Hanxiao Liu

Brain region-specific action of ketamine as a rapid antidepressant.

Science August 9, 2024 Min Chen, Shuangshuang Ma, Hanxiao Liu et al. 87 citations

Ketamine has been found to have rapid and potent antidepressant activity. However, despite the ubiquitous brain expression of its molecular target, the N-methyl-d-aspartate receptor (NMDAR), it was not clear whether there is a selective, primary site for ketamine's antidepressant action. We found that ketamine injection in depressive-like mice specifically blocks NMDARs in lateral habenular...