Journal of Pharmacology and Experimental Therapeutics
1984
Michael E. Trulson, D W Preussler, V M Trulson
Previous studies from our laboratory have demonstrated that there are a number of important dissociations between the effects of hallucinogenic drugs on the activity of serotonin-containing dorsal raphe neurons and behavior in freely moving cats. In the present study, we extended this analysis to serotonergic units in the nucleus centralis superior (NCS) and nucleus raphe pallidus (RPA)....
European Journal of Pharmacology
December 1, 1983
Michael E. Trulson, Terriann Crisp, Leslie J. Henderson
21 citations
The characteristic behavioral effects of mescaline in cats were nearly completely blocked by pretreatment with low doses of either a specific serotonin antagonist (methysergide) or a dopamine specific antagonist (haloperidol). These blocking effects were not due to non-specific actions, since methysergide did not block the behavioral effects of apomorphine, and haloperidol did not block the...
Brain Research
November 21, 1983
P H Hutson, M D Tricklebank, G Curzon
13 citations
Analgesia induced by footshock (2 mA, 30 s) is decreased by the 5-HT releaser, fenfluramine, and the rapidly acting 5-HT agonist, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT). These decreases are blocked by the 5-HT antagonists, cyproheptadine and methiothepin. However, the antagonists when given alone do not influence shock-induced analgesia. Therefore, analgesia induced by brief footshock in...
European Journal of Pharmacology
July 1, 1983
Rats trained to discriminate 1.0 mg/kg of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant choice task were administered doses of mescaline, LSD, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), quipazine, TFMPP and RU-24969. The DOM-stimulus generalized to the three hallucinogenic agents and to quipazine, but not to the purported serotonin agonists TFMPP or...
Pharmacology, Biochemistry, and Behavior
April 1, 1983
R Santos, E A Carlini
25 citations
The effects of serotonin precursors (L-5-hydroxytryptophan and L-tryptophan, with or without MAO inhibitors) and of agonists (quipazine and 5-methoxy-N,N-dimethyltryptamine-MeO-DMT) were studied in 3 day REM-deprived or control rats, by recording the presence of the serotonin syndrome and the number of head shakes. The REM sleep-deprived rats showed a larger incidence of the serotonin syndrome...
Chemischer Informationsdienst
March 8, 1983
R. A. Glennon, R. Young, F. Benington et al.
AbstractDurch Persulfat‐Oxidation des Fluorphenols (I) und anschließende Alkylierung des gebildeten Fluorhydrochinons erhält man den Dimethylether (II), der über die Verbindungen (III) und (IV) in das arylsubstituierte Aminopropan (V) umgewandelt wird.
Drug Development Research
1983
C. J. E. Niemegeers, Françis C. Colpaert, J.e. Leysen et al.
58 citations
Abstract An intravenous dose of 20.0 mg/kg of mescaline induced a reproducible head‐twitch response in rats. Drugs with very different pharmacological activities were tested for potential inhibition of this response. Among these drugs were a large number of serotonin antagonists, including several members of the recently described selective S 2 antagonists of which ketanserin (a potent vascular...
Palgrave Macmillan UK eBooks
1983
Sven Ove Ögren, Kjell Fuxé, Odd‐geir Berge et al.
11 citations
The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral evidence for sub- and supersensitivity depending on 5-HT agonist dose and types of behavior examined. Thus, chronic treatment with all three drugs reduced head twitches induced by a high dose of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine...
Neuroscience Letters
December 23, 1982
T Archer, S O Ogren, S B Ross
24 citations
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), a serotonin (5-HT) agonist, fenfluramine and p-chloroamphetamine (PCA), which are 5-HT releasers, produce deficits in fear retention as indicated by a notable lack of the immobility resulting from inescapable shocks. Depletion of central 5-HT neurones after long-term PCA treatment (2 X 10 mg/kg) completely blocked the retention impairment resulting...
Life Sciences
December 6, 1982
J A Clemens, M E Roush
8 citations
The effects of 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), a serotonin agonist with a preferential action on presynaptic autoreceptors, on prolactin release in male rats was determined. Basal serum prolactin levels were not altered after administration of 1.0, 2.0, 5.0, 10.0 or 20.0 mg/kg of 5-MeODMT. Pretreatment with 5-MeODMT reduced prolactin release by agents that depend on serotonergic...