Brain Research
January 2, 2026
B.s. Rabinovitch, N. Silverman, D. Ji et al.
Background and rationaleLysergic acid diethylamide (LSD) is a promising therapeutic for psychiatric disorders, but its physiological profile on the nervous system remains elusive. Rodent electrophysiological data has utilized in vivo single-unit electrophysiology recordings, while clinical neurophysiology studies have focused on spectral signatures using electroencephalography (EEG) and...
Brain Research
June 19, 2025
Zoé Dary, Paul Kobliska, Jacques Léonard et al.
The vestibular system plays a crucial role in body and self perception, as evidenced by the effects of artificial vestibular stimulation in healthy individuals and the depersonalization-like symptoms observed in patients with otoneurological disorders. However, its role in the bodily self-an immediate and pre-reflective form of self-consciousness-remains relatively unexplored. This study...
Brain Research
March 1, 2025
Jannik Nicklas Eliasen, Uffe Kristiansen, Kristi A. Kohlmeier
2 citations
Psychedelics show promise in treating psychiatric disorders. Therapeutic effects appear to involve activation of the 5-Hydroxytryptamine 2A receptor (5-HT2AR), a G protein-coupled receptor (GPCR). Several SNPs of the 5-HT2AR naturally occur, which are associated with differences in receptor function and altered responsiveness to treatments. New compounds suspected to act at the 5-HT2AR are...
Brain Research
January 15, 2025
Lijie Zhou, Xianlei Wang, Tianyu Cao et al.
4 citations
Esketamine is commonly used for sedation or general anaesthesia in infants and young children. However, repeated esketamine administration during periods of rapid brain growth and development may result in various pathophysiological and cognitive changes. Therefore, this study aimed to investigate the influence of recurrent esketamine exposure on long-term behavioural and white matter...
Brain Research
2025
Leonor Miranda
59 citations
Psychedelic drugs that activate the 5HT2A receptor have long been the target of extensive clinical research, particularly in models of psychiatric illness. The aim of this literature review was to investigate the therapeutic effects of 5HT2A receptor activation in the anterior cingulate cortex (ACC) and the respective mechanisms that underlie them. Based on the available research, I suggest...
Brain Research
2025
Ernestas Cizus, Urte Jasinskyte, Robertas Guzulaitis
3 citations
Schizophrenia is believed to be, at least in part, a dysfunction of the glutamatergic system. In line with anatomical evidence, suppressing N-methyl-D-aspartate (NMDA) neurotransmission leads to symptoms that are characteristic of schizophrenia. Rodent models of schizophrenia often involve the acute application of NMDA antagonists, which produce both behavioural and brain activity changes that...
Brain Research
December 1, 2024
Anthony S Zanetti, Kevin S Saroka, Blake T Dotta
The intersection of neuroscience and technology hinges on the development of wearable devices and electrodes that can augment brain networks to improve cognitive capabilities such as learning and concentration. The capacity to enhance networks associated with these functions above baseline capabilities, holds the potential to benefit numerous individuals. The purpose of this study was to...
Brain Research
November 15, 2024
Lijuan Wang, Shuwu Zhao, Jiali Shao et al.
7 citations
Clinical evidence suggests that Esketamine (ESK) is an effective treatment for depression. However, the effects of Esketamine in treating depression-like behavior induced by neuropathic pain is unclear. The underlying molecular mechanisms require further investigation to provide new therapeutic targets for the treatment of clinical neuropathic pain-related depression. A neuropathic pain-related...
Brain Research
2021
Andrea Lavazza
Human cerebral organoids (HCOs) are an in vitro model of early neural development, aimed at modelling and understanding brain development and neurological disorders. In just a few years there has been rapid and considerable progress in the attempt to create a brain model capable of showcasing the characteristics of the human brain. There are still strong limitations to address, including the...
Brain Research
June 13, 2020
Katsuhiro Aikawa, Takayuki Yoshida, Yu Ohmura et al.
Juvenile stress, like that caused by childhood maltreatment, is a significant risk factor for psychiatric disorders such as depression later in life. Recently, the antidepressant effect of ketamine, a noncompetitive N-methyl-d-aspartate receptor antagonist, has been widely investigated. However, little is known regarding its efficacy against depressive-like alterations caused by juvenile...
Brain Research
January 5, 2012
Andrew A Fingelkurts, Alexander A Fingelkurts, Carlos F H Neves
35 citations
Instead of using low-level neurophysiology mimicking and exploratory programming methods commonly used in the machine consciousness field, the hierarchical operational architectonics (OA) framework of brain and mind functioning proposes an alternative conceptual-theoretical framework as a new direction in the area of model-driven machine (robot) consciousness engineering. The unified brain-mind...
Brain Research
June 3, 2011
Gennady G. Knyazev, Jaroslav Y. Slobodskoj-Plusnin, Andrey V. Bocharov et al.
261 citations
The default mode network (DMN) has been principally investigated using positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) and has received mixed support in electroencephalographic (EEG) studies. In particular, the existing evidence is too inconsistent to allow formulation of specific hypotheses linking DMN activity to traditional EEG frequency bands. In this...
Brain Research
April 15, 2011
Jonathan Smallwood, Kevin Brown, Ben Baird et al.
