Brain Research Bulletin
August 1, 2026
Rui Dong, Jiaxin Liu, Yumei Shen et al.
Trigeminal neuralgia (TN) is a debilitating orofacial pain condition frequently complicated by anxiety and depression, forming a self-reinforcing pain-affect cycle with limited therapeutic options. A TN mouse model with anxiety-like behavior was established using partial infraorbital nerve transection (pIONT). Esketamine (ES) (5 or 10 mg/kg) was administered intraperitoneally from postoperative...
Brain, behavior, and immunity
May 1, 2026
Shihuan Tian, E. Huang, Guoxia Zhang et al.
The increasing non-medical use of dextromethorphan (DM), particularly among adolescents, has raised concerns regarding its potential neurobiological consequences. However, the precise mechanisms underlying its neurotoxicity, particularly the involvement of the gut microbiota, remain unclear. A novel probiotic strain, Bacillus aerolatus CX253, has demonstrated the capacity to regulate gut...
European journal of anaesthesiology
January 29, 2026
Tiantian Chu, Xiaoling Peng, Keliang Wan et al.
2 citations
Postpartum depression (PPD) is a common complication after childbirth, especially in primiparae. This trial sought to evaluate whether prophylactic administration of esketamine during the perinatal period could prevent PPD in primiparae without predisposition to prenatal depression. A prospective, double-blind, multicentre, randomised controlled trial. Three academic hospitals. Primiparae...
Behaviour Research and Therapy
November 1, 2025
Yaoyao Zhang, Xin Liu, Huimin Wu et al.
The components of mindfulness include awareness and acceptance. However, the effects of awareness and acceptance on psychological stress in adolescents remain controversial, and the underlying cognitive processes less attention. Therefore, this study aimed to examine their independent effects, and the relevant cognitive processes. A cross-sectional survey study (Study 1, N = 3304, Mage = 15.53...
Journal of Medical Internet Research
June 2, 2025
Shu Jing, Zhenwei Dai, Xiaoyang Liu et al.
1 citation
correction
[This corrects the article DOI: 10.2196/71741.].
Journal of Medical Internet Research
May 23, 2025
Shu Jing, Zhenwei Dai, Xiaoyang Liu et al.
5 citations
Nursing students experience disproportionately high rates of mental health challenges, underscoring the urgent need for innovative, scalable interventions. Web-based mindfulness programs, and more recently, neurofeedback-enhanced approaches, present potentially promising avenues for addressing this critical issue. This study aimed to explore the effectiveness of the neurofeedback-assisted...
Environmental Science & Technology
May 6, 2025
Si-Ying Li, Dongdong Ma, Wen-Jun Shi et al.
3 citations
Esketamine (ESK), a new psychoactive substance known for its strong hallucinogenic effect, has been detected in surface water worldwide. The toxicity of ESK to fish at a certain environmental concentration remains unclear. In this study, zebrafish embryos and ZF4 cells were exposed to ESK (0, 0.12, 1.02, and 10.6 μg L-1, marked by SC, LC, MC, and HC, respectively) for 14 days post fertilization...
BMC Anesthesiology
December 5, 2024
Xing Lin, Xin Liu, Huoming Huang et al.
15 citations
Prior meta-analyses have established the potential of intravenous ketamine in safeguarding against neurocognitive impairment, but the efficacy of intravenous esketamine for the prevention of perioperative neurocognitive disorders (PND) remains uncertain. The primary aim of this meta-analysis was to conduct a comprehensive evaluation of the effects of esketamine on PND in adult surgical patients...
Bulletin of environmental contamination and toxicology
March 31, 2024
Si-Ying Li, Wen-Jun Shi, Dong-Dong Ma et al.
9 citations
Esketamine (ESK) is the S-enantiomer of ketamine racemate (a new psychoactive substance) that can result in illusions, and alter hearing, vision, and proprioception in human and mouse. Up to now, the neurotoxicity caused by ESK at environmental level in fish is still unclear. This work studied the effects of ESK on behaviors and transcriptions of genes in dopamine and GABA pathways in zebrafish...
British Journal of Pharmacology
July 1, 2019
Panos Zanos, Jaclyn N. Highland, Xin Liu et al.
(R)-Ketamine (arketamine) may have utility as a rapidly acting antidepressant. While (R)-ketamine has lower potency than (R,S)-ketamine to inhibit NMDA receptors in vitro, the extent to which (R)-ketamine shares the NMDA receptor-mediated adverse effects of (R,S)-ketamine in vivo has not been fully characterised. Furthermore, (R)-ketamine is metabolised to (2R,6R)-hydroxynorketamine (HNK),...
Stress and Health
November 22, 2013
Xinghua Liu, Wei Xu, Yuzheng Wang et al.
72 citations
This article reports a randomized controlled trial to investigate whether mindfulness training can successfully improve inner peace in participants with no known mental disorder. Fifty-seven participants were randomized to either mindfulness training (n = 29) or wait-list control (n = 28). The experience sampling method was used to measure the fleeting momentary experience of inner peace in...