J Int Med Res
March 29, 2026
Hui Li, Jingjing Deng, Tao Liu et al.
Ketamine, a dissociative anesthetic, has been extensively used in clinical anesthesia and sedation. However, its use in general anesthesia is gradually declining because of numerous adverse effects. In 2019, esketamine was introduced to the Chinese market. This narrative review aimed to summarize the current status of clinical applications and research progress of esketamine and to explore its...
Frontiers in Psychiatry
2026
Hang Yu, Yuqiong Zhu, Jie Wang et al.
Esketamine has a significant and rapid antidepressant effect. Although studies have shown that Neuregulin 1 (NRG1) and it's signaling pathway are associated with depression, the possible regulatory relationship of esketamine on the NRG1-ErbB4 pathway is not yet clear. To induce depressive-like behavior in mice, a Chronic Social Defeat Stress (CSDS) model was established. Behavioral indicators...
European Journal of Pharmacology
November 15, 2024
Hui Li, Wen Hu, Zhen Wu et al.
11 citations
Microglia-mediated neuroinflammation is critical in the pathogenesis of sepsis-associated encephalopathy(SAE). Identifying the key factors that inhibit microglia-mediated neuroinflammation holds promise as a potential target for preventing and treating SAE. Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has been proposed to possess protective and therapeutic...
Science (New York, N.Y.)
August 9, 2024
Min Chen, Shuangshuang Ma, Hanxiao Liu et al.
87 citations
Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ketamine's antidepressant action. We found that ketamine injection in depressive-like mice specifically blocks NMDARs in lateral habenular...
ACS Chemical Neuroscience
April 17, 2024
Hui Li, Qiong Ye, Da Wang et al.
The cannabinoid receptor 1 (CB1) is famous as the target of Δ9-tetrahydrocannabinol (THC), which is the active ingredient of marijuana. Suppression of CB1 is frequently suggested as a drug target or gene therapy for many conditions (e.g., obesity, Parkinson's disease). However, brain networks affected by CB1 remain elusive, and unanticipated psychological effects in a clinical trial had dire...
Frontiers in Psychology
February 17, 2021
Ping Liu, Xiaofeng Wang, Dan Li et al.
As one of the foundations of existential positive psychology, self-transcendence can bring positive intrapersonal and interpersonal outcomes, especially in the COVID-19 era in which people are suffering huge mental stress. Based on Schwartz's theory of human basic values, the current study combines variable-centered and person-centered approaches to examine the relationships between...
Frontiers in Neurology
September 18, 2019
Yang Wang, Yun Qin, Hui Li et al.
Internet addiction (IA) has become a global mental and social problem, which may lead to a series of psychiatric symptoms including uncontrolled use of internet, and lack of concentration. However, the exact pathophysiology of IA remains unclear. Most of functional connectivity studies were based on pre-selected regions of interest (ROI), which could not provide a comprehensive picture of the...
Linghui Dong, Hui Li, Kaiyue Han et al.
Abstract Background Accurate differentiation between minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS) is a significant clinical challenge because behavioral assessments are often constrained by patients' motor impairments and fluctuating arousal. Beyond diagnostic classification, clarifying the specific brain network mechanisms that sustain residual consciousness in...