394 citations
The ability to generate and sustain an internal train of thought unrelated to external reality frees an agent from the constraints of only acting on immediate, environmentally triggered events. The current paper proposes that such thought is produced through cooperation between autobiographical information provided by the default mode network and a frontal-parietal control network which helps...
Brain Research
June 1, 2005
Susan Lautar, Camilo Rojas, Barbara S. Slusher et al.
23 citations
Dipeptidyl peptidase IV (DPP IV) is a ubiquitous membrane-bound enzyme that cleaves the two N-terminal amino acids from peptides with a proline or alanine residue in the second position from the amino end. Potential substrates for DPP IV include several neuropeptides, suggesting a role for DPP IV in neurological processes. We have developed a potent DPP IV inhibitor (IC50 = 30 nM),...
Brain Research
March 8, 2005
Alexander Freezer, Abdallah Salem, Rodney J. Irvine
34 citations
3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and para-methoxyamphetamine (PMA) are commonly used recreational drugs. PMA, often mistaken for MDMA, is reported to be more toxic in human use than MDMA. Both of these drugs have been shown to facilitate the release and prevent the reuptake of 5-hydroxytryptamine (5-HT, serotonin). PMA is also a potent inhibitor of monoamine oxidase type A...
Brain Research
August 27, 2004
John W. Muschamp, Meredith J. Regina, Elaine M. Hull et al.
116 citations
The ability of hallucinogens to increase extracellular glutamate in the prefrontal cortex (PFC) was assessed by in vivo microdialysis. The hallucinogen lysergic acid diethylamide (LSD; 0.1 mg/kg, i.p.) caused a time-dependent increase in PFC glutamate that was blocked by the 5-HT(2A) antagonist M100907 (0.05 mg/kg, i.p.). Similarly, the 5-HT(2A/C) agonist [-]-2,5-dimethoxy-4-methylamphetamine...
Brain Research
April 2, 2004
Beth Levant, Thomas L Pazdernik
17 citations
Ibogaine, a hallucinogenic indole alkaloid, has been proposed as a treatment for addiction to opioids and other drugs of abuse. The mechanism for its putative anti-addictive effects is unknown. In this study, the effects of ibogaine on local cerebral glucose utilization (LCGU) were determined in freely moving, drug-naive, or morphine-dependent adult, male, Sprague-Dawley rats using the...
Brain Research
March 25, 2003
Michael T. Williams, Laronda L. Morford, Sandra L. Wood et al.
66 citations
Previously, we have shown that rats administered MDMA from postnatal (P) days 11-20 had reductions in body weight during the period of treatment and as adults they had deficits in sequential and spatial learning and memory. In the present study, to control for weight reductions, we used litters with double the number of offspring to induce growth restriction comparable to that of standard size...
Brain Research
December 1, 2002
Paul S. Frankel, Kathryn A. Cunningham
41 citations
The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat forebrain by a relatively low, behaviorally active, dose of d-LSD (0.16 mg/kg,...
Brain Research
January 12, 2001
S M Turgeon, L C Case
Previous data demonstrate that a single injection of phencyclidine enhances amphetamine-induced behaviors 24 h later, suggesting that the delayed effects of a single dose of phencyclidine may produce a schizophrenia-like state in animals. These behavioral changes were accompanied by altered patterns of c-Fos induction, suggesting possible neurochemical correlates to the observed behaviors....
Brain Research
November 13, 1999
M E Alburges, G R Hanson
11 citations
Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the shrub, Tabernanthe iboga, which has been used to treat stimulant addiction. Because ibogaine influences the activity of neurotensin systems, a dopamine-linked neuropeptide, the present study investigated if ibogaine also influences dynorphin (DYN) pathways. Unlike neurotensin responses, ibogaine alone did not alter DYN levels in...
Brain Research
April 1, 1999
George K. Aghajanian, Gerard J. Marek
379 citations
Previously, serotonin (5-HT) was found to induce a marked increase in glutamatergic spontaneous excitatory postsynaptic currents (EPSCs) in apical dendrites of layer V pyramidal cells of prefrontal cortex; this effect was mediated by 5-HT2A receptors, a proposed site of action of hallucinogenic and atypical antipsychotic drugs. Unexpectedly, although the effect of 5-HT was Ca2+-dependent and...
Brain Research
March 27, 1999
X Yu, Syed Z. Imam, Glenn D. Newport et al.
17 citations
Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, whereas treatment with ibogaine alone produced hypothermia. The ibogaine...
Brain Research
February 6, 1999
M E Alburges, G R Hanson
18 citations
Ibogaine (Endabuse) is a psychoactive indole alkaloid found in the West African shrub, Tabernanthe iboga. This drug interrupts cocaine and amphetamine abuse and has been proposed for treatment of addiction to these stimulants. However, the mechanism of action that explains its pharmacological properties is unclear. Since previous studies demonstrated differential effects of psychotomimetic...
Brain Research
August 3, 1998
D Wei, Isabelle M Maisonneuve, Martin E. Kuehne et al.
48 citations
The iboga alkaloid, ibogaine, its metabolite, noribogaine, and the congener, 18-methoxycoronaridine (18-MC) have all been claimed to have anti-addictive properties in animal models, but the mechanisms underlying these effects are unclear. Ibogaine and noribogaine were shown to have affinity for the serotonin transporter, and inhibition of serotonin reuptake has been proposed to be involved in...