauskaite, Jack L. Andrews et al.
This study explored adolescent's mental health trajectories over the course of a school-based mindfulness-based intervention trial (MYRIAD). It examined whether intervention condition (mindfulness vs. teaching-as-usual), individual-level and contextual-level factors were associated with different trajectories. This pre-registered study used data from 11- to 14-year-olds who participated in the...
BJPsych Open
June 1, 2025
Anna Borissova, Allan H. Young, Mitul A. Mehta et al.
Aims: Ketamine and behavioural activation (BA) reduce levels of anhedonia in major depressive disorder (MDD), though neither resolves anhedonia. Combining these treatments could yield additive or even multiplicative benefits. This poster summarises the development of a PhD fellowship proposal, discussing: (1) the initial patient and public involvement (PPI) interviews, exploring views on...
The British journal of psychiatry : the journal of mental science
April 1, 2025
Jesus Montero-Marin, Verena Hinze, Shannon Maloney et al.
4 citations
Personalised management of recurrent depression, considering individual patient characteristics, is crucial. This study evaluates the potentially different mediating role of mindfulness skills in managing recurrent depression using mindfulness-based cognitive therapy (MBCT) among people with varying depression severity. Data from the Prevention of Depressive Relapse or Recurrence (PREVENT)...
Journal of Consulting and Clinical Psychology
September 1, 2024
Barnaby D. Dunn, Laura Warbrick, Rachel Hayes et al.
10 citations
Mindfulness-based cognitive therapy (MBCT) is a viable alternative to maintenance antidepressant medication (M-ADM) to reduce risk of relapse/recurrence (RR) in recurrent depression, but its mechanism of action is not yet fully articulated. This secondary analysis of the PREVENT trial examined if MBCT with support to taper medication (MBCT-TS) reduces risk of RR in part by enhancing positive...
BMJ mental health
February 28, 2024
Maris Vainre, Tim Dalgleish, Peter Watson et al.
1 citation
Mindfulness-based programmes (MBPs) are increasingly offered at work, often in online self-guided format. However, the evidence on MBPs' effect on work performance (WP) is inconsistent. This pragmatic randomised controlled feasibility trial assessed procedural uncertainties, intervention acceptability and preliminary effect sizes of an MBP on WP, relative to an alternative intervention. 241...
Nature. Mental health
July 10, 2023
Julieta Galante, Claire Friedrich, Napaporn Aeamla-Or et al.
102 citations
Mindfulness-based programmes (MBPs) are widely used to prevent mental ill-health that is becoming the leading global cause of morbidity. Evidence suggests beneficial average effects but wide variability. We aimed to confirm the effect of MBPs on psychological distress, and to understand whether and how baseline distress, gender, age, education, and dispositional mindfulness modify the effect of...
Prevention Science
August 1, 2022
Kate Tudor, Shannon Maloney, Anam Raja et al.
There is evidence that universal school-based mindfulness training (SBMT) can have positive effects for young people. However, it is unknown who benefits most from such training, how training exerts effects, and how implementation impacts effects. This study aimed to provide an overview of the evidence on the mediators, moderators, and implementation factors of SBMT, and propose a conceptual...
Clinical psychological science : a journal of the Association for Psychological Science
April 29, 2022
Z. Cohen, R. DeRubeis, Rachel Hayes et al.
Depression is highly recurrent, even following successful pharmacological and/or psychological intervention. We aimed to develop clinical prediction models to inform adults with recurrent depression choosing between antidepressant medication (ADM) maintenance or switching to mindfulness-based cognitive therapy (MBCT). Using previously published data (N = 424), we constructed prognostic models...
Behaviour Research and Therapy
May 25, 2021
Caitlin Hitchcock, Christina Haag, Alicia J. Smith et al.
preprint
The ability to retrieve specific, single-incident autobiographical memories has been consistently posited as a predictor of recurrent depression. Elucidating the role of autobiographical memory specificity in patient-response to depressive treatments may improve treatment efficacy and facilitate use of science-driven interventions. We used recent methodological advances in individual patient...
Journal of Child Psychology and Psychiatry
October 22, 2018
Darren Dunning, Kirsty Griffiths, Willem Kuyken et al.
596 citations
BACKGROUND: Mindfulness based interventions (MBIs) are an increasingly popular way of attempting to improve the behavioural, cognitive and mental health outcomes of children and adolescents, though there is a suggestion that enthusiasm has moved ahead of the evidence base. Most evaluations of MBIs are either uncontrolled or nonrandomized trials. This meta-analysis aims to establish the efficacy...
JAMA Psychiatry
April 28, 2016
Willem Kuyken, Fiona C Warren, Rod S. Taylor et al.
815 citations
IMPORTANCE: Relapse prevention in recurrent depression is a significant public health problem, and antidepressants are the current first-line treatment approach. Identifying an equally efficacious nonpharmacological intervention would be an important development. OBJECTIVE: To conduct a meta-analysis on individual patient data to examine the efficacy of mindfulness-based cognitive therapy...
The Lancet
July 4, 2015
Willem Kuyken, Rachel Hayes, B. Barrett et al.
BACKGROUND Individuals with a history of recurrent depression have a high risk of repeated depressive relapse or recurrence. Maintenance antidepressants for at least 2 years is the current recommended treatment, but many individuals are interested in alternatives to medication. Mindfulness-based cognitive therapy (MBCT) has been shown to reduce risk of relapse or recurrence compared with usual...