Serotonin: all studies (page 105) - The Consciousness Library

Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").

Pharmacology, Biochemistry, and Behavior December 1988 M D Schechter

A series of three experiments were conducted to investigate the possible serotonergic and dopaminergic mediation of the discriminative stimulus properties of the "designer" drug MDMA. In Experiment 1, rats trained to discriminate 1.5 mg/kg (+/-)-MDMA from its vehicle at 20 min postadministration were shown to generalize to another drug of abuse, N-ethyl-3,4-methylenedioxyamphetamine (MDE) and...

DOI: 10.1016/0091-3057(88)90390-5 Full text

Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine.

Journal of Pharmacology and Experimental Therapeutics October 1, 1988 Donna M. Stone, Michel Johnson, Glen R. Hanson et al.

Similar to other amphetamine analogs 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"), a currently popular illicit drug, has been characterized recently as a serotonergic neurotoxin due to its ability to cause long-lasting deficits in markers of central serotonergic function in animals. Because the serotonergic toxicity associated with the MDMA analog methamphetamine has been linked...

DOI: 10.1016/s0022-3565(25)20051-9

Lysergic acid diethylamide and 2,5-dimethoxy-4-methylamphetamine are partial agonists at serotonin receptors linked to phosphoinositide hydrolysis.

Journal of Pharmacology and Experimental Therapeutics September 1, 1988 Elaine Sanders‐bush, Kevin D. Burris, Karen M. Knoth 155 citations

Based on electrophysiological, radioligand binding, and behavioral studies in laboratory animals, it is generally believed that the psychotomimetic effects of the phenethylamine and indolealkylamine hallucinogens are mediated by central serotonin (5-HT) receptors, in particular the 5-HT-2 subtype. Agonist-stimulated phosphoinositide hydrolysis was utilized to determine the potency and efficacy...

DOI: 10.1016/s0022-3565(25)22189-9 Lysergic acid diethylamide Serotonin Spiperone Pharmacology +7

Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity

Journal of Neuroscience August 1, 1988 Elizabeth O’hearn, Giuseppe Battaglia, Eb de Souza et al. 546 citations

The psychotropic amphetamine derivatives 3,4-methylenedioxyamphetamine (MDA) and 3,4-methylenedioxymethamphetamine (MDMA) have been used for recreational and therapeutic purposes in man. In rats, these drugs cause large reductions in brain levels of serotonin (5-HT). This study employs immunocytochemistry to characterize the neurotoxic effects of these compounds upon monoaminergic neurons in...

DOI: 10.1523/jneurosci.08-08-02788.1988 Full text MDMA Serotonergic Serotonin Axon terminal +8

The effect of benzodiazepines on the 5-HT agonist-induced head-twitch response in mice.

European Journal of Pharmacology July 7, 1988 P C Moser, P H Redfern 21 citations

The effects of four benzodiazepines (diazepam, clonazepam, oxazepam and clobazam) were studied on the head-twitch response induced in mice by several 5-HT receptor agonists. All the benzodiazepines tested potentiated the effects of the directly acting agonists 5-methoxy-N,N-dimethyltryptamine (5-MeODMT), quipazine and mescaline, without themselves inducing head-twitches. In contrast, none of...

DOI: 10.1016/0014-2999(88)90802-3 Full text

Interactions between serotonergic agonists and antagonists in rats trained with LSD as a discriminative stimulus.

Pharmacology, Biochemistry, and Behavior July 1988 Jerrold C Winter, R A Rabin

Drugs purported to have selective affinities for 5-HT1A, 5-HT1B, and 5-HT2 receptors were tested in rats trained with 0.1 mg LSD versus saline. Included were 5-methoxy-dimethyltryptamine (MDMT), 2,5-dimethoxy-4-methyl-amphetamine (DOM), 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), m-trifluoromethylphenyl-piperazine (TFMPP), and 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole...

DOI: 10.1016/0091-3057(88)90074-3 Full text

(±3,4-Methylenedioxymethamphetamine Selectively Damages Central Serotonergic Neurons in Nonhuman Primates

JAMA July 1, 1988 George A. Ricaurte 294 citations

(+/-)3,4-Methylenedioxymethamphetamine (MDMA) is a popular recreational drug that has been proposed to be useful as an adjunct to psychotherapy. This study assessed the neurotoxic potential of MDMA in nonhuman primates. Monkeys were repeatedly administered doses (2.50, 3.75, and 5.00 mg/kg) of MDMA subcutaneously and analyzed for regional brain content of serotonin and 5-hydroxyindoleacetic...

DOI: 10.1001/jama.1988.03410010059035 Serotonergic MDMA Serotonin Neurochemical +6

Synthesis and serotonin receptor affinities of a series of enantiomers of .alpha.-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors

Journal of Medicinal Chemistry July 1, 1988 David Nichols, D. H. Lloyd, Michael P. Johnson et al. 46 citations

A procedure for the preparation of optically pure alpha-methyltryptamines (AMTs) from substituted indoles was developed. The key step in the sequence was the reductive amination of substituted indole-2-propanones with the commercially available pure enantiomers of alpha-methylbenzylamine, followed by the chromatographic separation of the resulting pair of diastereomeric amines by preparative...

DOI: 10.1021/jm00402a026 Serotonin Enantiomer Tryptamines Stereochemistry +5

Vascular postsynaptic effects of some 5-HT1-like receptor agonists in the pithed rat.

European Journal of Pharmacology May 20, 1988 H Dabiré, C Cherqui, B Fournier et al. 10 citations

5-HT induced an increase in blood pressure in the pithed rat which was antagonized by LY 53857 a selective 5-HT2 receptor antagonist. It was not antagonized by spiroxatrine, MDL 72222, idazoxan or AR-C 239, respectively 5-HT1-like and 5-HT3 receptor antagonists, alpha 2- and alpha 1-adrenoceptor antagonists. 5-MeODMT also induced an increase in blood pressure which was antagonized by LY 53857...

DOI: 10.1016/0014-2999(88)90760-1 Full text

Toxic effects of MDMA on central serotonergic neurons in the primate: importance of route and frequency of drug administration.

Brain Research April 12, 1988 George A. Ricaurte, L. Delanney, I. Irwin et al.

This study compared the toxic effects of oral versus subcutaneous and single versus multiple doses of 3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in non-human primates. Orally administered MDMA was approximately one-half as effective as subcutaneously administered drug. Multiple doses were more effective than single doses, but a single 5 mg/kg dose of MDMA given...

DOI: 10.1016/0006-8993(88)91309-1 Full text