Lautaro Mundel, Vicente Medel, Christopher Timmermann et al.
Psychedelics are increasingly explored as tools to investigate consciousness and cognition, and as potential treatments for mood disorders. While neuroimaging has been central to characterizing their mechanisms of action, the interpretation of these studies may be confounded by the neurovascular effects elicited by these drugs. Here, we investigated the modulation of resting state neurovascular...
Hilder Mercado-la Peira, José Dussan-Ordoñez, Antistio Alvíz-amador et al.
Study molecular of interaction between N,N-dimethyltryptamine analogs (DMT) with 5-HT1A and 5-HT1B receptors. Likewise, complexes mechanisms that related the interaction with these receptors involved in alterations such as depression, post-traumatic stress disorders and anxiety. Therefore, have been evaluated the activity of DMT analogs by docking molecular studies in the determination of the...
Soukaina Es-Safi, Céline Bourcier-Lucas, Erika Abrial et al.
preprint
ABSTRACT Ketamine at subanaesthetic dose is known as a fast-acting antidepressant (AD), able to facilitate synaptic plasticity in the medial prefrontal cortex (mPFC) or the hippocampus. However, its influence on the serotonergic (5-HT) system is more confusing as it loses its behavioral effects in 5-HT-depleted animals, but does not modify 5-HT neuron function. We hypothesized that this...
Preprints.org
Enzo Tagliazucchi
2 citations
preprint
Serotonergic psychedelics are known to elicit changes in conscious awareness, including perception of the environment and the self, as well as in mood, emotion and different aspects of cognition (Nichols, 2016). The effect of these compounds is complex and resists a straightforward classification that is useful for other drugs, such as “stimulants” or “sedatives”. While the effects of certain...
Behavioural Pharmacology
October 13, 2026
Bart A. Ellenbroek, Beth Naylor, Jiun Youn
Psilocybin has emerged as a promising therapeutic agent, with clinical benefits attributed to enhanced neuroplasticity rather than acute pharmacological effects. However, the fundamental mechanisms underlying these effects remain poorly understood. Using planarians as a model system, we investigated whether psilocybin enhances associative learning using a conditioned place preference paradigm....
Pharmacology, Biochemistry, and Behavior
September 30, 2026
Camila Pasquini De Souza, Vinicius Theiss De Rosso, Daiane Momo Daneluz et al.
Rats emit 50-kHz ultrasonic vocalizations (USVs), a widely used measure of drug-induced motivational and affective effects and dopaminergic activity. Although psychedelic drugs are promising for addiction treatment, the effects of ayahuasca (AYA) on 50-kHz ultrasonic vocalizations (USVs) remain unclear. We investigated whether acute AYA treatment attenuates lisdexamfetamine (LDX)-induced USVs,...
Journal of Neural Transmission
September 19, 2026
Guilherme Lodetti, Henrique Redivo, Amanda Gomes Teixeira et al.
Pharmacotherapy for depression is commonly prescribed, yet fewer than half of patients achieve remission with a single treatment. Many also experience intolerable side effects, highlighting the need for new treatment approaches. Classic psychedelics interact with the serotonin (5-HT) receptor class and are therefore strongly involved in the treatment of psychiatric illnesses such as depression,...
Proceedings of the National Academy of Sciences
September 8, 2026
Andrian G Basargin, Andras Domokosa, Joseph J. Hennessey et al.
Of the classic psychedelics, lysergic acid diethylamide (LSD) is perhaps the best-known, but its complex chemical architecture has limited synthetic investigations aimed at generating analogues with improved safety and efficacy profiles. Here, we systematically deconstruct the tetracyclic ergoline core of LSD to create 9 simplified ergoline analogues (i.e., ergologs) and evaluate them in...
European Journal of Pharmacology
August 18, 2026
Sumin Ban, Kyung Oh Jeon, Su Yeon Seo et al.
3-Fluorophenetrazine (3F-phenetrazine) is a novel amphetamine-like substance that is structurally similar to phenmetrazine and 3F-phenmetrazine. Despite the emergence of 3F-phenetrazine in recreational drug markets, its neuropharmacological profile and abuse liability remain poorly characterized. This study is the first to investigate the psychostimulant, rewarding, and reinforcing properties...
Hearing research
August 1, 2026
Shuhan Lu, Zhixin Zhang, Xinmiao Xue et al.
Subjective tinnitus is a common auditory disorder characterised by the subjective perception of noise in the absence of external sound sources. Its prevalence has been rising annually due to noise exposure, medication misuse, and population ageing. Current tinnitus treatments employ antidepressants, anticonvulsants, and vasodilators, yet most demonstrate limited efficacy with significant side...