A number of studies indicate that glutamatergic N-methyl-D-aspartate (NMDA) neurotransmission is disturbed in schizophrenia partly based on the findings that NMDA receptor antagonists such as phencyclidine (PCP) can reproduce a schizophrenia-like syndrome in both humans and rodents. This study investigated whether repeated administration of low doses of PCP can induce cognitive dysfunctions in...
The effect of phencyclidine (PCP), a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, was examined in the water maze, a spatial learning and memory task dependent on hippocampal functions. Male adult C57Bl/6J mice received daily (s.c.) injections of either saline or PCP (0.25-4.0 mg/kg) for 12 days. During the last 5 days, the injections were followed by water maze training....
The present studies have shown that chronic antidepressant treatment with desipramine (DMI), imipramine (IMI) and zimelidine produced behavioral evidence for sub- and supersensitivity depending on 5-HT agonist dose and types of behavior examined. Thus, chronic treatment with all three drugs reduced head twitches induced by a high dose of the 5-HT agonist 5-methoxy-N,N-dimethyltryptamine...